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Sequential delay and probability discounting tasks in mice reveal anchoring effects partially attributable to decision noise

Delay discounting and probability discounting decision making tasks in rodent models have high translational potential. However, it is unclear whether the discounted value of the large reward option is the main contributor to variability in animals’ choices in either task, which may limit translatio...

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Autores principales: Rojas, Gerardo R., Curry-Pochy, Lisa S., Chen, Cathy S., Heller, Abigail T., Grissom, Nicola M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844124/
https://www.ncbi.nlm.nih.gov/pubmed/35661751
http://dx.doi.org/10.1016/j.bbr.2022.113951
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author Rojas, Gerardo R.
Curry-Pochy, Lisa S.
Chen, Cathy S.
Heller, Abigail T.
Grissom, Nicola M.
author_facet Rojas, Gerardo R.
Curry-Pochy, Lisa S.
Chen, Cathy S.
Heller, Abigail T.
Grissom, Nicola M.
author_sort Rojas, Gerardo R.
collection PubMed
description Delay discounting and probability discounting decision making tasks in rodent models have high translational potential. However, it is unclear whether the discounted value of the large reward option is the main contributor to variability in animals’ choices in either task, which may limit translation to humans. Male and female mice underwent sessions of delay and probability discounting in sequence to assess how choice behavior adapts over experience with each task. To control for “anchoring” (persistent choices based on the initial delay or probability), mice experienced “Worsening” schedules where the large reward was offered under initially favorable conditions that became less favorable during testing, followed by “Improving” schedules where the large reward was offered under initially unfavorable conditions that improved over a session. During delay discounting, both male and female mice showed elimination of anchoring effects over training. In probability discounting, both sexes of mice continued to show some anchoring even after months of training. One possibility is that “noisy”, exploratory choices could contribute to these persistent anchoring effects, rather than constant fluctuations in value discounting. We fit choice behavior in individual animals using models that included both a value-based discounting parameter and a decision noise parameter that captured variability in choices deviating from value maximization. Changes in anchoring behavior over time were tracked by changes in both the value and decision noise parameters in delay discounting, but by the decision noise parameter in probability discounting. Exploratory decision making was also reflected in choice response times that tracked the degree of conflict caused by both uncertainty and temporal cost, but was not linked with differences in locomotor activity reflecting chamber exploration. Thus, variable discounting behavior in mice can result from changes in exploration of the decision options rather than changes in reward valuation.
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spelling pubmed-98441242023-01-17 Sequential delay and probability discounting tasks in mice reveal anchoring effects partially attributable to decision noise Rojas, Gerardo R. Curry-Pochy, Lisa S. Chen, Cathy S. Heller, Abigail T. Grissom, Nicola M. Behav Brain Res Article Delay discounting and probability discounting decision making tasks in rodent models have high translational potential. However, it is unclear whether the discounted value of the large reward option is the main contributor to variability in animals’ choices in either task, which may limit translation to humans. Male and female mice underwent sessions of delay and probability discounting in sequence to assess how choice behavior adapts over experience with each task. To control for “anchoring” (persistent choices based on the initial delay or probability), mice experienced “Worsening” schedules where the large reward was offered under initially favorable conditions that became less favorable during testing, followed by “Improving” schedules where the large reward was offered under initially unfavorable conditions that improved over a session. During delay discounting, both male and female mice showed elimination of anchoring effects over training. In probability discounting, both sexes of mice continued to show some anchoring even after months of training. One possibility is that “noisy”, exploratory choices could contribute to these persistent anchoring effects, rather than constant fluctuations in value discounting. We fit choice behavior in individual animals using models that included both a value-based discounting parameter and a decision noise parameter that captured variability in choices deviating from value maximization. Changes in anchoring behavior over time were tracked by changes in both the value and decision noise parameters in delay discounting, but by the decision noise parameter in probability discounting. Exploratory decision making was also reflected in choice response times that tracked the degree of conflict caused by both uncertainty and temporal cost, but was not linked with differences in locomotor activity reflecting chamber exploration. Thus, variable discounting behavior in mice can result from changes in exploration of the decision options rather than changes in reward valuation. 2022-08-05 2022-06-02 /pmc/articles/PMC9844124/ /pubmed/35661751 http://dx.doi.org/10.1016/j.bbr.2022.113951 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Rojas, Gerardo R.
Curry-Pochy, Lisa S.
Chen, Cathy S.
Heller, Abigail T.
Grissom, Nicola M.
Sequential delay and probability discounting tasks in mice reveal anchoring effects partially attributable to decision noise
title Sequential delay and probability discounting tasks in mice reveal anchoring effects partially attributable to decision noise
title_full Sequential delay and probability discounting tasks in mice reveal anchoring effects partially attributable to decision noise
title_fullStr Sequential delay and probability discounting tasks in mice reveal anchoring effects partially attributable to decision noise
title_full_unstemmed Sequential delay and probability discounting tasks in mice reveal anchoring effects partially attributable to decision noise
title_short Sequential delay and probability discounting tasks in mice reveal anchoring effects partially attributable to decision noise
title_sort sequential delay and probability discounting tasks in mice reveal anchoring effects partially attributable to decision noise
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844124/
https://www.ncbi.nlm.nih.gov/pubmed/35661751
http://dx.doi.org/10.1016/j.bbr.2022.113951
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