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Genome-wide exploration of a pyroptosis-related gene module along with immune cell infiltration patterns in bronchopulmonary dysplasia
Pyroptosis plays a crucial role in bronchopulmonary dysplasia (BPD) and is associated with various lung injury illnesses. However, the function of pyroptosis-related genes (PRGs) in BPD remains poorly understood. The gene expression omnibus (GEO) database was searched for information on genes associ...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845403/ https://www.ncbi.nlm.nih.gov/pubmed/36685920 http://dx.doi.org/10.3389/fgene.2022.1074723 |
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author | Chen, Leiming Shi, Chaofan Zhou, Guoping Yang, Xiaofeng Xiong, Zhenqin Ma, Xiaoxue Zhu, Lan Ma, Xuejiao Mao, Yan Hu, Yifang Wang, Jimei Tang, Xinfang Bao, Yunlei Ma, Yunxia Luo, Fei Wu, Chuyan Jiang, Feng |
author_facet | Chen, Leiming Shi, Chaofan Zhou, Guoping Yang, Xiaofeng Xiong, Zhenqin Ma, Xiaoxue Zhu, Lan Ma, Xuejiao Mao, Yan Hu, Yifang Wang, Jimei Tang, Xinfang Bao, Yunlei Ma, Yunxia Luo, Fei Wu, Chuyan Jiang, Feng |
author_sort | Chen, Leiming |
collection | PubMed |
description | Pyroptosis plays a crucial role in bronchopulmonary dysplasia (BPD) and is associated with various lung injury illnesses. However, the function of pyroptosis-related genes (PRGs) in BPD remains poorly understood. The gene expression omnibus (GEO) database was searched for information on genes associated with BPD. Twenty-five BPD-related DE-PRGs were identified, all of which were closely associated with pyroptosis regulation and immunological response. LASSO and SVM-RFE algorithms identified CHMP7, NLRC4, NLRP2, NLRP6, and NLRP9 among the 25 differentially expressed PRGs as marker genes with acceptable diagnostic capabilities. Using these five genes, we also generated a nomogram with excellent predictive power. Annotation enrichment analyses revealed that these five genes may be implicated in BPD and numerous BPD-related pathways. In addition, the ceRNA network showed an intricate regulatory link based on the marker genes. In addition, CIBERSORT-based studies revealed that alterations in the immunological microenvironment of BPD patients may be associated with the marker genes. We constructed a diagnostic nomogram and gave insight into the mechanism of BPD. Its diagnostic value for BPD must be evaluated in further research before it can be used in clinical practice. |
format | Online Article Text |
id | pubmed-9845403 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98454032023-01-19 Genome-wide exploration of a pyroptosis-related gene module along with immune cell infiltration patterns in bronchopulmonary dysplasia Chen, Leiming Shi, Chaofan Zhou, Guoping Yang, Xiaofeng Xiong, Zhenqin Ma, Xiaoxue Zhu, Lan Ma, Xuejiao Mao, Yan Hu, Yifang Wang, Jimei Tang, Xinfang Bao, Yunlei Ma, Yunxia Luo, Fei Wu, Chuyan Jiang, Feng Front Genet Genetics Pyroptosis plays a crucial role in bronchopulmonary dysplasia (BPD) and is associated with various lung injury illnesses. However, the function of pyroptosis-related genes (PRGs) in BPD remains poorly understood. The gene expression omnibus (GEO) database was searched for information on genes associated with BPD. Twenty-five BPD-related DE-PRGs were identified, all of which were closely associated with pyroptosis regulation and immunological response. LASSO and SVM-RFE algorithms identified CHMP7, NLRC4, NLRP2, NLRP6, and NLRP9 among the 25 differentially expressed PRGs as marker genes with acceptable diagnostic capabilities. Using these five genes, we also generated a nomogram with excellent predictive power. Annotation enrichment analyses revealed that these five genes may be implicated in BPD and numerous BPD-related pathways. In addition, the ceRNA network showed an intricate regulatory link based on the marker genes. In addition, CIBERSORT-based studies revealed that alterations in the immunological microenvironment of BPD patients may be associated with the marker genes. We constructed a diagnostic nomogram and gave insight into the mechanism of BPD. Its diagnostic value for BPD must be evaluated in further research before it can be used in clinical practice. Frontiers Media S.A. 2023-01-04 /pmc/articles/PMC9845403/ /pubmed/36685920 http://dx.doi.org/10.3389/fgene.2022.1074723 Text en Copyright © 2023 Chen, Shi, Zhou, Yang, Xiong, Ma, Zhu, Ma, Mao, Hu, Wang, Tang, Bao, Ma, Luo, Wu and Jiang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Chen, Leiming Shi, Chaofan Zhou, Guoping Yang, Xiaofeng Xiong, Zhenqin Ma, Xiaoxue Zhu, Lan Ma, Xuejiao Mao, Yan Hu, Yifang Wang, Jimei Tang, Xinfang Bao, Yunlei Ma, Yunxia Luo, Fei Wu, Chuyan Jiang, Feng Genome-wide exploration of a pyroptosis-related gene module along with immune cell infiltration patterns in bronchopulmonary dysplasia |
title | Genome-wide exploration of a pyroptosis-related gene module along with immune cell infiltration patterns in bronchopulmonary dysplasia |
title_full | Genome-wide exploration of a pyroptosis-related gene module along with immune cell infiltration patterns in bronchopulmonary dysplasia |
title_fullStr | Genome-wide exploration of a pyroptosis-related gene module along with immune cell infiltration patterns in bronchopulmonary dysplasia |
title_full_unstemmed | Genome-wide exploration of a pyroptosis-related gene module along with immune cell infiltration patterns in bronchopulmonary dysplasia |
title_short | Genome-wide exploration of a pyroptosis-related gene module along with immune cell infiltration patterns in bronchopulmonary dysplasia |
title_sort | genome-wide exploration of a pyroptosis-related gene module along with immune cell infiltration patterns in bronchopulmonary dysplasia |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845403/ https://www.ncbi.nlm.nih.gov/pubmed/36685920 http://dx.doi.org/10.3389/fgene.2022.1074723 |
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