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Feasibility of a silicone vascular phantom replicating real arterial contrast filling dynamics on cerebral angiography: An in-vitro pilot study

Some cerebral arterial silicone phantoms have been used in preclinical evaluations. However, typical silicone-based phantoms are limited in their capacity to reproduce real contrast filling dynamics of the human cerebral artery. This study aimed to develop a cerebral arterial silicone phantom to ana...

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Autores principales: Lee, Ki Baek, Sheen, Jae Jon, Yoon, Jong-Tae, Kim, Mi Hyeon, Maeng, Jun Young, Hwang, Sun Moon, Choi, Joon Ho, Lee, Deok Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844885/
https://www.ncbi.nlm.nih.gov/pubmed/36649351
http://dx.doi.org/10.1371/journal.pone.0280395
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author Lee, Ki Baek
Sheen, Jae Jon
Yoon, Jong-Tae
Kim, Mi Hyeon
Maeng, Jun Young
Hwang, Sun Moon
Choi, Joon Ho
Lee, Deok Hee
author_facet Lee, Ki Baek
Sheen, Jae Jon
Yoon, Jong-Tae
Kim, Mi Hyeon
Maeng, Jun Young
Hwang, Sun Moon
Choi, Joon Ho
Lee, Deok Hee
author_sort Lee, Ki Baek
collection PubMed
description Some cerebral arterial silicone phantoms have been used in preclinical evaluations. However, typical silicone-based phantoms are limited in their capacity to reproduce real contrast filling dynamics of the human cerebral artery. This study aimed to develop a cerebral arterial silicone phantom to analyze the feasibility of real contrast filling dynamics. The fluid circulation phantom system consisted of a cerebral arterial silicone phantom without or with additional devices, a pump, an injection system, a pressure-monitoring system, a constant-temperature bath, and a venous drainage container. Vascular resistance was reproduced with a plastic cistern only or a plastic cistern filled with a sponge pad. Three phantom groups were constructed as follows: a) the cerebral arterial silicone phantom used as the control group (type A), b) phantom with the incorporated plastic cistern (type B), and c) phantom with the incorporated plastic cistern filled with a sponge pad (type C). The contrast concentration–time curve patterns of the three groups obtained from digital subtraction angiography (DSA) were compared. Consequently, the DSA pattern of the type C phantom was the most similar to that obtained from the control group as the reference data, which showed the broadest full-width-at-half-maximum and the area under the curve values and the highest maximum contrast concentration. In conclusion, we could emulate the arterial contrast filling dynamics of clinical cerebral angiography by applying a small cistern filled with a sponge pad at the drainage side of the phantom.
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spelling pubmed-98448852023-01-18 Feasibility of a silicone vascular phantom replicating real arterial contrast filling dynamics on cerebral angiography: An in-vitro pilot study Lee, Ki Baek Sheen, Jae Jon Yoon, Jong-Tae Kim, Mi Hyeon Maeng, Jun Young Hwang, Sun Moon Choi, Joon Ho Lee, Deok Hee PLoS One Research Article Some cerebral arterial silicone phantoms have been used in preclinical evaluations. However, typical silicone-based phantoms are limited in their capacity to reproduce real contrast filling dynamics of the human cerebral artery. This study aimed to develop a cerebral arterial silicone phantom to analyze the feasibility of real contrast filling dynamics. The fluid circulation phantom system consisted of a cerebral arterial silicone phantom without or with additional devices, a pump, an injection system, a pressure-monitoring system, a constant-temperature bath, and a venous drainage container. Vascular resistance was reproduced with a plastic cistern only or a plastic cistern filled with a sponge pad. Three phantom groups were constructed as follows: a) the cerebral arterial silicone phantom used as the control group (type A), b) phantom with the incorporated plastic cistern (type B), and c) phantom with the incorporated plastic cistern filled with a sponge pad (type C). The contrast concentration–time curve patterns of the three groups obtained from digital subtraction angiography (DSA) were compared. Consequently, the DSA pattern of the type C phantom was the most similar to that obtained from the control group as the reference data, which showed the broadest full-width-at-half-maximum and the area under the curve values and the highest maximum contrast concentration. In conclusion, we could emulate the arterial contrast filling dynamics of clinical cerebral angiography by applying a small cistern filled with a sponge pad at the drainage side of the phantom. Public Library of Science 2023-01-17 /pmc/articles/PMC9844885/ /pubmed/36649351 http://dx.doi.org/10.1371/journal.pone.0280395 Text en © 2023 Lee et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lee, Ki Baek
Sheen, Jae Jon
Yoon, Jong-Tae
Kim, Mi Hyeon
Maeng, Jun Young
Hwang, Sun Moon
Choi, Joon Ho
Lee, Deok Hee
Feasibility of a silicone vascular phantom replicating real arterial contrast filling dynamics on cerebral angiography: An in-vitro pilot study
title Feasibility of a silicone vascular phantom replicating real arterial contrast filling dynamics on cerebral angiography: An in-vitro pilot study
title_full Feasibility of a silicone vascular phantom replicating real arterial contrast filling dynamics on cerebral angiography: An in-vitro pilot study
title_fullStr Feasibility of a silicone vascular phantom replicating real arterial contrast filling dynamics on cerebral angiography: An in-vitro pilot study
title_full_unstemmed Feasibility of a silicone vascular phantom replicating real arterial contrast filling dynamics on cerebral angiography: An in-vitro pilot study
title_short Feasibility of a silicone vascular phantom replicating real arterial contrast filling dynamics on cerebral angiography: An in-vitro pilot study
title_sort feasibility of a silicone vascular phantom replicating real arterial contrast filling dynamics on cerebral angiography: an in-vitro pilot study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9844885/
https://www.ncbi.nlm.nih.gov/pubmed/36649351
http://dx.doi.org/10.1371/journal.pone.0280395
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