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Vascular smooth muscle cells in intimal hyperplasia, an update

Arterial occlusive disease is the leading cause of death in Western countries. Core contemporary therapies for this disease include angioplasties, stents, endarterectomies and bypass surgery. However, these treatments suffer from high failure rates due to re-occlusive vascular wall adaptations and r...

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Autores principales: Déglise, Sébastien, Bechelli, Clémence, Allagnat, Florent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845604/
https://www.ncbi.nlm.nih.gov/pubmed/36685215
http://dx.doi.org/10.3389/fphys.2022.1081881
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author Déglise, Sébastien
Bechelli, Clémence
Allagnat, Florent
author_facet Déglise, Sébastien
Bechelli, Clémence
Allagnat, Florent
author_sort Déglise, Sébastien
collection PubMed
description Arterial occlusive disease is the leading cause of death in Western countries. Core contemporary therapies for this disease include angioplasties, stents, endarterectomies and bypass surgery. However, these treatments suffer from high failure rates due to re-occlusive vascular wall adaptations and restenosis. Restenosis following vascular surgery is largely due to intimal hyperplasia. Intimal hyperplasia develops in response to vessel injury, leading to inflammation, vascular smooth muscle cells dedifferentiation, migration, proliferation and secretion of extra-cellular matrix into the vessel’s innermost layer or intima. In this review, we describe the current state of knowledge on the origin and mechanisms underlying the dysregulated proliferation of vascular smooth muscle cells in intimal hyperplasia, and we present the new avenues of research targeting VSMC phenotype and proliferation.
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spelling pubmed-98456042023-01-19 Vascular smooth muscle cells in intimal hyperplasia, an update Déglise, Sébastien Bechelli, Clémence Allagnat, Florent Front Physiol Physiology Arterial occlusive disease is the leading cause of death in Western countries. Core contemporary therapies for this disease include angioplasties, stents, endarterectomies and bypass surgery. However, these treatments suffer from high failure rates due to re-occlusive vascular wall adaptations and restenosis. Restenosis following vascular surgery is largely due to intimal hyperplasia. Intimal hyperplasia develops in response to vessel injury, leading to inflammation, vascular smooth muscle cells dedifferentiation, migration, proliferation and secretion of extra-cellular matrix into the vessel’s innermost layer or intima. In this review, we describe the current state of knowledge on the origin and mechanisms underlying the dysregulated proliferation of vascular smooth muscle cells in intimal hyperplasia, and we present the new avenues of research targeting VSMC phenotype and proliferation. Frontiers Media S.A. 2023-01-04 /pmc/articles/PMC9845604/ /pubmed/36685215 http://dx.doi.org/10.3389/fphys.2022.1081881 Text en Copyright © 2023 Déglise, Bechelli and Allagnat. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Déglise, Sébastien
Bechelli, Clémence
Allagnat, Florent
Vascular smooth muscle cells in intimal hyperplasia, an update
title Vascular smooth muscle cells in intimal hyperplasia, an update
title_full Vascular smooth muscle cells in intimal hyperplasia, an update
title_fullStr Vascular smooth muscle cells in intimal hyperplasia, an update
title_full_unstemmed Vascular smooth muscle cells in intimal hyperplasia, an update
title_short Vascular smooth muscle cells in intimal hyperplasia, an update
title_sort vascular smooth muscle cells in intimal hyperplasia, an update
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845604/
https://www.ncbi.nlm.nih.gov/pubmed/36685215
http://dx.doi.org/10.3389/fphys.2022.1081881
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