High-Level Production of Soluble Cross-Reacting Material 197 in Escherichia coli Cytoplasm Due to Fine Tuning of the Target Gene’s mRNA Structure

Cross-reacting material 197 (CRM197) is a non-toxic mutant of the diphtheria toxin and is widely used as a carrier protein in conjugate vaccines. This protein was first obtained from the supernatant of the mutant Corynebacterium diphtheriae strain. This pathogenic bacteria strain is characterized by...

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Detalles Bibliográficos
Autores principales: Khodak, Yulia Alexandrovna, Ryazanova, Alexandra Yurievna, Vorobiev, Ivan Ivanovich, Kovalchuk, Alexander Leonidovich, Ovechko, Nikolay Nikolaevich, Aparin, Petr Gennadievich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844443/
https://www.ncbi.nlm.nih.gov/pubmed/36648835
http://dx.doi.org/10.3390/biotech12010009

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