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Determinants of 1-Year Adverse Event Requiring Re-Hospitalization in COVID-19 Oldest Old Survivors

The incidence of “Long COVID” syndrome appears to be increasing, particularly in the geriatric population. At present, there are few data regarding the relationship between long COVID and the risk of re-hospitalization in the oldest old survivors. Patients older than 80 years consecutively hospitali...

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Autores principales: Okoye, Chukwuma, Franchi, Riccardo, Calabrese, Alessia Maria, Morelli, Virginia, Peta, Umberto, Mazzarone, Tessa, Pompilii, Igino Maria, Coppini, Giulia, Rogani, Sara, Calsolaro, Valeria, Monzani, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844439/
https://www.ncbi.nlm.nih.gov/pubmed/36648915
http://dx.doi.org/10.3390/geriatrics8010010
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author Okoye, Chukwuma
Franchi, Riccardo
Calabrese, Alessia Maria
Morelli, Virginia
Peta, Umberto
Mazzarone, Tessa
Pompilii, Igino Maria
Coppini, Giulia
Rogani, Sara
Calsolaro, Valeria
Monzani, Fabio
author_facet Okoye, Chukwuma
Franchi, Riccardo
Calabrese, Alessia Maria
Morelli, Virginia
Peta, Umberto
Mazzarone, Tessa
Pompilii, Igino Maria
Coppini, Giulia
Rogani, Sara
Calsolaro, Valeria
Monzani, Fabio
author_sort Okoye, Chukwuma
collection PubMed
description The incidence of “Long COVID” syndrome appears to be increasing, particularly in the geriatric population. At present, there are few data regarding the relationship between long COVID and the risk of re-hospitalization in the oldest old survivors. Patients older than 80 years consecutively hospitalized for COVID-19 in our tertiary care hospital were enrolled and followed after discharge in a 12-month ambulatory program. A comprehensive geriatric assessment (CGA), including functional capabilities and physical and cognitive performances, was performed at 6-month follow-up. Frailty degree was assessed using a 30-item frailty index. The re-hospitalization rate was assessed at 12-month follow-up through a computerized archive and phone interviews. Out of 100 patients discharged after hospitalization for COVID-19 (mean [SD] age 85 [4.0] years), 24 reported serious adverse events requiring re-hospitalization within 12 months. The most frequent causes of re-hospitalization were acute heart failure (HF), pneumonia and bone fracture (15.3% each). By multivariate logistic analysis, after adjustment for potential confounders, history of chronic HF [aOR: 3.00 (CI 95%: 1.10–8.16), p = 0.031] or chronic renal failure [aOR: 3.83 (CI 95%: 1.09–13.43), p = 0.036], the burden of comorbidity [(CIRSc) aOR: 1.95 (CI 95%: 1.28–2.97), p = 0.002] and frailty [aOR: 7.77 (CI 95%: 2.13–28.27), p = 0.002] resulted as independent predictors of re-hospitalization. One-fourth of the oldest old patients previously hospitalized for COVID-19 suffered from adverse events requiring re-hospitalization, two-thirds of them within three months after discharge. Frailty, the burden of comorbidity, history of chronic HF or chronic renal failure, but not COVID-19 disease severity, independently predicted re-hospitalization.
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spelling pubmed-98444392023-01-18 Determinants of 1-Year Adverse Event Requiring Re-Hospitalization in COVID-19 Oldest Old Survivors Okoye, Chukwuma Franchi, Riccardo Calabrese, Alessia Maria Morelli, Virginia Peta, Umberto Mazzarone, Tessa Pompilii, Igino Maria Coppini, Giulia Rogani, Sara Calsolaro, Valeria Monzani, Fabio Geriatrics (Basel) Article The incidence of “Long COVID” syndrome appears to be increasing, particularly in the geriatric population. At present, there are few data regarding the relationship between long COVID and the risk of re-hospitalization in the oldest old survivors. Patients older than 80 years consecutively hospitalized for COVID-19 in our tertiary care hospital were enrolled and followed after discharge in a 12-month ambulatory program. A comprehensive geriatric assessment (CGA), including functional capabilities and physical and cognitive performances, was performed at 6-month follow-up. Frailty degree was assessed using a 30-item frailty index. The re-hospitalization rate was assessed at 12-month follow-up through a computerized archive and phone interviews. Out of 100 patients discharged after hospitalization for COVID-19 (mean [SD] age 85 [4.0] years), 24 reported serious adverse events requiring re-hospitalization within 12 months. The most frequent causes of re-hospitalization were acute heart failure (HF), pneumonia and bone fracture (15.3% each). By multivariate logistic analysis, after adjustment for potential confounders, history of chronic HF [aOR: 3.00 (CI 95%: 1.10–8.16), p = 0.031] or chronic renal failure [aOR: 3.83 (CI 95%: 1.09–13.43), p = 0.036], the burden of comorbidity [(CIRSc) aOR: 1.95 (CI 95%: 1.28–2.97), p = 0.002] and frailty [aOR: 7.77 (CI 95%: 2.13–28.27), p = 0.002] resulted as independent predictors of re-hospitalization. One-fourth of the oldest old patients previously hospitalized for COVID-19 suffered from adverse events requiring re-hospitalization, two-thirds of them within three months after discharge. Frailty, the burden of comorbidity, history of chronic HF or chronic renal failure, but not COVID-19 disease severity, independently predicted re-hospitalization. MDPI 2023-01-10 /pmc/articles/PMC9844439/ /pubmed/36648915 http://dx.doi.org/10.3390/geriatrics8010010 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Okoye, Chukwuma
Franchi, Riccardo
Calabrese, Alessia Maria
Morelli, Virginia
Peta, Umberto
Mazzarone, Tessa
Pompilii, Igino Maria
Coppini, Giulia
Rogani, Sara
Calsolaro, Valeria
Monzani, Fabio
Determinants of 1-Year Adverse Event Requiring Re-Hospitalization in COVID-19 Oldest Old Survivors
title Determinants of 1-Year Adverse Event Requiring Re-Hospitalization in COVID-19 Oldest Old Survivors
title_full Determinants of 1-Year Adverse Event Requiring Re-Hospitalization in COVID-19 Oldest Old Survivors
title_fullStr Determinants of 1-Year Adverse Event Requiring Re-Hospitalization in COVID-19 Oldest Old Survivors
title_full_unstemmed Determinants of 1-Year Adverse Event Requiring Re-Hospitalization in COVID-19 Oldest Old Survivors
title_short Determinants of 1-Year Adverse Event Requiring Re-Hospitalization in COVID-19 Oldest Old Survivors
title_sort determinants of 1-year adverse event requiring re-hospitalization in covid-19 oldest old survivors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844439/
https://www.ncbi.nlm.nih.gov/pubmed/36648915
http://dx.doi.org/10.3390/geriatrics8010010
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