Biological characteristics of γδT cells and application in tumor immunotherapy

Human γδT cells are a special immune cell type which exist in small quantities in the body, do not require processing and presentation for antigen recognition, and have non-major histocompatibility complex (MHC)-restricted immune response. They play an important role in the body’s anti-tumor, anti-i...

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Detalles Bibliográficos
Autores principales: Zhu, Renhong, Yan, Qian, Wang, Yashu, Wang, Keqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846053/
https://www.ncbi.nlm.nih.gov/pubmed/36685942
http://dx.doi.org/10.3389/fgene.2022.1077419
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author Zhu, Renhong
Yan, Qian
Wang, Yashu
Wang, Keqiang
author_facet Zhu, Renhong
Yan, Qian
Wang, Yashu
Wang, Keqiang
author_sort Zhu, Renhong
collection PubMed
description Human γδT cells are a special immune cell type which exist in small quantities in the body, do not require processing and presentation for antigen recognition, and have non-major histocompatibility complex (MHC)-restricted immune response. They play an important role in the body’s anti-tumor, anti-infection, immune regulation, immune surveillance and maintenance of immune tolerance. This article reviews the generation and development of human γδT cells, genetic characteristics, classification, recognition and role of antigens, and research progress in tumor immunotherapy.
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spelling pubmed-98460532023-01-19 Biological characteristics of γδT cells and application in tumor immunotherapy Zhu, Renhong Yan, Qian Wang, Yashu Wang, Keqiang Front Genet Genetics Human γδT cells are a special immune cell type which exist in small quantities in the body, do not require processing and presentation for antigen recognition, and have non-major histocompatibility complex (MHC)-restricted immune response. They play an important role in the body’s anti-tumor, anti-infection, immune regulation, immune surveillance and maintenance of immune tolerance. This article reviews the generation and development of human γδT cells, genetic characteristics, classification, recognition and role of antigens, and research progress in tumor immunotherapy. Frontiers Media S.A. 2023-01-04 /pmc/articles/PMC9846053/ /pubmed/36685942 http://dx.doi.org/10.3389/fgene.2022.1077419 Text en Copyright © 2023 Zhu, Yan, Wang and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Zhu, Renhong
Yan, Qian
Wang, Yashu
Wang, Keqiang
Biological characteristics of γδT cells and application in tumor immunotherapy
title Biological characteristics of γδT cells and application in tumor immunotherapy
title_full Biological characteristics of γδT cells and application in tumor immunotherapy
title_fullStr Biological characteristics of γδT cells and application in tumor immunotherapy
title_full_unstemmed Biological characteristics of γδT cells and application in tumor immunotherapy
title_short Biological characteristics of γδT cells and application in tumor immunotherapy
title_sort biological characteristics of γδt cells and application in tumor immunotherapy
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846053/
https://www.ncbi.nlm.nih.gov/pubmed/36685942
http://dx.doi.org/10.3389/fgene.2022.1077419
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