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Separation, purification, and crystallization of 1,5-pentanediamine hydrochloride from fermentation broth by cation resin
1,5-Pentanediamine hydrochloride (PDAH) was an important raw material for the preparation of bio-based pentamethylene diisocyanate (PDI). PDI has shown excellent properties in the application of adhesives and thermosetting polyurethane. In this study, PDAH was recovered from 1,5-pentanediamine (PDA)...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845778/ https://www.ncbi.nlm.nih.gov/pubmed/36686243 http://dx.doi.org/10.3389/fbioe.2022.1104041 |
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author | Li, Hui Chen, Xu Tang, Yibo Yang, Yue He, Feng Wang, Xin Li, Ganlu Chen, Kequan Ouyang, Pingkai Yang, Yuning |
author_facet | Li, Hui Chen, Xu Tang, Yibo Yang, Yue He, Feng Wang, Xin Li, Ganlu Chen, Kequan Ouyang, Pingkai Yang, Yuning |
author_sort | Li, Hui |
collection | PubMed |
description | 1,5-Pentanediamine hydrochloride (PDAH) was an important raw material for the preparation of bio-based pentamethylene diisocyanate (PDI). PDI has shown excellent properties in the application of adhesives and thermosetting polyurethane. In this study, PDAH was recovered from 1,5-pentanediamine (PDA) fermentation broth using a cation exchange resin and purified by crystallization. D152 was selected as the most suitable resin for purifying PDAH. The effects of solution pH, initial temperature, concentration of PDA, and adsorption time were studied by the static adsorption method. The equilibrium adsorption data were well fitted to Langmiur, Freundlich, and Temkin-Pyzhev adsorption isotherms. The adsorption free energy, enthalpy, and entropy were calculated. The experimental data were well described by the pseudo first-order kinetics model. The dynamic experiment in the fixed bed column showed that under optimal conditions, the adsorption capacity reached 96.45 mg g(−1), and the recovery proportion of the effective section reached 80.16%. In addition, the crystallization of the PDAH solution obtained by elution proved that the crystal product quality of resin eluting solution was highest. Thus, our research will contribute to the industrial scale-up of the separation of PDAH. |
format | Online Article Text |
id | pubmed-9845778 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98457782023-01-19 Separation, purification, and crystallization of 1,5-pentanediamine hydrochloride from fermentation broth by cation resin Li, Hui Chen, Xu Tang, Yibo Yang, Yue He, Feng Wang, Xin Li, Ganlu Chen, Kequan Ouyang, Pingkai Yang, Yuning Front Bioeng Biotechnol Bioengineering and Biotechnology 1,5-Pentanediamine hydrochloride (PDAH) was an important raw material for the preparation of bio-based pentamethylene diisocyanate (PDI). PDI has shown excellent properties in the application of adhesives and thermosetting polyurethane. In this study, PDAH was recovered from 1,5-pentanediamine (PDA) fermentation broth using a cation exchange resin and purified by crystallization. D152 was selected as the most suitable resin for purifying PDAH. The effects of solution pH, initial temperature, concentration of PDA, and adsorption time were studied by the static adsorption method. The equilibrium adsorption data were well fitted to Langmiur, Freundlich, and Temkin-Pyzhev adsorption isotherms. The adsorption free energy, enthalpy, and entropy were calculated. The experimental data were well described by the pseudo first-order kinetics model. The dynamic experiment in the fixed bed column showed that under optimal conditions, the adsorption capacity reached 96.45 mg g(−1), and the recovery proportion of the effective section reached 80.16%. In addition, the crystallization of the PDAH solution obtained by elution proved that the crystal product quality of resin eluting solution was highest. Thus, our research will contribute to the industrial scale-up of the separation of PDAH. Frontiers Media S.A. 2023-01-04 /pmc/articles/PMC9845778/ /pubmed/36686243 http://dx.doi.org/10.3389/fbioe.2022.1104041 Text en Copyright © 2023 Li, Chen, Tang, Yang, He, Wang, Li, Chen, Ouyang and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Li, Hui Chen, Xu Tang, Yibo Yang, Yue He, Feng Wang, Xin Li, Ganlu Chen, Kequan Ouyang, Pingkai Yang, Yuning Separation, purification, and crystallization of 1,5-pentanediamine hydrochloride from fermentation broth by cation resin |
title | Separation, purification, and crystallization of 1,5-pentanediamine hydrochloride from fermentation broth by cation resin |
title_full | Separation, purification, and crystallization of 1,5-pentanediamine hydrochloride from fermentation broth by cation resin |
title_fullStr | Separation, purification, and crystallization of 1,5-pentanediamine hydrochloride from fermentation broth by cation resin |
title_full_unstemmed | Separation, purification, and crystallization of 1,5-pentanediamine hydrochloride from fermentation broth by cation resin |
title_short | Separation, purification, and crystallization of 1,5-pentanediamine hydrochloride from fermentation broth by cation resin |
title_sort | separation, purification, and crystallization of 1,5-pentanediamine hydrochloride from fermentation broth by cation resin |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845778/ https://www.ncbi.nlm.nih.gov/pubmed/36686243 http://dx.doi.org/10.3389/fbioe.2022.1104041 |
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