Cargando…
Assessment of the prognostic value of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in perihilar cholangiocarcinoma patients following curative resection: A multicenter study of 333 patients
BACKGROUND & AIMS: Tumor-associated chronic inflammation has been determined to play a crucial role in tumor progression, angiogenesis and immunosuppression. The objective of this study was to assess the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte rati...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845724/ https://www.ncbi.nlm.nih.gov/pubmed/36686802 http://dx.doi.org/10.3389/fonc.2022.1104810 |
_version_ | 1784870974393417728 |
---|---|
author | Ge, Ming-Yang Liu, Zhi-Peng Pan, Yu Wang, Jiao-Yang Wang, Xiang Dai, Hai-Su Gao, Shu-Yang Zhong, Shi-Yun Che, Xiao-Yu Zuo, Jing-Hua Liu, Yun-Hua Liu, Xing-Chao Fan, Hai-Ning Chen, Wei-Yue Wang, Zi-Ran Yin, Xian-Yu Bai, Jie Zhang, Yan-Qi Jiang, Yan Gong, Yi Chen, Zhi-Yu |
author_facet | Ge, Ming-Yang Liu, Zhi-Peng Pan, Yu Wang, Jiao-Yang Wang, Xiang Dai, Hai-Su Gao, Shu-Yang Zhong, Shi-Yun Che, Xiao-Yu Zuo, Jing-Hua Liu, Yun-Hua Liu, Xing-Chao Fan, Hai-Ning Chen, Wei-Yue Wang, Zi-Ran Yin, Xian-Yu Bai, Jie Zhang, Yan-Qi Jiang, Yan Gong, Yi Chen, Zhi-Yu |
author_sort | Ge, Ming-Yang |
collection | PubMed |
description | BACKGROUND & AIMS: Tumor-associated chronic inflammation has been determined to play a crucial role in tumor progression, angiogenesis and immunosuppression. The objective of this study was to assess the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in perihilar cholangiocarcinoma (pCCA) patients following curative resection. METHODS: Consecutive pCCA patients following curative resection at 3 Chinese hospitals between 2014 and 2018 were included. The NLR was defined as the ratio of neutrophil count to lymphocyte count. PLR was defined as the ratio of platelet count to lymphocyte count. The optimal cutoff values of preoperative NLR and PLR were determined according to receiver operating characteristic (ROC) curves for the prediction of 1-year overall survival (OS), and all patients were divided into high- and low-risk groups. Kaplan-Meier curves and Cox regression models were used to investigate the relationship between values of NLR and PLR and values of OS and recurrence-free survival (RFS) in pCCA patients. The usefulness of NLR and PLR in predicting OS and RFS was evaluated by time-dependent ROC curves. RESULTS: A total of 333 patients were included. According to the ROC curve for the prediction of 1-year OS, the optimal cutoff values of preoperative NLR and PLR were 1.68 and 113.1, respectively, and all patients were divided into high- and low-risk groups. The 5-year survival rates in the low-NLR (<1.68) and low-PLR groups (<113.1) were 30.1% and 29.4%, respectively, which were significantly higher than the rates of 14.9% and 3.3% in the high-NLR group (≥1.68) and high-PLR group (≥113.1), respectively. In multivariate analysis, high NLR and high PLR were independently associated with poor OS and RFS for pCCA patients. The time-dependent ROC curve revealed that both NLR and PLR were ideally useful in predicting OS and RFS for pCCA patients. CONCLUSIONS: This study found that both NLR and PLR could be used to effectively predict long-term survival in patients with pCCA who underwent curative resection. |
format | Online Article Text |
id | pubmed-9845724 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98457242023-01-19 Assessment of the prognostic value of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in perihilar cholangiocarcinoma patients following curative resection: A multicenter study of 333 patients Ge, Ming-Yang Liu, Zhi-Peng Pan, Yu Wang, Jiao-Yang Wang, Xiang Dai, Hai-Su Gao, Shu-Yang Zhong, Shi-Yun Che, Xiao-Yu Zuo, Jing-Hua Liu, Yun-Hua Liu, Xing-Chao Fan, Hai-Ning Chen, Wei-Yue Wang, Zi-Ran Yin, Xian-Yu Bai, Jie Zhang, Yan-Qi Jiang, Yan Gong, Yi Chen, Zhi-Yu Front Oncol Oncology BACKGROUND & AIMS: Tumor-associated chronic inflammation has been determined to play a crucial role in tumor progression, angiogenesis and immunosuppression. The