Tumor-intrinsic YTHDF1 drives immune evasion and resistance to immune checkpoint inhibitors via promoting MHC-I degradation

The recently described role of RNA methylation in regulating immune cell infiltration into tumors has attracted interest, given its potential impact on immunotherapy response. YTHDF1 is a versatile and powerful m6A reader, but the understanding of its impact on immune evasion is limited. Here, we re...

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Detalles Bibliográficos
Autores principales: Lin, Wanzun, Chen, Li, Zhang, Haojiong, Qiu, Xianxin, Huang, Qingting, Wan, Fangzhu, Le, Ziyu, Geng, Shikai, Zhang, Anlan, Qiu, Sufang, Chen, Long, Kong, Lin, Lu, Jiade J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845301/
https://www.ncbi.nlm.nih.gov/pubmed/36650153
http://dx.doi.org/10.1038/s41467-022-35710-7

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