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Deciphering the exact breakpoints of structural variations using long sequencing reads with DeBreak

Long-read sequencing has demonstrated great potential for characterizing all types of structural variations (SVs). However, existing algorithms have insufficient sensitivity and precision. To address these limitations, we present DeBreak, a computational method for comprehensive and accurate SV disc...

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Detalles Bibliográficos
Autores principales:	Chen, Yu, Wang, Amy Y., Barkley, Courtney A., Zhang, Yixin, Zhao, Xinyang, Gao, Min, Edmonds, Mick D., Chong, Zechen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845341/ https://www.ncbi.nlm.nih.gov/pubmed/36650186 http://dx.doi.org/10.1038/s41467-023-35996-1

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