Synthesis of Bis(3‐indolyl)methanes Mediated by Potassium tert‐Butoxide

The indole moiety is an important N‐heterocycle found in natural products, and a key structural component of many value‐added chemicals including pharmaceuticals. In particular, bis(3‐indolyl)methanes (BIMs) are an important subgroup of indoles, composed of two indole units. Herein, we report the de...

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Detalles Bibliográficos
Autores principales: Santos, A. Sofia, Ferro, Rita D., Viduedo, Nuno, Maia, Luísa B., Silva, Artur M. S., Marques, M. Manuel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845755/
https://www.ncbi.nlm.nih.gov/pubmed/36650736
http://dx.doi.org/10.1002/open.202200265
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author Santos, A. Sofia
Ferro, Rita D.
Viduedo, Nuno
Maia, Luísa B.
Silva, Artur M. S.
Marques, M. Manuel B.
author_facet Santos, A. Sofia
Ferro, Rita D.
Viduedo, Nuno
Maia, Luísa B.
Silva, Artur M. S.
Marques, M. Manuel B.
author_sort Santos, A. Sofia
collection PubMed
description The indole moiety is an important N‐heterocycle found in natural products, and a key structural component of many value‐added chemicals including pharmaceuticals. In particular, bis(3‐indolyl)methanes (BIMs) are an important subgroup of indoles, composed of two indole units. Herein, we report the development of a simple method to access BIMs derivatives in yields of up to 77 % by exploiting a tBuOK‐mediated coupling reaction of indoles and benzyl alcohols.
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spelling pubmed-98457552023-01-24 Synthesis of Bis(3‐indolyl)methanes Mediated by Potassium tert‐Butoxide Santos, A. Sofia Ferro, Rita D. Viduedo, Nuno Maia, Luísa B. Silva, Artur M. S. Marques, M. Manuel B. ChemistryOpen Research Articles The indole moiety is an important N‐heterocycle found in natural products, and a key structural component of many value‐added chemicals including pharmaceuticals. In particular, bis(3‐indolyl)methanes (BIMs) are an important subgroup of indoles, composed of two indole units. Herein, we report the development of a simple method to access BIMs derivatives in yields of up to 77 % by exploiting a tBuOK‐mediated coupling reaction of indoles and benzyl alcohols. John Wiley and Sons Inc. 2023-01-17 /pmc/articles/PMC9845755/ /pubmed/36650736 http://dx.doi.org/10.1002/open.202200265 Text en © 2023 The Authors. Published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Santos, A. Sofia
Ferro, Rita D.
Viduedo, Nuno
Maia, Luísa B.
Silva, Artur M. S.
Marques, M. Manuel B.
Synthesis of Bis(3‐indolyl)methanes Mediated by Potassium tert‐Butoxide
title Synthesis of Bis(3‐indolyl)methanes Mediated by Potassium tert‐Butoxide
title_full Synthesis of Bis(3‐indolyl)methanes Mediated by Potassium tert‐Butoxide
title_fullStr Synthesis of Bis(3‐indolyl)methanes Mediated by Potassium tert‐Butoxide
title_full_unstemmed Synthesis of Bis(3‐indolyl)methanes Mediated by Potassium tert‐Butoxide
title_short Synthesis of Bis(3‐indolyl)methanes Mediated by Potassium tert‐Butoxide
title_sort synthesis of bis(3‐indolyl)methanes mediated by potassium tert‐butoxide
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845755/
https://www.ncbi.nlm.nih.gov/pubmed/36650736
http://dx.doi.org/10.1002/open.202200265
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