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Wnt signaling in liver regeneration, disease, and cancer

The liver exhibits the highest recovery rate from acute injuries. However, in chronic liver disease, the long-term loss of hepatocytes often leads to adverse consequences such as fibrosis, cirrhosis, and liver cancer. The Wnt signaling plays a pivotal role in both liver regeneration and tumorigenesi...

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Detalles Bibliográficos
Autores principales: Zou, Gengyi, Park, Jae-Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association for the Study of the Liver 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845677/
https://www.ncbi.nlm.nih.gov/pubmed/35785913
http://dx.doi.org/10.3350/cmh.2022.0058
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author Zou, Gengyi
Park, Jae-Il
author_facet Zou, Gengyi
Park, Jae-Il
author_sort Zou, Gengyi
collection PubMed
description The liver exhibits the highest recovery rate from acute injuries. However, in chronic liver disease, the long-term loss of hepatocytes often leads to adverse consequences such as fibrosis, cirrhosis, and liver cancer. The Wnt signaling plays a pivotal role in both liver regeneration and tumorigenesis. Therefore, manipulating the Wnt signaling has become an attractive approach to treating liver disease, including cancer. Nonetheless, given the crucial roles of Wnt signaling in physiological processes, blocking Wnt signaling can also cause several adverse effects. Recent studies have identified cancer-specific regulators of Wnt signaling, which would overcome the limitation of Wnt signaling target approaches. In this review, we discussed the role of Wnt signaling in liver regeneration, precancerous lesion, and liver cancer. Furthermore, we summarized the basic and clinical approaches of Wnt signaling blockade and proposed the therapeutic prospects of cancer-specific Wnt signaling blockade for liver cancer treatment.
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spelling pubmed-98456772023-01-31 Wnt signaling in liver regeneration, disease, and cancer Zou, Gengyi Park, Jae-Il Clin Mol Hepatol Review The liver exhibits the highest recovery rate from acute injuries. However, in chronic liver disease, the long-term loss of hepatocytes often leads to adverse consequences such as fibrosis, cirrhosis, and liver cancer. The Wnt signaling plays a pivotal role in both liver regeneration and tumorigenesis. Therefore, manipulating the Wnt signaling has become an attractive approach to treating liver disease, including cancer. Nonetheless, given the crucial roles of Wnt signaling in physiological processes, blocking Wnt signaling can also cause several adverse effects. Recent studies have identified cancer-specific regulators of Wnt signaling, which would overcome the limitation of Wnt signaling target approaches. In this review, we discussed the role of Wnt signaling in liver regeneration, precancerous lesion, and liver cancer. Furthermore, we summarized the basic and clinical approaches of Wnt signaling blockade and proposed the therapeutic prospects of cancer-specific Wnt signaling blockade for liver cancer treatment. The Korean Association for the Study of the Liver 2023-01 2022-07-04 /pmc/articles/PMC9845677/ /pubmed/35785913 http://dx.doi.org/10.3350/cmh.2022.0058 Text en Copyright © 2023 by The Korean Association for the Study of the Liver https://creativecommons.org/licenses/by-nc/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Zou, Gengyi
Park, Jae-Il
Wnt signaling in liver regeneration, disease, and cancer
title Wnt signaling in liver regeneration, disease, and cancer
title_full Wnt signaling in liver regeneration, disease, and cancer
title_fullStr Wnt signaling in liver regeneration, disease, and cancer
title_full_unstemmed Wnt signaling in liver regeneration, disease, and cancer
title_short Wnt signaling in liver regeneration, disease, and cancer
title_sort wnt signaling in liver regeneration, disease, and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845677/
https://www.ncbi.nlm.nih.gov/pubmed/35785913
http://dx.doi.org/10.3350/cmh.2022.0058
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