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Compromised osteogenic effect of exosomes internalized by senescent bone marrow stem cells via endocytoses involving clathrin, macropinocytosis and caveolae

Stem cell senescence leads to progressive functional declines and disrupts the physiological homeostasis of bone environment. Stem cell-derived exosomes are emerging as promising therapeutical approaches to treat diverse aging-related osseous diseases. Herein, a previously reported osteoinductive ex...

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Detalles Bibliográficos
Autores principales: Qi, Lei, Ge, Weiwen, Pan, Cancan, Jiang, Weidong, Lin, Dan, Zhang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846034/
https://www.ncbi.nlm.nih.gov/pubmed/36686252
http://dx.doi.org/10.3389/fbioe.2022.1090914