Protein kinase C(ι) and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities

We report that atypical protein kinase Cι (PKCι) is an oncogenic driver of glioblastoma (GBM). Deletion or inhibition of PKCι significantly impairs tumor growth and prolongs survival in murine GBM models. GBM cells expressing elevated PKCι signaling are sensitive to PKCι inhibitors, whereas those ex...

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Detalles Bibliográficos
Autores principales: Kenchappa, Rajappa S., Liu, Yi, Argenziano, Michael G., Banu, Matei A., Mladek, Ann C., West, Rita, Luu, Amanda, Quiñones-Hinojosa, Alfredo, Hambardzumyan, Dolores, Justilien, Verline, Leitges, Michael, Sarkaria, Jann N., Sims, Peter A., Canoll, Peter, Murray, Nicole R., Fields, Alan P., Rosenfeld, Steven S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845019/
https://www.ncbi.nlm.nih.gov/pubmed/34818553
http://dx.doi.org/10.1016/j.celrep.2021.110054

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