objective of this study was to assess the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in perihilar cholangiocarcinoma (pCCA) patients following curative resection. METHODS: Consecutive pCCA patients following curative resection at 3 Chinese hospitals between 2014 and 2018 were included. The NLR was defined as the ratio of neutrophil count to lymphocyte count. PLR was defined as the ratio of platelet count to lymphocyte count. The optimal cutoff values of preoperative NLR and PLR were determined according to receiver operating characteristic (ROC) curves for the prediction of 1-year overall survival (OS), and all patients were divided into high- and low-risk groups. Kaplan-Meier curves and Cox regression models were used to investigate the relationship between values of NLR and PLR and values of OS and recurrence-free survival (RFS) in pCCA patients. The usefulness of NLR and PLR in predicting OS and RFS was evaluated by time-dependent ROC curves. RESULTS: A total of 333 patients were included. According to the ROC curve for the prediction of 1-year OS, the optimal cutoff values of preoperative NLR and PLR were 1.68 and 113.1, respectively, and all patients were divided into high- and low-risk groups. The 5-year survival rates in the low-NLR (<1.68) and low-PLR groups (<113.1) were 30.1% and 29.4%, respectively, which were significantly higher than the rates of 14.9% and 3.3% in the high-NLR group (≥1.68) and high-PLR group (≥113.1), respectively. In multivariate analysis, high NLR and high PLR were independently associated with poor OS and RFS for pCCA patients. The time-dependent ROC curve revealed that both NLR and PLR were ideally useful in predicting OS and RFS for pCCA patients. CONCLUSIONS: This study found that both NLR and PLR could be used to effectively predict long-term survival in patients with pCCA who underwent curative resection. Frontiers Media S.A. 2023-01-04 /pmc/articles/PMC9845724/ /pubmed/36686802 http://dx.doi.org/10.3389/fonc.2022.1104810 Text en Copyright © 2023 Ge, Liu, Pan, Wang, Wang, Dai, Gao, Zhong, Che, Zuo, Liu, Liu, Fan, Chen, Wang, Yin, Bai, Zhang, Jiang, Gong and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Ge, Ming-Yang Liu, Zhi-Peng Pan, Yu Wang, Jiao-Yang Wang, Xiang Dai, Hai-Su Gao, Shu-Yang Zhong, Shi-Yun Che, Xiao-Yu Zuo, Jing-Hua Liu, Yun-Hua Liu, Xing-Chao Fan, Hai-Ning Chen, Wei-Yue Wang, Zi-Ran Yin, Xian-Yu Bai, Jie Zhang, Yan-Qi Jiang, Yan Gong, Yi Chen, Zhi-Yu Assessment of the prognostic value of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in perihilar cholangiocarcinoma patients following curative resection: A multicenter study of 333 patients |
title | Assessment of the prognostic value of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in perihilar cholangiocarcinoma patients following curative resection: A multicenter study of 333 patients
|
title_full | Assessment of the prognostic value of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in perihilar cholangiocarcinoma patients following curative resection: A multicenter study of 333 patients
|
title_fullStr | Assessment of the prognostic value of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in perihilar cholangiocarcinoma patients following curative resection: A multicenter study of 333 patients
|
title_full_unstemmed | Assessment of the prognostic value of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in perihilar cholangiocarcinoma patients following curative resection: A multicenter study of 333 patients
|
title_short | Assessment of the prognostic value of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in perihilar cholangiocarcinoma patients following curative resection: A multicenter study of 333 patients
|
title_sort | assessment of the prognostic value of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in perihilar cholangiocarcinoma patients following curative resection: a multicenter study of 333 patients |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845724/ https://www.ncbi.nlm.nih.gov/pubmed/36686802 http://dx.doi.org/10.3389/fonc.2022.1104810 |
