Cargando…

YIV-906 enhances nuclear factor of activated T-cells (NFAT) activity of T cells and promotes immune checkpoint blockade antibody action and CAR T-cell activity

YIV-906 is a systems biology botanical cancer drug, inspired by a traditional Chinese herbal formulation. Results from eight Phase I/II to II clinical studies demonstrated the potential of YIV-906 to prolong survival and improve the quality of life of cancer patients. As an immunomodulator in the tu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lam, Wing, Hu, Rong, Liu, Shwu-Huey, Cheng, Peikwen, Cheng, Yung-Chi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846171/ https://www.ncbi.nlm.nih.gov/pubmed/36686648 http://dx.doi.org/10.3389/fphar.2022.1095186

Ejemplares similares

Mechanism Based Quality Control (MBQC) of Herbal Products: A Case Study YIV-906 (PHY906)
por: Lam, Wing, et al.
Publicado: (2018)

YIV-906 potentiated anti-PD1 action against hepatocellular carcinoma by enhancing adaptive and innate immunity in the tumor microenvironment
por: Yang, Xiaochen, et al.
Publicado: (2021)

YIV-818-A: a novel therapeutic agent in prostate cancer management through androgen receptor downregulation, glucocorticoid receptor inhibition, epigenetic regulation, and enhancement of apalutamide, darolutamide, and enzalutamide efficacy
por: Lam, Wing, et al.
Publicado: (2023)

The number of intestinal bacteria is not critical for the enhancement of antitumor activity and reduction of intestinal toxicity of irinotecan by the Chinese herbal medicine PHY906 (KD018)
por: Lam, Wing, et al.
Publicado: (2014)

PHY906(KD018), an adjuvant based on a 1800-year-old Chinese medicine, enhanced the anti-tumor activity of Sorafenib by changing the tumor microenvironment
por: Lam, Wing, et al.
Publicado: (2015)

A Phase II Clinical Trial on the Combination Therapy of PHY906 Plus Capecitabine in Hepatocellular Carcinoma
por: Changou, Chun A., et al.
Publicado: (2020)

Nuclear factor of activated T cells (NFAT) signaling regulates PTEN expression and intestinal cell differentiation
por: Wang, Qingding, et al.
Publicado: (2011)

Coupled feedback regulation of nuclear factor of activated T-cells (NFAT) modulates activation-induced cell death of T cells
por: Shin, Sung-Young, et al.
Publicado: (2019)

Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies
por: Wang, Hao, et al.
Publicado: (2019)

Calcineurin-nuclear factor for activated T cells (NFAT) signaling in pathophysiology of wound healing
por: Manabe, Takahiro, et al.
Publicado: (2021)

The antihypertensive felodipine shows synergistic activity with immune checkpoint blockade and inhibits tumor growth via NFAT1 in LUSC
por: Liang, Si-Yu, et al.
Publicado: (2023)

The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis
por: Sant’Anna, Ricardo, et al.
Publicado: (2023)

Inhibition of Nuclear Factor of Activated T-Cells (NFAT) Suppresses Accelerated Atherosclerosis in Diabetic Mice
por: Zetterqvist, Anna V., et al.
Publicado: (2013)

A comprehensive platform for quality control of botanical drugs (PhytomicsQC): a case study of Huangqin Tang (HQT) and PHY906
por: Tilton, Robert, et al.
Publicado: (2010)

Arsenic Trioxide Inhibits the Metastasis of Small Cell Lung Cancer by Blocking Calcineurin-Nuclear Factor of Activated T Cells (NFAT) Signaling
por: Zheng, Jin-Cheng, et al.
Publicado: (2019)

CD40 Cross-Linking Induces Migration of Renal Tumor Cell through Nuclear Factor of Activated T Cells (NFAT) Activation
por: Pontrelli, Paola, et al.
Publicado: (2021)

