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Finding shortest and nearly shortest path nodes in large substantially incomplete networks by hyperbolic mapping

Dynamic processes on networks, be it information transfer in the Internet, contagious spreading in a social network, or neural signaling, take place along shortest or nearly shortest paths. Computing shortest paths is a straightforward task when the network of interest is fully known, and there are...

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Autores principales: Kitsak, Maksim, Ganin, Alexander, Elmokashfi, Ahmed, Cui, Hongzhu, Eisenberg, Daniel A., Alderson, David L., Korkin, Dmitry, Linkov, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845360/
https://www.ncbi.nlm.nih.gov/pubmed/36650144
http://dx.doi.org/10.1038/s41467-022-35181-w
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author Kitsak, Maksim
Ganin, Alexander
Elmokashfi, Ahmed
Cui, Hongzhu
Eisenberg, Daniel A.
Alderson, David L.
Korkin, Dmitry
Linkov, Igor
author_facet Kitsak, Maksim
Ganin, Alexander
Elmokashfi, Ahmed
Cui, Hongzhu
Eisenberg, Daniel A.
Alderson, David L.
Korkin, Dmitry
Linkov, Igor
author_sort Kitsak, Maksim
collection PubMed
description Dynamic processes on networks, be it information transfer in the Internet, contagious spreading in a social network, or neural signaling, take place along shortest or nearly shortest paths. Computing shortest paths is a straightforward task when the network of interest is fully known, and there are a plethora of computational algorithms for this purpose. Unfortunately, our maps of most large networks are substantially incomplete due to either the highly dynamic nature of networks, or high cost of network measurements, or both, rendering traditional path finding methods inefficient. We find that shortest paths in large real networks, such as the network of protein-protein interactions and the Internet at the autonomous system level, are not random but are organized according to latent-geometric rules. If nodes of these networks are mapped to points in latent hyperbolic spaces, shortest paths in them align along geodesic curves connecting endpoint nodes. We find that this alignment is sufficiently strong to allow for the identification of shortest path nodes even in the case of substantially incomplete networks, where numbers of missing links exceed those of observable links. We demonstrate the utility of latent-geometric path finding in problems of cellular pathway reconstruction and communication security.
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spelling pubmed-98453602023-01-19 Finding shortest and nearly shortest path nodes in large substantially incomplete networks by hyperbolic mapping Kitsak, Maksim Ganin, Alexander Elmokashfi, Ahmed Cui, Hongzhu Eisenberg, Daniel A. Alderson, David L. Korkin, Dmitry Linkov, Igor Nat Commun Article Dynamic processes on networks, be it information transfer in the Internet, contagious spreading in a social network, or neural signaling, take place along shortest or nearly shortest paths. Computing shortest paths is a straightforward task when the network of interest is fully known, and there are a plethora of computational algorithms for this purpose. Unfortunately, our maps of most large networks are substantially incomplete due to either the highly dynamic nature of networks, or high cost of network measurements, or both, rendering traditional path finding methods inefficient. We find that shortest paths in large real networks, such as the network of protein-protein interactions and the Internet at the autonomous system level, are not random but are organized according to latent-geometric rules. If nodes of these networks are mapped to points in latent hyperbolic spaces, shortest paths in them align along geodesic curves connecting endpoint nodes. We find that this alignment is sufficiently strong to allow for the identification of shortest path nodes even in the case of substantially incomplete networks, where numbers of missing links exceed those of observable links. We demonstrate the utility of latent-geometric path finding in problems of cellular pathway reconstruction and communication security. Nature Publishing Group UK 2023-01-17 /pmc/articles/PMC9845360/ /pubmed/36650144 http://dx.doi.org/10.1038/s41467-022-35181-w Text en © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kitsak, Maksim
Ganin, Alexander
Elmokashfi, Ahmed
Cui, Hongzhu
Eisenberg, Daniel A.
Alderson, David L.
Korkin, Dmitry
Linkov, Igor
Finding shortest and nearly shortest path nodes in large substantially incomplete networks by hyperbolic mapping
title Finding shortest and nearly shortest path nodes in large substantially incomplete networks by hyperbolic mapping
title_full Finding shortest and nearly shortest path nodes in large substantially incomplete networks by hyperbolic mapping
title_fullStr Finding shortest and nearly shortest path nodes in large substantially incomplete networks by hyperbolic mapping
title_full_unstemmed Finding shortest and nearly shortest path nodes in large substantially incomplete networks by hyperbolic mapping
title_short Finding shortest and nearly shortest path nodes in large substantially incomplete networks by hyperbolic mapping
title_sort finding shortest and nearly shortest path nodes in large substantially incomplete networks by hyperbolic mapping
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845360/
https://www.ncbi.nlm.nih.gov/pubmed/36650144
http://dx.doi.org/10.1038/s41467-022-35181-w
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