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The SARS-CoV-2 Spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice
BACKGROUND: As the pandemic evolves, post-acute sequelae of CoV-2 (PACS) including cardiovascular manifestations have emerged as a new health threat. This study aims to study whether the Spike protein plus obesity can exacerbate PACS-related cardiomyopathy. METHODS: A Spike protein-pseudotyped (Spp)...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844011/ https://www.ncbi.nlm.nih.gov/pubmed/36656778 http://dx.doi.org/10.1101/2023.01.05.522853 |
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por Cao, Xiaoling, Nguyen, Vi, Tsai, Joseph, Gao, Chao, Tian, Yan, Zhang, Yuping, Carver, Wayne, Kiaris, Hippokratis, Cui, Taixing, Tan, Wenbin
Publicado 2023
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Publicado 2023
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Enlace del recurso
Online
Artículo
Texto