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Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population

PURPOSE: The health correlates of polygenic risk (PRS-SCZ) and exposome (ES-SCZ) scores for schizophrenia may vary depending on age and sex. We aimed to examine age- and sex-specific associations of PRS-SCZ and ES-SCZ with self-reported health in the general population. METHODS: Participants were fr...

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Autores principales: Paquin, Vincent, Pries, Lotta-Katrin, ten Have, Margreet, Bak, Maarten, Gunther, Nicole, de Graaf, Ron, van Dorsselaer, Saskia, Lin, Bochao D., van Eijk, Kristel R., Kenis, Gunter, Richards, Alexander, O’Donovan, Michael C., Luykx, Jurjen J., Rutten, Bart P. F., van Os, Jim, Shah, Jai L., Guloksuz, Sinan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845157/
https://www.ncbi.nlm.nih.gov/pubmed/35913550
http://dx.doi.org/10.1007/s00127-022-02346-3
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author Paquin, Vincent
Pries, Lotta-Katrin
ten Have, Margreet
Bak, Maarten
Gunther, Nicole
de Graaf, Ron
van Dorsselaer, Saskia
Lin, Bochao D.
van Eijk, Kristel R.
Kenis, Gunter
Richards, Alexander
O’Donovan, Michael C.
Luykx, Jurjen J.
Rutten, Bart P. F.
van Os, Jim
Shah, Jai L.
Guloksuz, Sinan
author_facet Paquin, Vincent
Pries, Lotta-Katrin
ten Have, Margreet
Bak, Maarten
Gunther, Nicole
de Graaf, Ron
van Dorsselaer, Saskia
Lin, Bochao D.
van Eijk, Kristel R.
Kenis, Gunter
Richards, Alexander
O’Donovan, Michael C.
Luykx, Jurjen J.
Rutten, Bart P. F.
van Os, Jim
Shah, Jai L.
Guloksuz, Sinan
author_sort Paquin, Vincent
collection PubMed
description PURPOSE: The health correlates of polygenic risk (PRS-SCZ) and exposome (ES-SCZ) scores for schizophrenia may vary depending on age and sex. We aimed to examine age- and sex-specific associations of PRS-SCZ and ES-SCZ with self-reported health in the general population. METHODS: Participants were from the population-based Netherlands Mental Health Survey and Incidence Study–2 (NEMESIS-2). Mental and physical health were measured with the 36-item Short Form Survey 4 times between 2007 and 2018. The PRS-SCZ and ES-SCZ were respectively calculated from common genetic variants and exposures (cannabis use, winter birth, hearing impairment, and five childhood adversity categories). Moderation by age and sex was examined in linear mixed models. RESULTS: For PRS-SCZ and ES-SCZ analyses, we included 3099 and 6264 participants, respectively (age range 18–65 years; 55.7–56.1% female). Age and sex did not interact with PRS-SCZ. Age moderated the association between ES-SCZ and mental (interaction: p = 0.02) and physical health (p = 0.0007): at age 18, + 1.00 of ES-SCZ was associated with − 0.10 of mental health and − 0.08 of physical health, whereas at age 65, it was associated with − 0.21 and − 0.23, respectively (all units in standard deviations). Sex moderated the association between ES-SCZ and physical health (p < .0001): + 1.00 of ES-SCZ was associated with − 0.19 of physical health among female and − 0.11 among male individuals. CONCLUSION: There were larger associations between higher ES-SCZ and poorer health among female and older individuals. Accounting for these interactions may increase ES-SCZ precision and help uncover populational determinants of environmental influences on health. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00127-022-02346-3.
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spelling pubmed-98451572023-01-19 Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population Paquin, Vincent Pries, Lotta-Katrin ten Have, Margreet Bak, Maarten Gunther, Nicole de Graaf, Ron van Dorsselaer, Saskia Lin, Bochao D. van Eijk, Kristel R. Kenis, Gunter Richards, Alexander O’Donovan, Michael C. Luykx, Jurjen J. Rutten, Bart P. F. van Os, Jim Shah, Jai L. Guloksuz, Sinan Soc Psychiatry Psychiatr Epidemiol Original Paper PURPOSE: The health correlates of polygenic risk (PRS-SCZ) and exposome (ES-SCZ) scores for schizophrenia may vary depending on age and sex. We aimed to examine age- and sex-specific associations of PRS-SCZ and ES-SCZ with self-reported health in the general population. METHODS: Participants were from the population-based Netherlands Mental Health Survey and Incidence Study–2 (NEMESIS-2). Mental and physical health were measured with the 36-item Short Form Survey 4 times between 2007 and 2018. The PRS-SCZ and ES-SCZ were respectively calculated from common genetic variants and exposures (cannabis use, winter birth, hearing impairment, and five childhood adversity categories). Moderation by age and sex was examined in linear mixed models. RESULTS: For PRS-SCZ and ES-SCZ analyses, we included 3099 and 6264 participants, respectively (age range 18–65 years; 55.7–56.1% female). Age and sex did not interact with PRS-SCZ. Age moderated the association between ES-SCZ and mental (interaction: p = 0.02) and physical health (p = 0.0007): at age 18, + 1.00 of ES-SCZ was associated with − 0.10 of mental health and − 0.08 of physical health, whereas at age 65, it was associated with − 0.21 and − 0.23, respectively (all units in standard deviations). Sex moderated the association between ES-SCZ and physical health (p < .0001): + 1.00 of ES-SCZ was associated with − 0.19 of physical health among female and − 0.11 among male individuals. CONCLUSION: There were larger associations between higher ES-SCZ and poorer health among female and older individuals. Accounting for these interactions may increase ES-SCZ precision and help uncover populational determinants of environmental influences on health. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00127-022-02346-3. Springer Berlin Heidelberg 2022-08-01 2023 /pmc/articles/PMC9845157/ /pubmed/35913550 http://dx.doi.org/10.1007/s00127-022-02346-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Paquin, Vincent
Pries, Lotta-Katrin
ten Have, Margreet
Bak, Maarten
Gunther, Nicole
de Graaf, Ron
van Dorsselaer, Saskia
Lin, Bochao D.
van Eijk, Kristel R.
Kenis, Gunter
Richards, Alexander
O’Donovan, Michael C.
Luykx, Jurjen J.
Rutten, Bart P. F.
van Os, Jim
Shah, Jai L.
Guloksuz, Sinan
Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population
title Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population
title_full Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population
title_fullStr Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population
title_full_unstemmed Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population
title_short Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population
title_sort age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845157/
https://www.ncbi.nlm.nih.gov/pubmed/35913550
http://dx.doi.org/10.1007/s00127-022-02346-3
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