Impact of concomitant fibrates on immunotherapy outcomes for advanced non‐small cell lung cancer

BACKGROUND: Peroxisome proliferator‐activated receptor agonists such as fibrates restore oxidative metabolism in cytotoxic T‐lymphocytes, thereby enhancing response to immune checkpoint inhibitors (ICI) in preclinical models. However, there is no evidence in humans on the clinical impact of fibrates...

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Detalles Bibliográficos
Autores principales: Stokes, William A., Behera, Madhusmita, Jiang, Renjian, Gutman, David A., Huang, Zhonglu, Burns, Abigail, Sebastian, Nikhil T., Sukhatme, Vidula, Lowe, Michael C., Ramalingam, Suresh S., Sukhatme, Vikas P., Moghanaki, Drew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
RESEARCH ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844615/
https://www.ncbi.nlm.nih.gov/pubmed/35607930
http://dx.doi.org/10.1002/cam4.4847

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