Cargando…
Increase of ALCAM and VCAM-1 in the plasma predicts the Alzheimer’s disease
Cell adhesion molecules (CAM) are crucial in several pathological inflammation processes in Alzheimer’s disease (AD). However, their potential for clinical diagnostics remains unknown. The present investigation evaluated the clinical significance of ALCAM, VCAM-1, NCAM, and ICAM-1 levels in the plas...
Autores principales: | , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846483/ https://www.ncbi.nlm.nih.gov/pubmed/36685605 http://dx.doi.org/10.3389/fimmu.2022.1097409 |
_version_ | 1784871189827551232 |
---|---|
author | Chen, Jian Dai, An-Xiang Tang, Hai-Liang Lu, Chang-Hao Liu, Hao-Xin Hou, Ting Lu, Zhi-Jie Kong, Nan Peng, Xin-Yuan Lin, Kai-Xun Zheng, Zi-Dong Xu, Sheng-Liang Ying, Xiao-Fang Ji, Xiao-Yu Pan, Hui Wu, Jie Zeng, Xin Wei, Nai-Li |
author_facet | Chen, Jian Dai, An-Xiang Tang, Hai-Liang Lu, Chang-Hao Liu, Hao-Xin Hou, Ting Lu, Zhi-Jie Kong, Nan Peng, Xin-Yuan Lin, Kai-Xun Zheng, Zi-Dong Xu, Sheng-Liang Ying, Xiao-Fang Ji, Xiao-Yu Pan, Hui Wu, Jie Zeng, Xin Wei, Nai-Li |
author_sort | Chen, Jian |
collection | PubMed |
description | Cell adhesion molecules (CAM) are crucial in several pathological inflammation processes in Alzheimer’s disease (AD). However, their potential for clinical diagnostics remains unknown. The present investigation evaluated the clinical significance of ALCAM, VCAM-1, NCAM, and ICAM-1 levels in the plasma of participants with cognitive impairment (44 patients with mild cognitive impairment, 71 patients with Alzheimer’s dementia, and 18 patients with other dementia) and 28 controls with normal cognitive ability. We also detected plasma levels of multiple inflammatory factors (IFN-gamma, IL-18, IL-1beta, IL-13, IL-8, IL-7, CCL11, MCP-1, TSLP, IL-10, BDNF, IL-17, IL-5, TREM-1) using Multiplex liquid chip and plasma levels of Abeta1-42 and Abeta1-40 using liquid-phase flow cytometry (FCM). Our findings demonstrated a correlation of ALCAM and VCAM-1 with age, the severity of cognitive decline, and MTA, but no significant difference between groups for NCAM and ICAM-1. ALCAM and VCAM-1 both demonstrated a positive correlation with the degree of atrophy in the medial temporal lobe structure. Further analysis revealed no significant correlation in plasma between VCAM-1, ALCAM and Abeta1-40, Abeta1-42. Nevertheless, there was a significant correlation between VCAM-1, ALCAM and many inflammatory factors. Furthermore, the predictive value of ALCAM and VCAM-1 for AD was assessed using a multi-parameter regression model. ALCAM and VCAM-1 in combination with ApoE4, education, age, and MMSE could predict AD with high precision (AUC=0.891; AIC=146.9) without imaging diagnosis. ALCAM and VCAM-1 combination improved the predictive accuracy significantly. In a nutshell, these findings revealed ALCAM and VCAM-1 as reliable indicators of Alzheimer’s disease. |
format | Online Article Text |
id | pubmed-9846483 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98464832023-01-19 Increase of ALCAM and VCAM-1 in the plasma predicts the Alzheimer’s disease Chen, Jian Dai, An-Xiang Tang, Hai-Liang Lu, Chang-Hao Liu, Hao-Xin Hou, Ting Lu, Zhi-Jie Kong, Nan Peng, Xin-Yuan Lin, Kai-Xun Zheng, Zi-Dong Xu, Sheng-Liang Ying, Xiao-Fang Ji, Xiao-Yu Pan, Hui Wu, Jie Zeng, Xin Wei, Nai-Li Front Immunol Immunology Cell adhesion molecules (CAM) are crucial in several pathological inflammation processes in Alzheimer’s disease (AD). However, their potential for clinical diagnostics remains unknown. The present investigation evaluated the clinical significance of ALCAM, VCAM-1, NCAM, and ICAM-1 levels in the plasma of participants with cognitive impairment (44 patients with mild cognitive impairment, 71 patients with Alzheimer’s dementia, and 18 patients with other dementia) and 28 controls with normal cognitive ability. We also detected plasma levels