Cargando…
Association between sarcopenia and clinical outcomes in patients with hepatocellular carcinoma: an updated meta-analysis
Although numerous studies have reported the association between sarcopenia and the prognosis of hepatocellular carcinoma (HCC) patients, there is lack of a newer and more comprehensive meta-analysis. Herein, a comprehensive literature search was performed on PubMed, Web of Science, the Cochrane Libr...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845331/ https://www.ncbi.nlm.nih.gov/pubmed/36650190 http://dx.doi.org/10.1038/s41598-022-27238-z |
_version_ | 1784870880567885824 |
---|---|
author | Guo, Yusheng Ren, Yanqiao Zhu, Licheng Yang, Lian Zheng, Chuansheng |
author_facet | Guo, Yusheng Ren, Yanqiao Zhu, Licheng Yang, Lian Zheng, Chuansheng |
author_sort | Guo, Yusheng |
collection | PubMed |
description | Although numerous studies have reported the association between sarcopenia and the prognosis of hepatocellular carcinoma (HCC) patients, there is lack of a newer and more comprehensive meta-analysis. Herein, a comprehensive literature search was performed on PubMed, Web of Science, the Cochrane Library, and Embase databases to identify relevant studies published up to February 2022. The outcomes were overall survival (OS), recurrence, progression‐free survival, tumor response, severe postoperative complications, and toxicity of drugs. A total of 57 studies involving 9790 HCC patients were included in the meta-analysis. The pooled prevalence of sarcopenia in HCC patients was 41.7% (95% CI 36.2–47.2%). Results demonstrated that sarcopenia was significantly associated with impaired OS (HR: 1.93, 95% CI 1.73–2.17, P < 0.001), higher risk of tumor recurrence (HR: 1.75, 95% CI 1.56–1.96, P < 0.001), lower objective response rate (OR: 0.37 95% CI 0.17–0.81, P = 0.012), and more drug-related adverse events (OR: 2.23, 95% CI 1.17–4.28, P = 0.015) in HCC patients. The subgroup analyses revealed that the OS of patients at the early stage of tumor was more severely affected by sarcopenia than for patients at other stages. Moreover, the presence of cirrhosis and Child Pugh class B increased the hazard of mortality from sarcopenia. This study has shown that sarcopenia is highly associated with poor prognosis in HCC patients. In addition, cirrhosis and poor liver functional reserve increase the danger of sarcopenia. OS was more impaired in HCC patients with sarcopenia at early stage of tumor than at other tumor stages. |
format | Online Article Text |
id | pubmed-9845331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-98453312023-01-19 Association between sarcopenia and clinical outcomes in patients with hepatocellular carcinoma: an updated meta-analysis Guo, Yusheng Ren, Yanqiao Zhu, Licheng Yang, Lian Zheng, Chuansheng Sci Rep Article Although numerous studies have reported the association between sarcopenia and the prognosis of hepatocellular carcinoma (HCC) patients, there is lack of a newer and more comprehensive meta-analysis. Herein, a comprehensive literature search was performed on PubMed, Web of Science, the Cochrane Library, and Embase databases to identify relevant studies published up to February 2022. The outcomes were overall survival (OS), recurrence, progression‐free survival, tumor response, severe postoperative complications, and toxicity of drugs. A total of 57 studies involving 9790 HCC patients were included in the meta-analysis. The pooled prevalence of sarcopenia in HCC patients was 41.7% (95% CI 36.2–47.2%). Results demonstrated that sarcopenia was significantly associated with impaired OS (HR: 1.93, 95% CI 1.73–2.17, P < 0.001), higher risk of tumor recurrence (HR: 1.75, 95% CI 1.56–1.96, P < 0.001), lower objective response rate (OR: 0.37 95% CI 0.17–0.81, P = 0.012), and more drug-related adverse events (OR: 2.23, 95% CI 1.17–4.28, P = 0.015) in HCC patients. The subgroup analyses revealed that the OS of patients at the early stage of tumor was more severely affected by sarcopenia than for patients at other stages. Moreover, the presence of cirrhosis and Child Pugh class B increased the hazard of mortality from sarcopenia. This study has shown that sarcopenia is highly associated with poor prognosis in HCC patients. In addition, cirrhosis and poor liver functional reserve increase the danger of sarcopenia. OS was more impaired in HCC patients with sarcopenia at early stage of tumor than at other tumor stages. Nature Publishing Group UK 2023-01-17 /pmc/articles/PMC9845331/ /pubmed/36650190 http://dx.doi.org/10.1038/s41598-022-27238-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Guo, Yusheng Ren, Yanqiao Zhu, Licheng Yang, Lian Zheng, Chuansheng Association between sarcopenia and clinical outcomes in patients with hepatocellular carcinoma: an updated meta-analysis |
title | Association between sarcopenia and clinical outcomes in patients with hepatocellular carcinoma: an updated meta-analysis |
title_full | Association between sarcopenia and clinical outcomes in patients with hepatocellular carcinoma: an updated meta-analysis |
title_fullStr | Association between sarcopenia and clinical outcomes in patients with hepatocellular carcinoma: an updated meta-analysis |
title_full_unstemmed | Association between sarcopenia and clinical outcomes in patients with hepatocellular carcinoma: an updated meta-analysis |
title_short | Association between sarcopenia and clinical outcomes in patients with hepatocellular carcinoma: an updated meta-analysis |
title_sort | association between sarcopenia and clinical outcomes in patients with hepatocellular carcinoma: an updated meta-analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845331/ https://www.ncbi.nlm.nih.gov/pubmed/36650190 http://dx.doi.org/10.1038/s41598-022-27238-z |
work_keys_str_mv | AT guoyusheng associationbetweensarcopeniaandclinicaloutcomesinpatientswithhepatocellularcarcinomaanupdatedmetaanalysis AT renyanqiao associationbetweensarcopeniaandclinicaloutcomesinpatientswithhepatocellularcarcinomaanupdatedmetaanalysis AT zhulicheng associationbetweensarcopeniaandclinicaloutcomesinpatientswithhepatocellularcarcinomaanupdatedmetaanalysis AT yanglian associationbetweensarcopeniaandclinicaloutcomesinpatientswithhepatocellularcarcinomaanupdatedmetaanalysis AT zhengchuansheng associationbetweensarcopeniaandclinicaloutcomesinpatientswithhepatocellularcarcinomaanupdatedmetaanalysis |