work_keys_str_mv | AT gemingyang assessmentoftheprognosticvalueoftheneutrophiltolymphocyteratioandplatelettolymphocyteratioinperihilarcholangiocarcinomapatientsfollowingcurativeresectionamulticenterstudyof333patients AT liuzhipeng assessmentoftheprognosticvalueoftheneutrophiltolymphocyteratioandplatelettolymphocyteratioinperihilarcholangiocarcinomapatientsfollowingcurativeresectionamulticenterstudyof333patients AT panyu assessmentoftheprognosticvalueoftheneutrophiltolymphocyteratioandplatelettolymphocyteratioinperihilarcholangiocarcinomapatientsfollowingcurativeresectionamulticenterstudyof333patients AT wangjiaoyang assessmentoftheprognosticvalueoftheneutrophiltolymphocyteratioandplatelettolymphocyteratioinperihilarcholangiocarcinomapatientsfollowingcurativeresectionamulticenterstudyof333patients AT wangxiang assessmentoftheprognosticvalueoftheneutrophiltolymphocyteratioandplatelettolymphocyteratioinperihilarcholangiocarcinomapatientsfollowingcurativeresectionamulticenterstudyof333patients AT daihaisu assessmentoftheprognosticvalueoftheneutrophiltolymphocyteratioandplatelettolymphocyteratioinperihilarcholangiocarcinomapatientsfollowingcurativeresectionamulticenterstudyof333patients AT gaoshuyang assessmentoftheprognosticvalueoftheneutrophiltolymphocyteratioandplatelettolymphocyteratioinperihilarcholangiocarcinomapatientsfollowingcurativeresectionamulticenterstudyof333patients AT zhongshiyun assessmentoftheprognosticvalueoftheneutrophiltolymphocyteratioandplatelettolymphocyteratioinperihilarcholangiocarcinomapatientsfollowingcurativeresectionamulticenterstudyof333patients AT chexiaoyu assessmentoftheprognosticvalueoftheneutrophiltolymphocyteratioandplatelettolymphocyteratioinperihilarcholangiocarcinomapatientsfollowingcurativeresectionamulticenterstudyof333patients AT zuojinghua assessmentoftheprognosticvalueoftheneutrophiltolymphocyteratioandplatelettolymphocyteratioinperihilarcholangiocarcinomapatientsfollowingcurativeresectionamulticenterstudyof333patients AT liuyunhua assessmentoftheprognosticvalueoftheneutrophiltolymphocyteratioandplatelettolymphocyteratioinperihilarcholangiocarcinomapatientsfollowingcurativeresectionamulticenterstudyof333patients AT liuxingchao assessmentoftheprognosticvalueoftheneutrophiltolymphocyteratioandplatelettolymphocyteratioinperihilarcholangiocarcinomapatientsfollowingcurativeresectionamulticenterstudyof333patients AT fanhaining assessmentoftheprognosticvalueoftheneutrophiltolymphocyteratioandplatelettolymphocyteratioinperihilarcholangiocarcinomapatientsfollowingcurativeresectionamulticenterstudyof333patients AT chenweiyue assessmentoftheprognosticvalueoftheneutrophiltolymphocyteratioandplatelettolymphocyteratioinperihilarcholangiocarcinomapatientsfollowingcurativeresectionamulticenterstudyof333patients AT wangziran assessmentoftheprognosticvalueoftheneutrophiltolymphocyteratioandplatelettolymphocyteratioinperihilarcholangiocarcinomapatientsfollowingcurativeresectionamulticenterstudyof333patients AT yinxianyu assessmentoftheprognosticvalueoftheneutrophiltolymphocyteratioandplatelettolymphocyteratioinperihilarcholangiocarcinomapatientsfollowingcurativeresectionamulticenterstudyof333patients AT baijie assessmentoftheprognosticvalueoftheneutrophiltolymphocyteratioandplatelettolymphocyteratioinperihilarcholangiocarcinomapatientsfollowingcurativeresectionamulticenterstudyof333patients AT zhangyanqi assessmentoftheprognosticvalueoftheneutrophiltolymphocyteratioandplatelettolymphocyteratioinperihilarcholangiocarcinomapatientsfollowingcurativeresectionamulticenterstudyof333patients AT jiangyan assessmentoftheprognosticvalueoftheneutrophiltolymphocyteratioandplatelettolymphocyteratioinperihilarcholangiocarcinomapatientsfollowingcurativeresectionamulticenterstudyof333patients AT gongyi assessmentoftheprognosticvalueoftheneutrophiltolymphocyteratioandplatelettolymphocyteratioinperihilarcholangiocarcinomapatientsfollowingcurativeresectionamulticenterstudyof333patients AT chenzhiyu assessmentoftheprognosticvalueoftheneutrophiltolymphocyteratioandplatelettolymphocyteratioinperihilarcholangiocarcinomapatientsfollowingcurativeresectionamulticenterstudyof333patients |