of multiple inflammatory factors (IFN-gamma, IL-18, IL-1beta, IL-13, IL-8, IL-7, CCL11, MCP-1, TSLP, IL-10, BDNF, IL-17, IL-5, TREM-1) using Multiplex liquid chip and plasma levels of Abeta1-42 and Abeta1-40 using liquid-phase flow cytometry (FCM). Our findings demonstrated a correlation of ALCAM and VCAM-1 with age, the severity of cognitive decline, and MTA, but no significant difference between groups for NCAM and ICAM-1. ALCAM and VCAM-1 both demonstrated a positive correlation with the degree of atrophy in the medial temporal lobe structure. Further analysis revealed no significant correlation in plasma between VCAM-1, ALCAM and Abeta1-40, Abeta1-42. Nevertheless, there was a significant correlation between VCAM-1, ALCAM and many inflammatory factors. Furthermore, the predictive value of ALCAM and VCAM-1 for AD was assessed using a multi-parameter regression model. ALCAM and VCAM-1 in combination with ApoE4, education, age, and MMSE could predict AD with high precision (AUC=0.891; AIC=146.9) without imaging diagnosis. ALCAM and VCAM-1 combination improved the predictive accuracy significantly. In a nutshell, these findings revealed ALCAM and VCAM-1 as reliable indicators of Alzheimer’s disease. Frontiers Media S.A. 2023-01-04 /pmc/articles/PMC9846483/ /pubmed/36685605 http://dx.doi.org/10.3389/fimmu.2022.1097409 Text en Copyright © 2023 Chen, Dai, Tang, Lu, Liu, Hou, Lu, Kong, Peng, Lin, Zheng, Xu, Ying, Ji, Pan, Wu, Zeng and Wei https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Chen, Jian Dai, An-Xiang Tang, Hai-Liang Lu, Chang-Hao Liu, Hao-Xin Hou, Ting Lu, Zhi-Jie Kong, Nan Peng, Xin-Yuan Lin, Kai-Xun Zheng, Zi-Dong Xu, Sheng-Liang Ying, Xiao-Fang Ji, Xiao-Yu Pan, Hui Wu, Jie Zeng, Xin Wei, Nai-Li Increase of ALCAM and VCAM-1 in the plasma predicts the Alzheimer’s disease |
title | Increase of ALCAM and VCAM-1 in the plasma predicts the Alzheimer’s disease |
title_full | Increase of ALCAM and VCAM-1 in the plasma predicts the Alzheimer’s disease |
title_fullStr | Increase of ALCAM and VCAM-1 in the plasma predicts the Alzheimer’s disease |
title_full_unstemmed | Increase of ALCAM and VCAM-1 in the plasma predicts the Alzheimer’s disease |
title_short | Increase of ALCAM and VCAM-1 in the plasma predicts the Alzheimer’s disease |
title_sort | increase of alcam and vcam-1 in the plasma predicts the alzheimer’s disease |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846483/ https://www.ncbi.nlm.nih.gov/pubmed/36685605 http://dx.doi.org/10.3389/fimmu.2022.1097409 |
work_keys_str_mv | AT chenjian increaseofalcamandvcam1intheplasmapredictsthealzheimersdisease AT daianxiang increaseofalcamandvcam1intheplasmapredictsthealzheimersdisease AT tanghailiang increaseofalcamandvcam1intheplasmapredictsthealzheimersdisease AT luchanghao increaseofalcamandvcam1intheplasmapredictsthealzheimersdisease AT liuhaoxin increaseofalcamandvcam1intheplasmapredictsthealzheimersdisease AT houting increaseofalcamandvcam1intheplasmapredictsthealzheimersdisease AT luzhijie increaseofalcamandvcam1intheplasmapredictsthealzheimersdisease AT kongnan increaseofalcamandvcam1intheplasmapredictsthealzheimersdisease AT pengxinyuan increaseofalcamandvcam1intheplasmapredictsthealzheimersdisease AT linkaixun increaseofalcamandvcam1intheplasmapredictsthealzheimersdisease AT zhengzidong increaseofalcamandvcam1intheplasmapredictsthealzheimersdisease AT xushengliang increaseofalcamandvcam1intheplasmapredictsthealzheimersdisease AT yingxiaofang increaseofalcamandvcam1intheplasmapredictsthealzheimersdisease AT jixiaoyu increaseofalcamandvcam1intheplasmapredictsthealzheimersdisease AT panhui increaseofalcamandvcam1intheplasmapredictsthealzheimersdisease AT wujie increaseofalcamandvcam1intheplasmapredictsthealzheimersdisease AT zengxin increaseofalcamandvcam1intheplasmapredictsthealzheimersdisease AT weinaili increaseofalcamandvcam1intheplasmapredictsthealzheimersdisease |