PD-1 Inhibitor for Disseminated Mycobacterium avium Infection in a Person With HIV

We report a case of a person with human immunodeficiency virus with disseminated Mycobacterium avium infection, in whom antiretroviral therapy combined with all drugs of anti–M avium activity failed to clear the pathogen. After PD-1 inhibitor treatment, T-cell exhaustion was reversed and M avium–spe...

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Detalles Bibliográficos
Autores principales: Liu, Li, Song, Zichen, Xun, Jingna, Liu, Danping, Wei, Jianhao, Wang, Zhenyan, Tang, Yang, Sun, Jianjun, Chen, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846183/
https://www.ncbi.nlm.nih.gov/pubmed/36686637
http://dx.doi.org/10.1093/ofid/ofac700
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author Liu, Li
Song, Zichen
Xun, Jingna
Liu, Danping
Wei, Jianhao
Wang, Zhenyan
Tang, Yang
Sun, Jianjun
Chen, Jun
author_facet Liu, Li
Song, Zichen
Xun, Jingna
Liu, Danping
Wei, Jianhao
Wang, Zhenyan
Tang, Yang
Sun, Jianjun
Chen, Jun
author_sort Liu, Li
collection PubMed
description We report a case of a person with human immunodeficiency virus with disseminated Mycobacterium avium infection, in whom antiretroviral therapy combined with all drugs of anti–M avium activity failed to clear the pathogen. After PD-1 inhibitor treatment, T-cell exhaustion was reversed and M avium–specific T-cell response was boosted, together with M avium clearance.
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spelling pubmed-98461832023-01-20 PD-1 Inhibitor for Disseminated Mycobacterium avium Infection in a Person With HIV Liu, Li Song, Zichen Xun, Jingna Liu, Danping Wei, Jianhao Wang, Zhenyan Tang, Yang Sun, Jianjun Chen, Jun Open Forum Infect Dis Brief Report We report a case of a person with human immunodeficiency virus with disseminated Mycobacterium avium infection, in whom antiretroviral therapy combined with all drugs of anti–M avium activity failed to clear the pathogen. After PD-1 inhibitor treatment, T-cell exhaustion was reversed and M avium–specific T-cell response was boosted, together with M avium clearance. Oxford University Press 2022-12-28 /pmc/articles/PMC9846183/ /pubmed/36686637 http://dx.doi.org/10.1093/ofid/ofac700 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Liu, Li
Song, Zichen
Xun, Jingna
Liu, Danping
Wei, Jianhao
Wang, Zhenyan
Tang, Yang
Sun, Jianjun
Chen, Jun
PD-1 Inhibitor for Disseminated Mycobacterium avium Infection in a Person With HIV
title PD-1 Inhibitor for Disseminated Mycobacterium avium Infection in a Person With HIV
title_full PD-1 Inhibitor for Disseminated Mycobacterium avium Infection in a Person With HIV
title_fullStr PD-1 Inhibitor for Disseminated Mycobacterium avium Infection in a Person With HIV
title_full_unstemmed PD-1 Inhibitor for Disseminated Mycobacterium avium Infection in a Person With HIV
title_short PD-1 Inhibitor for Disseminated Mycobacterium avium Infection in a Person With HIV
title_sort pd-1 inhibitor for disseminated mycobacterium avium infection in a person with hiv
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846183/
https://www.ncbi.nlm.nih.gov/pubmed/36686637
http://dx.doi.org/10.1093/ofid/ofac700
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