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Effect of the 3q26-coding oncogene SEC62 as a potential prognostic marker in patients with ovarian neoplasia

With approximately 220,000 newly diagnosed cases per year, ovarian cancer is among the most frequently occurring cancers among women and the second leading cause of death from gynecological malignancies worldwide. About 70% of these cancers are diagnosed in advanced stages (FIGO IIB–IV), with a 5-ye...

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Autores principales: Radosa, Julia C., Kasoha, Mariz, Schilz, Anne-Christine, Takacs, Zoltan F., Kaya, Askin, Radosa, Marc P., Linxweiler, Barbara, Linxweiler, Maximilian, Bohle, Rainer M., Wagner, Mathias, Wagenpfeil, Gudrun, Solomayer, Erich-Franz, Zimmermann, Julia S. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845558/
https://www.ncbi.nlm.nih.gov/pubmed/36685175
http://dx.doi.org/10.3389/fphys.2022.1054508
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author Radosa, Julia C.
Kasoha, Mariz
Schilz, Anne-Christine
Takacs, Zoltan F.
Kaya, Askin
Radosa, Marc P.
Linxweiler, Barbara
Linxweiler, Maximilian
Bohle, Rainer M.
Wagner, Mathias
Wagenpfeil, Gudrun
Solomayer, Erich-Franz
Zimmermann, Julia S. M.
author_facet Radosa, Julia C.
Kasoha, Mariz
Schilz, Anne-Christine
Takacs, Zoltan F.
Kaya, Askin
Radosa, Marc P.
Linxweiler, Barbara
Linxweiler, Maximilian
Bohle, Rainer M.
Wagner, Mathias
Wagenpfeil, Gudrun
Solomayer, Erich-Franz
Zimmermann, Julia S. M.
author_sort Radosa, Julia C.
collection PubMed
description With approximately 220,000 newly diagnosed cases per year, ovarian cancer is among the most frequently occurring cancers among women and the second leading cause of death from gynecological malignancies worldwide. About 70% of these cancers are diagnosed in advanced stages (FIGO IIB–IV), with a 5-year survival rate of 20–30%. Due to the poor prognosis of this disease, research has focused on its pathogenesis and the identification of prognostic factors. One possible approach for the identification of biological markers is the identification of tumor entity-specific genetic “driver mutations”. One such mutation is 3q26 amplification in the tumor driver SEC62, which has been identified as relevant to the pathogenesis of ovarian cancer. This study was conducted to investigate the role of SEC62 in ovarian malignancies. Patients with ovarian neoplasias (borderline tumors of the ovary and ovarian cancer) who were treated between January 2007 and April 2019 at the Department of Gynecology and Obstetrics, Saarland University Hospital, were included in this retrospective study. SEC62 expression in tumor tissue samples taken during clinical treatment was assessed immunohistochemically, with the calculation of immunoreactivity scores according to Remmele and Stegner, Pathologe, 1987, 8, 138–140. Correlations of SEC62 expression with the TNM stage, histological subtype, tumor entity, and oncological outcomes (progression-free and overall survival) were examined. The sample comprised 167 patients (123 with ovarian cancer and 44 with borderline tumors of the ovary) with a median age of 60 (range, 15–87) years. At the time of diagnosis, 77 (46%) cases were FIGO stage III. All tissue slides showed SEC62 overexpression in tumor cells and no SEC62 expression in other cells. Median immunoreactivity scores were 8 (range, 2–12) for ovarian cancer and 9 (range, 4–12) for borderline tumors of the ovary. Patients with borderline tumors of the ovary as well as patients with ovarian cancer and an immunoreactive score (IRS) ≤ 9 showed an improved overall survival compared to those presenting with an IRS score >9 (p = 0.03). SEC62 seems to be a prognostic biomarker for the overall survival of patients with ovarian malignancies.
