Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking

While lung cancer risk among smokers is dependent on smoking dose, it remains unknown if this increased risk reflects an increased rate of somatic mutation accumulation in normal lung cells. Here we applied single-cell whole genome sequencing of proximal bronchial basal cells from 33 subjects aged b...

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Detalles Bibliográficos
Autores principales: Huang, Zhenqiu, Sun, Shixiang, Lee, Moonsook, Maslov, Alexander Y., Shi, Miao, Waldman, Spencer, Marsh, Ava, Siddiqui, Taha, Dong, Xiao, Peter, Yakov, Sadoughi, Ali, Shah, Chirag, Ye, Kenny, Spivack, Simon D, Vijg, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844147/
https://www.ncbi.nlm.nih.gov/pubmed/35410377
http://dx.doi.org/10.1038/s41588-022-01035-w

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