The SARS-CoV-2 Spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice

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BACKGROUND: As the pandemic evolves, post-acute sequelae of CoV-2 (PACS) including cardiovascular manifestations have emerged as a new health threat. This study aims to study whether the Spike protein plus obesity can exacerbate PACS-related cardiomyopathy. METHODS: A Spike protein-pseudotyped (Spp)...

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Detalles Bibliográficos
Autores principales: Cao, Xiaoling, Nguyen, Vi, Tsai, Joseph, Gao, Chao, Tian, Yan, Zhang, Yuping, Carver, Wayne, Kiaris, Hippokratis, Cui, Taixing, Tan, Wenbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844011/
https://www.ncbi.nlm.nih.gov/pubmed/36656778
http://dx.doi.org/10.1101/2023.01.05.522853

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