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Serum Magnesium is Inversely Associated with Body Composition and Metabolic Syndrome

PURPOSE: Magnesium is vital to maintain normal physiological functions. We aimed to identify the association between serum magnesium and different measures of body adiposity among Qatari adults. We hypothesized that the association was mediated by depression and sleep duration. PATIENTS AND METHODS:...

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Autores principales: Al Shammaa, AlMaha, Al-Thani, Amna, Al-Kaabi, Maryam, Al-Saeed, Kaltham, Alanazi, Maria, Shi, Zumin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844104/
https://www.ncbi.nlm.nih.gov/pubmed/36760601
http://dx.doi.org/10.2147/DMSO.S391369
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author Al Shammaa, AlMaha
Al-Thani, Amna
Al-Kaabi, Maryam
Al-Saeed, Kaltham
Alanazi, Maria
Shi, Zumin
author_facet Al Shammaa, AlMaha
Al-Thani, Amna
Al-Kaabi, Maryam
Al-Saeed, Kaltham
Alanazi, Maria
Shi, Zumin
author_sort Al Shammaa, AlMaha
collection PubMed
description PURPOSE: Magnesium is vital to maintain normal physiological functions. We aimed to identify the association between serum magnesium and different measures of body adiposity among Qatari adults. We hypothesized that the association was mediated by depression and sleep duration. PATIENTS AND METHODS: The study included 1000 adults aged 20 years and above who attended the Qatar Biobank Study (QBB) between 2012 and 2019. Body adiposity was assessed using dual-energy X-ray absorptiometry (DEXA). Serum magnesium concentration was measured. Sub-optimal magnesium was defined as magnesium concentration less than 0.85 mmol/L. The association was examined using linear regression. RESULTS: The mean age of the participants (n=1000) was 35.8 (SD 10.3) years. More than half of the participants had sub-optimal magnesium concentrations (60.2% in men and 52.3% in women). Serum magnesium was inversely associated with different types of fat mass. In the fully adjusted model, per 1 SD increment of serum magnesium had standardized regression coefficients of −0.09 (p 0.005) for total fat mass, −0.08 (p 0.008) for trunk fat, −0.09 (p 0.003) for gynoid fat and −0.08 (p 0.008) for android fat. There was no gender difference in the association. The inverse association between serum magnesium and fat mass was significant in those with sleep duration ≥7 hours but not in those <7 hours. Depressive symptom and sleep did not mediate the association between serum magnesium and fat mass. Serum magnesium was inversely associated with metabolic syndrome (per 1 SD increment had an odds ratio (OR) of 0.70 (95% CI 0.57–0.85)). CONCLUSION: There was an inverse association between serum magnesium and fat mass, especially among those with an adequate sleep duration and without chronic conditions including diabetes, hypertension and depression.
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spelling pubmed-98441042023-02-08 Serum Magnesium is Inversely Associated with Body Composition and Metabolic Syndrome Al Shammaa, AlMaha Al-Thani, Amna Al-Kaabi, Maryam Al-Saeed, Kaltham Alanazi, Maria Shi, Zumin Diabetes Metab Syndr Obes Original Research PURPOSE: Magnesium is vital to maintain normal physiological functions. We aimed to identify the association between serum magnesium and different measures of body adiposity among Qatari adults. We hypothesized that the association was mediated by depression and sleep duration. PATIENTS AND METHODS: The study included 1000 adults aged 20 years and above who attended the Qatar Biobank Study (QBB) between 2012 and 2019. Body adiposity was assessed using dual-energy X-ray absorptiometry (DEXA). Serum magnesium concentration was measured. Sub-optimal magnesium was defined as magnesium concentration less than 0.85 mmol/L. The association was examined using linear regression. RESULTS: The mean age of the participants (n=1000) was 35.8 (SD 10.3) years. More than half of the participants had sub-optimal magnesium concentrations (60.2% in men and 52.3% in women). Serum magnesium was inversely associated with different types of fat mass. In the fully adjusted model, per 1 SD increment of serum magnesium had standardized regression coefficients of −0.09 (p 0.005) for total fat mass, −0.08 (p 0.008) for trunk fat, −0.09 (p 0.003) for gynoid fat and −0.08 (p 0.008) for android fat. There was no gender difference in the association. The inverse association between serum magnesium and fat mass was significant in those with sleep duration ≥7 hours but not in those <7 hours. Depressive symptom and sleep did not mediate the association between serum magnesium and fat mass. Serum magnesium was inversely associated with metabolic syndrome (per 1 SD increment had an odds ratio (OR) of 0.70 (95% CI 0.57–0.85)). CONCLUSION: There was an inverse association between serum magnesium and fat mass, especially among those with an adequate sleep duration and without chronic conditions including diabetes, hypertension and depression. Dove 2023-01-12 /pmc/articles/PMC9844104/ /pubmed/36760601 http://dx.doi.org/10.2147/DMSO.S391369 Text en © 2023 Al Shammaa et al. https://creativecommons.org/licenses/by/4.0/This work is published by Dove Medical Press Limited, and licensed under a Creative Commons Attribution License. The full terms of the License are available at http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Research
Al Shammaa, AlMaha
Al-Thani, Amna
Al-Kaabi, Maryam
Al-Saeed, Kaltham
Alanazi, Maria
Shi, Zumin
Serum Magnesium is Inversely Associated with Body Composition and Metabolic Syndrome
title Serum Magnesium is Inversely Associated with Body Composition and Metabolic Syndrome
title_full Serum Magnesium is Inversely Associated with Body Composition and Metabolic Syndrome
title_fullStr Serum Magnesium is Inversely Associated with Body Composition and Metabolic Syndrome
title_full_unstemmed Serum Magnesium is Inversely Associated with Body Composition and Metabolic Syndrome
title_short Serum Magnesium is Inversely Associated with Body Composition and Metabolic Syndrome
title_sort serum magnesium is inversely associated with body composition and metabolic syndrome
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844104/
https://www.ncbi.nlm.nih.gov/pubmed/36760601
http://dx.doi.org/10.2147/DMSO.S391369
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