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Targeting the pathological network: Feasibility of network-based optimization of transcranial magnetic stimulation coil placement for treatment of psychiatric disorders

It has been recognized that the efficacy of TMS-based modulation may depend on the network profile of the stimulated regions throughout the brain. However, what profile of this stimulation network optimally benefits treatment outcomes is yet to be addressed. The answer to the question is crucial for...

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Autores principales: Cao, Zhengcao, Xiao, Xiang, Zhao, Yang, Jiang, Yihan, Xie, Cong, Paillère-Martinot, Marie-Laure, Artiges, Eric, Li, Zheng, Daskalakis, Zafiris J., Yang, Yihong, Zhu, Chaozhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846047/
https://www.ncbi.nlm.nih.gov/pubmed/36685239
http://dx.doi.org/10.3389/fnins.2022.1079078
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author Cao, Zhengcao
Xiao, Xiang
Zhao, Yang
Jiang, Yihan
Xie, Cong
Paillère-Martinot, Marie-Laure
Artiges, Eric
Li, Zheng
Daskalakis, Zafiris J.
Yang, Yihong
Zhu, Chaozhe
author_facet Cao, Zhengcao
Xiao, Xiang
Zhao, Yang
Jiang, Yihan
Xie, Cong
Paillère-Martinot, Marie-Laure
Artiges, Eric
Li, Zheng
Daskalakis, Zafiris J.
Yang, Yihong
Zhu, Chaozhe
author_sort Cao, Zhengcao
collection PubMed
description It has been recognized that the efficacy of TMS-based modulation may depend on the network profile of the stimulated regions throughout the brain. However, what profile of this stimulation network optimally benefits treatment outcomes is yet to be addressed. The answer to the question is crucial for informing network-based optimization of stimulation parameters, such as coil placement, in TMS treatments. In this study, we aimed to investigate the feasibility of taking a disease-specific network as the target of stimulation network for guiding individualized coil placement in TMS treatments. We present here a novel network-based model for TMS targeting of the pathological network. First, combining E-field modeling and resting-state functional connectivity, stimulation networks were modeled from locations and orientations of the TMS coil. Second, the spatial anti-correlation between the stimulation network and the pathological network of a given disease was hypothesized to predict the treatment outcome. The proposed model was validated to predict treatment efficacy from the position and orientation of TMS coils in two depression cohorts and one schizophrenia cohort with auditory verbal hallucinations. We further demonstrate the utility of the proposed model in guiding individualized TMS treatment for psychiatric disorders. In this proof-of-concept study, we demonstrated the feasibility of the novel network-based targeting strategy that uses the whole-brain, system-level abnormity of a specific psychiatric disease as a target. Results based on empirical data suggest that the strategy may potentially be utilized to identify individualized coil parameters for maximal therapeutic effects.
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spelling pubmed-98460472023-01-19 Targeting the pathological network: Feasibility of network-based optimization of transcranial magnetic stimulation coil placement for treatment of psychiatric disorders Cao, Zhengcao Xiao, Xiang Zhao, Yang Jiang, Yihan Xie, Cong Paillère-Martinot, Marie-Laure Artiges, Eric Li, Zheng Daskalakis, Zafiris J. Yang, Yihong Zhu, Chaozhe Front Neurosci Neuroscience It has been recognized that the efficacy of TMS-based modulation may depend on the network profile of the stimulated regions throughout the brain. However, what profile of this stimulation network optimally benefits treatment outcomes is yet to be addressed. The answer to the question is crucial for informing network-based optimization of stimulation parameters, such as coil placement, in TMS treatments. In this study, we aimed to investigate the feasibility of taking a disease-specific network as the target of stimulation network for guiding individualized coil placement in TMS treatments. We present here a novel network-based model for TMS targeting of the pathological network. First, combining E-field modeling and resting-state functional connectivity, stimulation networks were modeled from locations and orientations of the TMS coil. Second, the spatial anti-correlation between the stimulation network and the pathological network of a given disease was hypothesized to predict the treatment outcome. The proposed model was validated to predict treatment efficacy from the position and orientation of TMS coils in two depression cohorts and one schizophrenia cohort with auditory verbal hallucinations. We further demonstrate the utility of the proposed model in guiding individualized TMS treatment for psychiatric disorders. In this proof-of-concept study, we demonstrated the feasibility of the novel network-based targeting strategy that uses the whole-brain, system-level abnormity of a specific psychiatric disease as a target. Results based on empirical data suggest that the strategy may potentially be utilized to identify individualized coil parameters for maximal therapeutic effects. Frontiers Media S.A. 2023-01-04 /pmc/articles/PMC9846047/ /pubmed/36685239 http://dx.doi.org/10.3389/fnins.2022.1079078 Text en Copyright © 2023 Cao, Xiao, Zhao, Jiang, Xie, Paillère-Martinot, Artiges, Li, Daskalakis, Yang and Zhu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Cao, Zhengcao
Xiao, Xiang
Zhao, Yang
Jiang, Yihan
Xie, Cong
Paillère-Martinot, Marie-Laure
Artiges, Eric
Li, Zheng
Daskalakis, Zafiris J.
Yang, Yihong
Zhu, Chaozhe
Targeting the pathological network: Feasibility of network-based optimization of transcranial magnetic stimulation coil placement for treatment of psychiatric disorders
title Targeting the pathological network: Feasibility of network-based optimization of transcranial magnetic stimulation coil placement for treatment of psychiatric disorders
title_full Targeting the pathological network: Feasibility of network-based optimization of transcranial magnetic stimulation coil placement for treatment of psychiatric disorders
title_fullStr Targeting the pathological network: Feasibility of network-based optimization of transcranial magnetic stimulation coil placement for treatment of psychiatric disorders
title_full_unstemmed Targeting the pathological network: Feasibility of network-based optimization of transcranial magnetic stimulation coil placement for treatment of psychiatric disorders
title_short Targeting the pathological network: Feasibility of network-based optimization of transcranial magnetic stimulation coil placement for treatment of psychiatric disorders
title_sort targeting the pathological network: feasibility of network-based optimization of transcranial magnetic stimulation coil placement for treatment of psychiatric disorders
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846047/
https://www.ncbi.nlm.nih.gov/pubmed/36685239
http://dx.doi.org/10.3389/fnins.2022.1079078
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