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Rhodobacter capsulatus PG Lipopolysaccharide Blocks the Effects of a Lipoteichoic Acid, a Toll-Like Receptor 2 Agonist

Lipopolysaccharides (LPS) and lipoteichoic acids (LTA) are the major inducers of the inflammatory response of blood cells caused by Gram-negative and some Gram-positive bacteria. CD14 is a common receptor for LPS and LTA that transfers the ligands to TLR4 and TLR2, respectively. In this work, we hav...

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Autores principales: Zubova, S. V., Kosyakova, N. I., Grachev, S. V., Prokhorenko, I. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844088/
https://www.ncbi.nlm.nih.gov/pubmed/36694898
http://dx.doi.org/10.32607/actanaturae.11747
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author Zubova, S. V.
Kosyakova, N. I.
Grachev, S. V.
Prokhorenko, I. R.
author_facet Zubova, S. V.
Kosyakova, N. I.
Grachev, S. V.
Prokhorenko, I. R.
author_sort Zubova, S. V.
collection PubMed
description Lipopolysaccharides (LPS) and lipoteichoic acids (LTA) are the major inducers of the inflammatory response of blood cells caused by Gram-negative and some Gram-positive bacteria. CD14 is a common receptor for LPS and LTA that transfers the ligands to TLR4 and TLR2, respectively. In this work, we have demonstrated that the non-toxic LPS from Rhodobacter capsulatus PG blocks the synthesis of pro-inflammatory cytokines during the activation of blood cells by Streptococcus pyogenes LTA through binding to the CD14 receptor, resulting in the signal transduction to TLR2/TLR6 being blocked. The LPS from Rhodobacter capsulatus PG can be considered a prototype for developing preparations to protect blood cells against the LTA of gram-positive bacteria.
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spelling pubmed-98440882023-01-23 Rhodobacter capsulatus PG Lipopolysaccharide Blocks the Effects of a Lipoteichoic Acid, a Toll-Like Receptor 2 Agonist Zubova, S. V. Kosyakova, N. I. Grachev, S. V. Prokhorenko, I. R. Acta Naturae Research Article Lipopolysaccharides (LPS) and lipoteichoic acids (LTA) are the major inducers of the inflammatory response of blood cells caused by Gram-negative and some Gram-positive bacteria. CD14 is a common receptor for LPS and LTA that transfers the ligands to TLR4 and TLR2, respectively. In this work, we have demonstrated that the non-toxic LPS from Rhodobacter capsulatus PG blocks the synthesis of pro-inflammatory cytokines during the activation of blood cells by Streptococcus pyogenes LTA through binding to the CD14 receptor, resulting in the signal transduction to TLR2/TLR6 being blocked. The LPS from Rhodobacter capsulatus PG can be considered a prototype for developing preparations to protect blood cells against the LTA of gram-positive bacteria. A.I. Gordeyev 2022 /pmc/articles/PMC9844088/ /pubmed/36694898 http://dx.doi.org/10.32607/actanaturae.11747 Text en Copyright ® 2022 National Research University Higher School of Economics. https://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zubova, S. V.
Kosyakova, N. I.
Grachev, S. V.
Prokhorenko, I. R.
Rhodobacter capsulatus PG Lipopolysaccharide Blocks the Effects of a Lipoteichoic Acid, a Toll-Like Receptor 2 Agonist
title Rhodobacter capsulatus PG Lipopolysaccharide Blocks the Effects of a Lipoteichoic Acid, a Toll-Like Receptor 2 Agonist
title_full Rhodobacter capsulatus PG Lipopolysaccharide Blocks the Effects of a Lipoteichoic Acid, a Toll-Like Receptor 2 Agonist
title_fullStr Rhodobacter capsulatus PG Lipopolysaccharide Blocks the Effects of a Lipoteichoic Acid, a Toll-Like Receptor 2 Agonist
title_full_unstemmed Rhodobacter capsulatus PG Lipopolysaccharide Blocks the Effects of a Lipoteichoic Acid, a Toll-Like Receptor 2 Agonist
title_short Rhodobacter capsulatus PG Lipopolysaccharide Blocks the Effects of a Lipoteichoic Acid, a Toll-Like Receptor 2 Agonist
title_sort rhodobacter capsulatus pg lipopolysaccharide blocks the effects of a lipoteichoic acid, a toll-like receptor 2 agonist
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844088/
https://www.ncbi.nlm.nih.gov/pubmed/36694898
http://dx.doi.org/10.32607/actanaturae.11747
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