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spelling pubmed-98455582023-01-19 Effect of the 3q26-coding oncogene SEC62 as a potential prognostic marker in patients with ovarian neoplasia Radosa, Julia C. Kasoha, Mariz Schilz, Anne-Christine Takacs, Zoltan F. Kaya, Askin Radosa, Marc P. Linxweiler, Barbara Linxweiler, Maximilian Bohle, Rainer M. Wagner, Mathias Wagenpfeil, Gudrun Solomayer, Erich-Franz Zimmermann, Julia S. M. Front Physiol Physiology With approximately 220,000 newly diagnosed cases per year, ovarian cancer is among the most frequently occurring cancers among women and the second leading cause of death from gynecological malignancies worldwide. About 70% of these cancers are diagnosed in advanced stages (FIGO IIB–IV), with a 5-year survival rate of 20–30%. Due to the poor prognosis of this disease, research has focused on its pathogenesis and the identification of prognostic factors. One possible approach for the identification of biological markers is the identification of tumor entity-specific genetic “driver mutations”. One such mutation is 3q26 amplification in the tumor driver SEC62, which has been identified as relevant to the pathogenesis of ovarian cancer. This study was conducted to investigate the role of SEC62 in ovarian malignancies. Patients with ovarian neoplasias (borderline tumors of the ovary and ovarian cancer) who were treated between January 2007 and April 2019 at the Department of Gynecology and Obstetrics, Saarland University Hospital, were included in this retrospective study. SEC62 expression in tumor tissue samples taken during clinical treatment was assessed immunohistochemically, with the calculation of immunoreactivity scores according to Remmele and Stegner, Pathologe, 1987, 8, 138–140. Correlations of SEC62 expression with the TNM stage, histological subtype, tumor entity, and oncological outcomes (progression-free and overall survival) were examined. The sample comprised 167 patients (123 with ovarian cancer and 44 with borderline tumors of the ovary) with a median age of 60 (range, 15–87) years. At the time of diagnosis, 77 (46%) cases were FIGO stage III. All tissue slides showed SEC62 overexpression in tumor cells and no SEC62 expression in other cells. Median immunoreactivity scores were 8 (range, 2–12) for ovarian cancer and 9 (range, 4–12) for borderline tumors of the ovary. Patients with borderline tumors of the ovary as well as patients with ovarian cancer and an immunoreactive score (IRS) ≤ 9 showed an improved overall survival compared to those presenting with an IRS score >9 (p = 0.03). SEC62 seems to be a prognostic biomarker for the overall survival of patients with ovarian malignancies. Frontiers Media S.A. 2023-01-04 /pmc/articles/PMC9845558/ /pubmed/36685175 http://dx.doi.org/10.3389/fphys.2022.1054508 Text en Copyright © 2023 Radosa, Kasoha, Schilz, Takacs, Kaya, Radosa, Linxweiler, Linxweiler, Bohle, Wagner, Wagenpfeil, Solomayer and Zimmermann. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Radosa, Julia C.
Kasoha, Mariz
Schilz, Anne-Christine
Takacs, Zoltan F.
Kaya, Askin
Radosa, Marc P.
Linxweiler, Barbara
Linxweiler, Maximilian
Bohle, Rainer M.
Wagner, Mathias
Wagenpfeil, Gudrun
Solomayer, Erich-Franz
Zimmermann, Julia S. M.
Effect of the 3q26-coding oncogene SEC62 as a potential prognostic marker in patients with ovarian neoplasia
title Effect of the 3q26-coding oncogene SEC62 as a potential prognostic marker in patients with ovarian neoplasia
title_full Effect of the 3q26-coding oncogene SEC62 as a potential prognostic marker in patients with ovarian neoplasia
title_fullStr Effect of the 3q26-coding oncogene SEC62 as a potential prognostic marker in patients with ovarian neoplasia
title_full_unstemmed Effect of the 3q26-coding oncogene SEC62 as a potential prognostic marker in patients with ovarian neoplasia
title_short Effect of the 3q26-coding oncogene SEC62 as a potential prognostic marker in patients with ovarian neoplasia
title_sort effect of the 3q26-coding oncogene sec62 as a potential prognostic marker in patients with ovarian neoplasia
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845558/
https://www.ncbi.nlm.nih.gov/pubmed/36685175
http://dx.doi.org/10.3389/fphys.2022.1054508
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