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The potential interaction between medical treatment and radioiodine treatment success: A systematic review
INTRODUCTION: Radioactive iodine (RAI) therapy is a critical component in the post-surgical management of thyroid cancer patients, as well as being a central therapeutic option in the treatment of hyperthyroidism. Previous work suggests that antithyroid drugs hinder the efficacy of RAI therapy in pa...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845773/ https://www.ncbi.nlm.nih.gov/pubmed/36686426 http://dx.doi.org/10.3389/fendo.2022.1061555 |
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author | Zannat, Riazul Lee, Jonathan Muzaffar, Jameel Read, Martin L. Brookes, Katie Sharma, Neil Boelaert, Kristien McCabe, Christopher J. Nieto, Hannah R. |
author_facet | Zannat, Riazul Lee, Jonathan Muzaffar, Jameel Read, Martin L. Brookes, Katie Sharma, Neil Boelaert, Kristien McCabe, Christopher J. Nieto, Hannah R. |
author_sort | Zannat, Riazul |
collection | PubMed |
description | INTRODUCTION: Radioactive iodine (RAI) therapy is a critical component in the post-surgical management of thyroid cancer patients, as well as being a central therapeutic option in the treatment of hyperthyroidism. Previous work suggests that antithyroid drugs hinder the efficacy of RAI therapy in patients. However, the effects of other background medications on RAI treatment efficacy have not been evaluated. Therefore, we performed a systematic review and meta-analysis investigating the potential off-target effects of medication on RAI therapy in patients with thyroid cancer and hyperthyroidism. METHODS: Systematic review and meta-analysis according to the 2020 PRISMA guidelines. Databases searched: MEDLINE, EMBASE and Cochrane Library for studies published between 2001 and 2021. RESULTS: Sixty-nine unique studies were identified. After screening, 17 studies with 3313 participants were included. One study investigated thyroid cancer, with the rest targeted to hyperthyroidism. The majority of studies evaluated the effects of antithyroid drugs; the other drugs studied included lithium, prednisone and glycididazole sodium. Antithyroid drugs were associated with negative impacts on post-RAI outcomes (n = 5 studies, RR = 0.81, p = 0.02). However, meta-analysis found moderate heterogeneity between studies (I2 = 51%, τ2 = 0.0199, p = 0.08). Interestingly, lithium (n = 3 studies), prednisone (n = 1 study) and glycididazole (n = 1 study) appeared to have positive impacts on post-RAI outcomes upon qualitative analysis. CONCLUSION: Our systematic review strengthens previous work on antithyroid medication effects on RAI, and highlights that this field remains under researched especially for background medications unrelated to thyroid disease, with very few papers on non-thyroid medications published. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/display_record.php, identifier CRD42021274026. |
format | Online Article Text |
id | pubmed-9845773 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98457732023-01-19 The potential interaction between medical treatment and radioiodine treatment success: A systematic review Zannat, Riazul Lee, Jonathan Muzaffar, Jameel Read, Martin L. Brookes, Katie Sharma, Neil Boelaert, Kristien McCabe, Christopher J. Nieto, Hannah R. Front Endocrinol (Lausanne) Endocrinology INTRODUCTION: Radioactive iodine (RAI) therapy is a critical component in the post-surgical management of thyroid cancer patients, as well as being a central therapeutic option in the treatment of hyperthyroidism. Previous work suggests that antithyroid drugs hinder the efficacy of RAI therapy in patients. However, the effects of other background medications on RAI treatment efficacy have not been evaluated. Therefore, we performed a systematic review and meta-analysis investigating the potential off-target effects of medication on RAI therapy in patients with thyroid cancer and hyperthyroidism. METHODS: Systematic review and meta-analysis according to the 2020 PRISMA guidelines. Databases searched: MEDLINE, EMBASE and Cochrane Library for studies published between 2001 and 2021. RESULTS: Sixty-nine unique studies were identified. After screening, 17 studies with 3313 participants were included. One study investigated thyroid cancer, with the rest targeted to hyperthyroidism. The majority of studies evaluated the effects of antithyroid drugs; the other drugs studied included lithium, prednisone and glycididazole sodium. Antithyroid drugs were associated with negative impacts on post-RAI outcomes (n = 5 studies, RR = 0.81, p = 0.02). However, meta-analysis found moderate heterogeneity between studies (I2 = 51%, τ2 = 0.0199, p = 0.08). Interestingly, lithium (n = 3 studies), prednisone (n = 1 study) and glycididazole (n = 1 study) appeared to have positive impacts on post-RAI outcomes upon qualitative analysis. CONCLUSION: Our systematic review strengthens previous work on antithyroid medication effects on RAI, and highlights that this field remains under researched especially for background medications unrelated to thyroid disease, with very few papers on non-thyroid medications published. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/display_record.php, identifier CRD42021274026. Frontiers Media S.A. 2023-01-04 /pmc/articles/PMC9845773/ /pubmed/36686426 http://dx.doi.org/10.3389/fendo.2022.1061555 Text en Copyright © 2023 Zannat, Lee, Muzaffar, Read, Brookes, Sharma, Boelaert, McCabe and Nieto https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Zannat, Riazul Lee, Jonathan Muzaffar, Jameel Read, Martin L. Brookes, Katie Sharma, Neil Boelaert, Kristien McCabe, Christopher J. Nieto, Hannah R. The potential interaction between medical treatment and radioiodine treatment success: A systematic review |
title | The potential interaction between medical treatment and radioiodine treatment success: A systematic review |
title_full | The potential interaction between medical treatment and radioiodine treatment success: A systematic review |
title_fullStr | The potential interaction between medical treatment and radioiodine treatment success: A systematic review |
title_full_unstemmed | The potential interaction between medical treatment and radioiodine treatment success: A systematic review |
title_short | The potential interaction between medical treatment and radioiodine treatment success: A systematic review |
title_sort | potential interaction between medical treatment and radioiodine treatment success: a systematic review |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845773/ https://www.ncbi.nlm.nih.gov/pubmed/36686426 http://dx.doi.org/10.3389/fendo.2022.1061555 |
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