Incorporation of Immune Checkpoint Blockade into Chimeric Antigen Receptor T Cells (CAR-Ts): Combination or Built-In CAR-T
por: Yoon, Dok Hyun, et al.
Publicado: (2018)

Role of Nuclear Factor of Activated T Cells (NFAT) Pathway in Regulating Autophagy and Inflammation in Retinal Pigment Epithelial Cells
por: Pan, Hsuan-Yeh, et al.
Publicado: (2021)

Aromadendrin Inhibits T Cell Activation via Regulation of Calcium Influx and NFAT Activity
por: Lee, Hyun-Su, et al.
Publicado: (2020)

The Nuclear Factor of Activated T Cells (Nfat) Transcription Factor Nfatp (Nfatc2) Is a Repressor of Chondrogenesis
por: Ranger, Ann M., et al.
Publicado: (2000)

The nuclear factor of activated T cells 5 (NFAT5) contributes to the renal corticomedullary differences in gene expression
por: Chernyakov, Dmitry, et al.
Publicado: (2022)

Oxytocin-Stimulated NFAT Transcriptional Activation in Human Myometrial Cells
por: Pont, Jason N. A., et al.
Publicado: (2012)

Dual effect of lithium on NFAT5 activity in kidney cells
por: Küper, Christoph, et al.
Publicado: (2015)

Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment
por: Wang, Ena, et al.
Publicado: (2011)

A Threshold Model for T-Cell Activation in the Era of Checkpoint Blockade Immunotherapy
por: Guram, Kripa, et al.
Publicado: (2019)

Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice
por: Morancho, Beatriz, et al.
Publicado: (2008)

Activation of phagocytosis by immune checkpoint blockade
por: Li, Chia-Wei, et al.
Publicado: (2018)

ARIH1 activates STING-mediated T-cell activation and sensitizes tumors to immune checkpoint blockade
por: Liu, Xiaolan, et al.
Publicado: (2023)

Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation
por: Alam, Muhammad S., et al.
Publicado: (2018)

Structure-Based Optimization of a Peptidyl Inhibitor against Calcineurin-Nuclear Factor of Activated T Cell (NFAT) Interaction
por: Qian, Ziqing, et al.
Publicado: (2014)

Rationale for Combining Bispecific T Cell Activating Antibodies With Checkpoint Blockade for Cancer Therapy
por: Kobold, Sebastian, et al.
Publicado: (2018)

Impact of checkpoint blockade on cancer vaccine–activated CD8(+) T cell responses
por: Santos, Patricia M., et al.
Publicado: (2020)

Checkpoint inhibitor blockade and epigenetic reprogrammability in CD8(+) T-cell activation and exhaustion
por: Belizário, José, et al.
Publicado: (2020)

Immune-Checkpoint Blockade and Active Immunotherapy for Glioma
por: Ahn, Brian J., et al.
Publicado: (2013)

Interferon-γ blockade in CAR T-cell therapy–associated macrophage activation syndrome/hemophagocytic lymphohistiocytosis
por: Rainone, Michael, et al.
Publicado: (2022)

Inhibition of nuclear factor of activated T cells (NFAT) c3 activation attenuates acute lung injury and pulmonary edema in murine models of sepsis
por: Karpurapu, Manjula, et al.
Publicado: (2018)

Nuclear Factor of Activated T Cells (NFAT)-dependent Transactivation Regulated by the Coactivators p300/CREB-binding Protein (CBP)
por: García-Rodríguez, Carmen, et al.
Publicado: (1998)

Chemotherapy-induced recruitment of myeloid-derived suppressor cells abrogates efficacy of immune checkpoint blockade
por: Kwong, Tsz Tung, et al.
Publicado: (2020)

Neuronal calcium sensor proteins are unable to modulate NFAT activation in mammalian cells
por: Fitzgerald, Daniel J., et al.
Publicado: (2008)

TLR9 activation cooperates with T cell checkpoint blockade to regress poorly immunogenic melanoma
por: Reilley, Matthew J., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_8ahlded2eah2mashvbg0m8e16q