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SARS-CoV-2 Reinfection is Preceded by Unique Biomarkers and Related to Initial Infection Timing and Severity: an N3C RECOVER EHR-Based Cohort Study

Although the COVID-19 pandemic has persisted for over 2 years, reinfections with SARS-CoV-2 are not well understood. We use the electronic health record (EHR)-based study cohort from the National COVID Cohort Collaborative (N3C) as part of the NIH Researching COVID to Enhance Recovery (RECOVER) Init...

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Autores principales: Hadley, Emily, Yoo, Yun Jae, Patel, Saaya, Zhou, Andrea, Laraway, Bryan, Wong, Rachel, Preiss, Alexander, Chew, Rob, Davis, Hannah, Chute, Christopher G, Pfaff, Emily R, Loomba, Johanna, Haendel, Melissa, Hill, Elaine, Moffitt, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844020/
https://www.ncbi.nlm.nih.gov/pubmed/36656776
http://dx.doi.org/10.1101/2023.01.03.22284042
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author Hadley, Emily
Yoo, Yun Jae
Patel, Saaya
Zhou, Andrea
Laraway, Bryan
Wong, Rachel
Preiss, Alexander
Chew, Rob
Davis, Hannah
Chute, Christopher G
Pfaff, Emily R
Loomba, Johanna
Haendel, Melissa
Hill, Elaine
Moffitt, Richard
author_facet Hadley, Emily
Yoo, Yun Jae
Patel, Saaya
Zhou, Andrea
Laraway, Bryan
Wong, Rachel
Preiss, Alexander
Chew, Rob
Davis, Hannah
Chute, Christopher G
Pfaff, Emily R
Loomba, Johanna
Haendel, Melissa
Hill, Elaine
Moffitt, Richard
author_sort Hadley, Emily
collection PubMed
description Although the COVID-19 pandemic has persisted for over 2 years, reinfections with SARS-CoV-2 are not well understood. We use the electronic health record (EHR)-based study cohort from the National COVID Cohort Collaborative (N3C) as part of the NIH Researching COVID to Enhance Recovery (RECOVER) Initiative to characterize reinfection, understand development of Long COVID after reinfection, and compare severity of reinfection with initial infection. We validate previous findings of reinfection incidence (5.9%), the occurrence of most reinfections during the Omicron epoch, and evidence of multiple reinfections. We present novel findings that Long COVID diagnoses occur closer to the index date for infection or reinfection in the Omicron BA epoch. We report lower albumin levels leading up to reinfection and a statistically significant association of severity between first infection and reinfection (chi-squared value: 9446.2, p-value: 0) with a medium effect size (Cramer’s V: 0.18, DoF = 4).
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spelling pubmed-98440202023-01-18 SARS-CoV-2 Reinfection is Preceded by Unique Biomarkers and Related to Initial Infection Timing and Severity: an N3C RECOVER EHR-Based Cohort Study Hadley, Emily Yoo, Yun Jae Patel, Saaya Zhou, Andrea Laraway, Bryan Wong, Rachel Preiss, Alexander Chew, Rob Davis, Hannah Chute, Christopher G Pfaff, Emily R Loomba, Johanna Haendel, Melissa Hill, Elaine Moffitt, Richard medRxiv Article Although the COVID-19 pandemic has persisted for over 2 years, reinfections with SARS-CoV-2 are not well understood. We use the electronic health record (EHR)-based study cohort from the National COVID Cohort Collaborative (N3C) as part of the NIH Researching COVID to Enhance Recovery (RECOVER) Initiative to characterize reinfection, understand development of Long COVID after reinfection, and compare severity of reinfection with initial infection. We validate previous findings of reinfection incidence (5.9%), the occurrence of most reinfections during the Omicron epoch, and evidence of multiple reinfections. We present novel findings that Long COVID diagnoses occur closer to the index date for infection or reinfection in the Omicron BA epoch. We report lower albumin levels leading up to reinfection and a statistically significant association of severity between first infection and reinfection (chi-squared value: 9446.2, p-value: 0) with a medium effect size (Cramer’s V: 0.18, DoF = 4). Cold Spring Harbor Laboratory 2023-01-05 /pmc/articles/PMC9844020/ /pubmed/36656776 http://dx.doi.org/10.1101/2023.01.03.22284042 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Hadley, Emily
Yoo, Yun Jae
Patel, Saaya
Zhou, Andrea
Laraway, Bryan
Wong, Rachel
Preiss, Alexander
Chew, Rob
Davis, Hannah
Chute, Christopher G
Pfaff, Emily R
Loomba, Johanna
Haendel, Melissa
Hill, Elaine
Moffitt, Richard
SARS-CoV-2 Reinfection is Preceded by Unique Biomarkers and Related to Initial Infection Timing and Severity: an N3C RECOVER EHR-Based Cohort Study
title SARS-CoV-2 Reinfection is Preceded by Unique Biomarkers and Related to Initial Infection Timing and Severity: an N3C RECOVER EHR-Based Cohort Study
title_full SARS-CoV-2 Reinfection is Preceded by Unique Biomarkers and Related to Initial Infection Timing and Severity: an N3C RECOVER EHR-Based Cohort Study
title_fullStr SARS-CoV-2 Reinfection is Preceded by Unique Biomarkers and Related to Initial Infection Timing and Severity: an N3C RECOVER EHR-Based Cohort Study
title_full_unstemmed SARS-CoV-2 Reinfection is Preceded by Unique Biomarkers and Related to Initial Infection Timing and Severity: an N3C RECOVER EHR-Based Cohort Study
title_short SARS-CoV-2 Reinfection is Preceded by Unique Biomarkers and Related to Initial Infection Timing and Severity: an N3C RECOVER EHR-Based Cohort Study
title_sort sars-cov-2 reinfection is preceded by unique biomarkers and related to initial infection timing and severity: an n3c recover ehr-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844020/
https://www.ncbi.nlm.nih.gov/pubmed/36656776
http://dx.doi.org/10.1101/2023.01.03.22284042
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