Cargando…

Live birth rate following frozen-thawed blastocyst transfer is higher in high-grade day 6 blastocysts than in low-grade day 5 blastocysts

BACKGROUND: Day 5 (D5) blastocysts are generally given priority to transfer than day 6 (D6) blastocysts; however, which one should be prioritized to transfer when only low-grade D5 and high-grade D6 blastocysts are available? METHODS: A large retrospective cohort study was carried out to evaluate th...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Wenhao, Zhou, Hanying, Chen, Lijuan, Xue, Xia, Shi, Juanzi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846233/
https://www.ncbi.nlm.nih.gov/pubmed/36686429
http://dx.doi.org/10.3389/fendo.2022.1066757
_version_ 1784871123619414016
author Shi, Wenhao
Zhou, Hanying
Chen, Lijuan
Xue, Xia
Shi, Juanzi
author_facet Shi, Wenhao
Zhou, Hanying
Chen, Lijuan
Xue, Xia
Shi, Juanzi
author_sort Shi, Wenhao
collection PubMed
description BACKGROUND: Day 5 (D5) blastocysts are generally given priority to transfer than day 6 (D6) blastocysts; however, which one should be prioritized to transfer when only low-grade D5 and high-grade D6 blastocysts are available? METHODS: A large retrospective cohort study was carried out to evaluate the live birth rate (LBR) following D5 and D6 blastocysts in single frozen-thawed blastocyst transfer (FBT) during January 2014 and December 2018. A multivariate logistic regression was conducted to evaluate the combined impact of expansion day (D5 and D6) and blastocyst quality (high grade/low grade) on LBR, accounting for the potential confounding factors. The biopsied blastocysts from a consecutive PGT-A case series during February 2013 to December 2021 were analyzed in a supplementary study. RESULTS: The LBR achieved in high-grade D6 blastocyst transfer was significantly higher than that in low-grade D5 blastocyst transfer (50.43% vs. 40.70%, aOR 1.54, 95% CI 1.05–2.26, p = 0.027). There were no significant differences in preterm birth rate, very preterm birth rate, mean live birth weight, and birth weight <1,500 g and >4,000 g between the two cohorts. As for aneuploidy analysis in PGT, there were 54.55% of euploid blastocysts (30/55) among high-grade D6 blastocysts, significantly higher than the 41.39% of euploid blastocysts (565/1,365) among low-grade D5 blastocysts (p < 0.001). CONCLUSIONS: Our data suggest that D6 blastocysts with high morphology grading are preferred than D5 blastocysts with low morphology grading when selecting blastocyst transfer to shorten the time of conception.
format Online
Article
Text
id pubmed-9846233
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-98462332023-01-19 Live birth rate following frozen-thawed blastocyst transfer is higher in high-grade day 6 blastocysts than in low-grade day 5 blastocysts Shi, Wenhao Zhou, Hanying Chen, Lijuan Xue, Xia Shi, Juanzi Front Endocrinol (Lausanne) Endocrinology BACKGROUND: Day 5 (D5) blastocysts are generally given priority to transfer than day 6 (D6) blastocysts; however, which one should be prioritized to transfer when only low-grade D5 and high-grade D6 blastocysts are available? METHODS: A large retrospective cohort study was carried out to evaluate the live birth rate (LBR) following D5 and D6 blastocysts in single frozen-thawed blastocyst transfer (FBT) during January 2014 and December 2018. A multivariate logistic regression was conducted to evaluate the combined impact of expansion day (D5 and D6) and blastocyst quality (high grade/low grade) on LBR, accounting for the potential confounding factors. The biopsied blastocysts from a consecutive PGT-A case series during February 2013 to December 2021 were analyzed in a supplementary study. RESULTS: The LBR achieved in high-grade D6 blastocyst transfer was significantly higher than that in low-grade D5 blastocyst transfer (50.43% vs. 40.70%, aOR 1.54, 95% CI 1.05–2.26, p = 0.027). There were no significant differences in preterm birth rate, very preterm birth rate, mean live birth weight, and birth weight <1,500 g and >4,000 g between the two cohorts. As for aneuploidy analysis in PGT, there were 54.55% of euploid blastocysts (30/55) among high-grade D6 blastocysts, significantly higher than the 41.39% of euploid blastocysts (565/1,365) among low-grade D5 blastocysts (p < 0.001). CONCLUSIONS: Our data suggest that D6 blastocysts with high morphology grading are preferred than D5 blastocysts with low morphology grading when selecting blastocyst transfer to shorten the time of conception. Frontiers Media S.A. 2023-01-04 /pmc/articles/PMC9846233/ /pubmed/36686429 http://dx.doi.org/10.3389/fendo.2022.1066757 Text en Copyright © 2023 Shi, Zhou, Chen, Xue and Shi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Shi, Wenhao
Zhou, Hanying
Chen, Lijuan
Xue, Xia
Shi, Juanzi
Live birth rate following frozen-thawed blastocyst transfer is higher in high-grade day 6 blastocysts than in low-grade day 5 blastocysts
title Live birth rate following frozen-thawed blastocyst transfer is higher in high-grade day 6 blastocysts than in low-grade day 5 blastocysts
title_full Live birth rate following frozen-thawed blastocyst transfer is higher in high-grade day 6 blastocysts than in low-grade day 5 blastocysts
title_fullStr Live birth rate following frozen-thawed blastocyst transfer is higher in high-grade day 6 blastocysts than in low-grade day 5 blastocysts
title_full_unstemmed Live birth rate following frozen-thawed blastocyst transfer is higher in high-grade day 6 blastocysts than in low-grade day 5 blastocysts
title_short Live birth rate following frozen-thawed blastocyst transfer is higher in high-grade day 6 blastocysts than in low-grade day 5 blastocysts
title_sort live birth rate following frozen-thawed blastocyst transfer is higher in high-grade day 6 blastocysts than in low-grade day 5 blastocysts
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846233/
https://www.ncbi.nlm.nih.gov/pubmed/36686429
http://dx.doi.org/10.3389/fendo.2022.1066757
work_keys_str_mv AT shiwenhao livebirthratefollowingfrozenthawedblastocysttransferishigherinhighgradeday6blastocyststhaninlowgradeday5blastocysts
AT zhouhanying livebirthratefollowingfrozenthawedblastocysttransferishigherinhighgradeday6blastocyststhaninlowgradeday5blastocysts
AT chenlijuan livebirthratefollowingfrozenthawedblastocysttransferishigherinhighgradeday6blastocyststhaninlowgradeday5blastocysts
AT xuexia livebirthratefollowingfrozenthawedblastocysttransferishigherinhighgradeday6blastocyststhaninlowgradeday5blastocysts
AT shijuanzi livebirthratefollowingfrozenthawedblastocysttransferishigherinhighgradeday6blastocyststhaninlowgradeday5blastocysts