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Potential role of IGF-1/GLP-1 signaling activation in intracerebral hemorrhage
IGF-1 and GLP-1 receptors are essential in all tissues, facilitating defense by upregulating anabolic processes. They are abundantly distributed throughout the central nervous system, promoting neuronal proliferation, survival, and differentiation. IGF-1/GLP-1 is a growth factor that stimulates neur...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846475/ https://www.ncbi.nlm.nih.gov/pubmed/36685765 http://dx.doi.org/10.1016/j.crneur.2022.100055 |
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author | Siddiqui, Ehraz Mehmood Mehan, Sidharth Bhalla, Sonalika Shandilya, Ambika |
author_facet | Siddiqui, Ehraz Mehmood Mehan, Sidharth Bhalla, Sonalika Shandilya, Ambika |
author_sort | Siddiqui, Ehraz Mehmood |
collection | PubMed |
description | IGF-1 and GLP-1 receptors are essential in all tissues, facilitating defense by upregulating anabolic processes. They are abundantly distributed throughout the central nervous system, promoting neuronal proliferation, survival, and differentiation. IGF-1/GLP-1 is a growth factor that stimulates neurons' development, reorganization, myelination, and survival. In primary and secondary brain injury, the IGF-1/GLP-1 receptors are impaired, resulting in further neuro complications such as cerebral tissue degradation, neuroinflammation, oxidative stress, and atrophy. Intracerebral hemorrhage (ICH) is a severe condition caused by a stroke for which there is currently no effective treatment. While some pre-clinical studies and medications are being developed as symptomatic therapies in clinical trials, there are specific pharmacological implications for improving post-operative conditions in patients with intensive treatment. Identifying the underlying molecular process and recognizing the worsening situation can assist researchers in developing effective therapeutic solutions to prevent post-hemorrhagic symptoms and the associated neural dysfunctions. As a result, in the current review, we have addressed the manifestations of the disease that are aggravated by the downregulation of IGF-1 and GLP-1 receptors, which can lead to ICH or other neurodegenerative disorders. Our review summarizes that IGF-1/GLP-1 activators may be useful for treating ICH and its related neurodegeneration. |
format | Online Article Text |
id | pubmed-9846475 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-98464752023-01-19 Potential role of IGF-1/GLP-1 signaling activation in intracerebral hemorrhage Siddiqui, Ehraz Mehmood Mehan, Sidharth Bhalla, Sonalika Shandilya, Ambika Curr Res Neurobiol Review Article IGF-1 and GLP-1 receptors are essential in all tissues, facilitating defense by upregulating anabolic processes. They are abundantly distributed throughout the central nervous system, promoting neuronal proliferation, survival, and differentiation. IGF-1/GLP-1 is a growth factor that stimulates neurons' development, reorganization, myelination, and survival. In primary and secondary brain injury, the IGF-1/GLP-1 receptors are impaired, resulting in further neuro complications such as cerebral tissue degradation, neuroinflammation, oxidative stress, and atrophy. Intracerebral hemorrhage (ICH) is a severe condition caused by a stroke for which there is currently no effective treatment. While some pre-clinical studies and medications are being developed as symptomatic therapies in clinical trials, there are specific pharmacological implications for improving post-operative conditions in patients with intensive treatment. Identifying the underlying molecular process and recognizing the worsening situation can assist researchers in developing effective therapeutic solutions to prevent post-hemorrhagic symptoms and the associated neural dysfunctions. As a result, in the current review, we have addressed the manifestations of the disease that are aggravated by the downregulation of IGF-1 and GLP-1 receptors, which can lead to ICH or other neurodegenerative disorders. Our review summarizes that IGF-1/GLP-1 activators may be useful for treating ICH and its related neurodegeneration. Elsevier 2022-09-10 /pmc/articles/PMC9846475/ /pubmed/36685765 http://dx.doi.org/10.1016/j.crneur.2022.100055 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Siddiqui, Ehraz Mehmood Mehan, Sidharth Bhalla, Sonalika Shandilya, Ambika Potential role of IGF-1/GLP-1 signaling activation in intracerebral hemorrhage |
title | Potential role of IGF-1/GLP-1 signaling activation in intracerebral hemorrhage |
title_full | Potential role of IGF-1/GLP-1 signaling activation in intracerebral hemorrhage |
title_fullStr | Potential role of IGF-1/GLP-1 signaling activation in intracerebral hemorrhage |
title_full_unstemmed | Potential role of IGF-1/GLP-1 signaling activation in intracerebral hemorrhage |
title_short | Potential role of IGF-1/GLP-1 signaling activation in intracerebral hemorrhage |
title_sort | potential role of igf-1/glp-1 signaling activation in intracerebral hemorrhage |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846475/ https://www.ncbi.nlm.nih.gov/pubmed/36685765 http://dx.doi.org/10.1016/j.crneur.2022.100055 |
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