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SARS-CoV-2 Reinfection is Preceded by Unique Biomarkers and Related to Initial Infection Timing and Severity: an N3C RECOVER EHR-Based Cohort Study
Although the COVID-19 pandemic has persisted for over 2 years, reinfections with SARS-CoV-2 are not well understood. We use the electronic health record (EHR)-based study cohort from the National COVID Cohort Collaborative (N3C) as part of the NIH Researching COVID to Enhance Recovery (RECOVER) Init...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844020/ https://www.ncbi.nlm.nih.gov/pubmed/36656776 http://dx.doi.org/10.1101/2023.01.03.22284042 |
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author | Hadley, Emily Yoo, Yun Jae Patel, Saaya Zhou, Andrea Laraway, Bryan Wong, Rachel Preiss, Alexander Chew, Rob Davis, Hannah Chute, Christopher G Pfaff, Emily R Loomba, Johanna Haendel, Melissa Hill, Elaine Moffitt, Richard |
author_facet | Hadley, Emily Yoo, Yun Jae Patel, Saaya Zhou, Andrea Laraway, Bryan Wong, Rachel Preiss, Alexander Chew, Rob Davis, Hannah Chute, Christopher G Pfaff, Emily R Loomba, Johanna Haendel, Melissa Hill, Elaine Moffitt, Richard |
author_sort | Hadley, Emily |
collection | PubMed |
description | Although the COVID-19 pandemic has persisted for over 2 years, reinfections with SARS-CoV-2 are not well understood. We use the electronic health record (EHR)-based study cohort from the National COVID Cohort Collaborative (N3C) as part of the NIH Researching COVID to Enhance Recovery (RECOVER) Initiative to characterize reinfection, understand development of Long COVID after reinfection, and compare severity of reinfection with initial infection. We validate previous findings of reinfection incidence (5.9%), the occurrence of most reinfections during the Omicron epoch, and evidence of multiple reinfections. We present novel findings that Long COVID diagnoses occur closer to the index date for infection or reinfection in the Omicron BA epoch. We report lower albumin levels leading up to reinfection and a statistically significant association of severity between first infection and reinfection (chi-squared value: 9446.2, p-value: 0) with a medium effect size (Cramer’s V: 0.18, DoF = 4). |
format | Online Article Text |
id | pubmed-9844020 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-98440202023-01-18 SARS-CoV-2 Reinfection is Preceded by Unique Biomarkers and Related to Initial Infection Timing and Severity: an N3C RECOVER EHR-Based Cohort Study Hadley, Emily Yoo, Yun Jae Patel, Saaya Zhou, Andrea Laraway, Bryan Wong, Rachel Preiss, Alexander Chew, Rob Davis, Hannah Chute, Christopher G Pfaff, Emily R Loomba, Johanna Haendel, Melissa Hill, Elaine Moffitt, Richard medRxiv Article Although the COVID-19 pandemic has persisted for over 2 years, reinfections with SARS-CoV-2 are not well understood. We use the electronic health record (EHR)-based study cohort from the National COVID Cohort Collaborative (N3C) as part of the NIH Researching COVID to Enhance Recovery (RECOVER) Initiative to characterize reinfection, understand development of Long COVID after reinfection, and compare severity of reinfection with initial infection. We validate previous findings of reinfection incidence (5.9%), the occurrence of most reinfections during the Omicron epoch, and evidence of multiple reinfections. We present novel findings that Long COVID diagnoses occur closer to the index date for infection or reinfection in the Omicron BA epoch. We report lower albumin levels leading up to reinfection and a statistically significant association of severity between first infection and reinfection (chi-squared value: 9446.2, p-value: 0) with a medium effect size (Cramer’s V: 0.18, DoF = 4). Cold Spring Harbor Laboratory 2023-01-05 /pmc/articles/PMC9844020/ /pubmed/36656776 http://dx.doi.org/10.1101/2023.01.03.22284042 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. |
spellingShingle | Article Hadley, Emily Yoo, Yun Jae Patel, Saaya Zhou, Andrea Laraway, Bryan Wong, Rachel Preiss, Alexander Chew, Rob Davis, Hannah Chute, Christopher G Pfaff, Emily R Loomba, Johanna Haendel, Melissa Hill, Elaine Moffitt, Richard SARS-CoV-2 Reinfection is Preceded by Unique Biomarkers and Related to Initial Infection Timing and Severity: an N3C RECOVER EHR-Based Cohort Study |
title | SARS-CoV-2 Reinfection is Preceded by Unique Biomarkers and Related to Initial Infection Timing and Severity: an N3C RECOVER EHR-Based Cohort Study |
title_full | SARS-CoV-2 Reinfection is Preceded by Unique Biomarkers and Related to Initial Infection Timing and Severity: an N3C RECOVER EHR-Based Cohort Study |
title_fullStr | SARS-CoV-2 Reinfection is Preceded by Unique Biomarkers and Related to Initial Infection Timing and Severity: an N3C RECOVER EHR-Based Cohort Study |
title_full_unstemmed | SARS-CoV-2 Reinfection is Preceded by Unique Biomarkers and Related to Initial Infection Timing and Severity: an N3C RECOVER EHR-Based Cohort Study |
title_short | SARS-CoV-2 Reinfection is Preceded by Unique Biomarkers and Related to Initial Infection Timing and Severity: an N3C RECOVER EHR-Based Cohort Study |
title_sort | sars-cov-2 reinfection is preceded by unique biomarkers and related to initial infection timing and severity: an n3c recover ehr-based cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844020/ https://www.ncbi.nlm.nih.gov/pubmed/36656776 http://dx.doi.org/10.1101/2023.01.03.22284042 |
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