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Bulky Adducts in Clustered DNA Lesions: Causes of Resistance to the NER System
The nucleotide excision repair (NER) system removes a wide range of bulky DNA lesions that cause significant distortions of the regular double helix structure. These lesions, mainly bulky covalent DNA adducts, are induced by ultraviolet and ionizing radiation or the interaction between exogenous/end...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
A.I. Gordeyev
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844087/ https://www.ncbi.nlm.nih.gov/pubmed/36694906 http://dx.doi.org/10.32607/actanaturae.11741 |
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author | Naumenko, N. V. Petruseva, I. O. Lavrik, O. I. |
author_facet | Naumenko, N. V. Petruseva, I. O. Lavrik, O. I. |
author_sort | Naumenko, N. V. |
collection | PubMed |
description | The nucleotide excision repair (NER) system removes a wide range of bulky DNA lesions that cause significant distortions of the regular double helix structure. These lesions, mainly bulky covalent DNA adducts, are induced by ultraviolet and ionizing radiation or the interaction between exogenous/endogenous chemically active substances and nitrogenous DNA bases. As the number of DNA lesions increases, e.g., due to intensive chemotherapy and combination therapy of various diseases or DNA repair impairment, clustered lesions containing bulky adducts may occur. Clustered lesions are two or more lesions located within one or two turns of the DNA helix. Despite the fact that repair of single DNA lesions by the NER system in eukaryotic cells has been studied quite thoroughly, the repair mechanism of these lesions in clusters remains obscure. Identification of the structural features of the DNA regions containing irreparable clustered lesions is of considerable interest, in particular due to a relationship between the efficiency of some antitumor drugs and the activity of cellular repair systems. In this review, we analyzed data on the induction of clustered lesions containing bulky adducts, the potential biological significance of these lesions, and methods for quantification of DNA lesions and considered the causes for the inhibition of NER-catalyzed excision of clustered bulky lesions. |
format | Online Article Text |
id | pubmed-9844087 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | A.I. Gordeyev |
record_format | MEDLINE/PubMed |
spelling | pubmed-98440872023-01-23 Bulky Adducts in Clustered DNA Lesions: Causes of Resistance to the NER System Naumenko, N. V. Petruseva, I. O. Lavrik, O. I. Acta Naturae Research Article The nucleotide excision repair (NER) system removes a wide range of bulky DNA lesions that cause significant distortions of the regular double helix structure. These lesions, mainly bulky covalent DNA adducts, are induced by ultraviolet and ionizing radiation or the interaction between exogenous/endogenous chemically active substances and nitrogenous DNA bases. As the number of DNA lesions increases, e.g., due to intensive chemotherapy and combination therapy of various diseases or DNA repair impairment, clustered lesions containing bulky adducts may occur. Clustered lesions are two or more lesions located within one or two turns of the DNA helix. Despite the fact that repair of single DNA lesions by the NER system in eukaryotic cells has been studied quite thoroughly, the repair mechanism of these lesions in clusters remains obscure. Identification of the structural features of the DNA regions containing irreparable clustered lesions is of considerable interest, in particular due to a relationship between the efficiency of some antitumor drugs and the activity of cellular repair systems. In this review, we analyzed data on the induction of clustered lesions containing bulky adducts, the potential biological significance of these lesions, and methods for quantification of DNA lesions and considered the causes for the inhibition of NER-catalyzed excision of clustered bulky lesions. A.I. Gordeyev 2022 /pmc/articles/PMC9844087/ /pubmed/36694906 http://dx.doi.org/10.32607/actanaturae.11741 Text en Copyright ® 2022 National Research University Higher School of Economics. https://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Naumenko, N. V. Petruseva, I. O. Lavrik, O. I. Bulky Adducts in Clustered DNA Lesions: Causes of Resistance to the NER System |
title | Bulky Adducts in Clustered DNA Lesions: Causes of Resistance to the NER System |
title_full | Bulky Adducts in Clustered DNA Lesions: Causes of Resistance to the NER System |
title_fullStr | Bulky Adducts in Clustered DNA Lesions: Causes of Resistance to the NER System |
title_full_unstemmed | Bulky Adducts in Clustered DNA Lesions: Causes of Resistance to the NER System |
title_short | Bulky Adducts in Clustered DNA Lesions: Causes of Resistance to the NER System |
title_sort | bulky adducts in clustered dna lesions: causes of resistance to the ner system |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844087/ https://www.ncbi.nlm.nih.gov/pubmed/36694906 http://dx.doi.org/10.32607/actanaturae.11741 |
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