Surface Engineering of HEK293 Cell-Derived Extracellular Vesicles for Improved Pharmacokinetic Profile and Targeted Delivery of IL-12 for the Treatment of Hepatocellular Carcinoma

BACKGROUND: Extracellular vesicles (EVs) are considered a promising drug delivery platform. Naïve EVs face numerous issues that limit their applications, such as fast clearance, hepatic accumulations, and a lack of target-specific tropism. We aimed to explore a series of surface engineering approach...

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Detalles Bibliográficos
Autores principales: Zhang, Jing, Song, Haijing, Dong, Yanan, Li, Ganghui, Li, Jun, Cai, Qizhe, Yuan, Shoujun, Wang, Yi, Song, Haifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844138/
https://www.ncbi.nlm.nih.gov/pubmed/36660339
http://dx.doi.org/10.2147/IJN.S388916

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