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Increase of ALCAM and VCAM-1 in the plasma predicts the Alzheimer’s disease

Cell adhesion molecules (CAM) are crucial in several pathological inflammation processes in Alzheimer’s disease (AD). However, their potential for clinical diagnostics remains unknown. The present investigation evaluated the clinical significance of ALCAM, VCAM-1, NCAM, and ICAM-1 levels in the plas...

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Autores principales: Chen, Jian, Dai, An-Xiang, Tang, Hai-Liang, Lu, Chang-Hao, Liu, Hao-Xin, Hou, Ting, Lu, Zhi-Jie, Kong, Nan, Peng, Xin-Yuan, Lin, Kai-Xun, Zheng, Zi-Dong, Xu, Sheng-Liang, Ying, Xiao-Fang, Ji, Xiao-Yu, Pan, Hui, Wu, Jie, Zeng, Xin, Wei, Nai-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846483/
https://www.ncbi.nlm.nih.gov/pubmed/36685605
http://dx.doi.org/10.3389/fimmu.2022.1097409
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author Chen, Jian
Dai, An-Xiang
Tang, Hai-Liang
Lu, Chang-Hao
Liu, Hao-Xin
Hou, Ting
Lu, Zhi-Jie
Kong, Nan
Peng, Xin-Yuan
Lin, Kai-Xun
Zheng, Zi-Dong
Xu, Sheng-Liang
Ying, Xiao-Fang
Ji, Xiao-Yu
Pan, Hui
Wu, Jie
Zeng, Xin
Wei, Nai-Li
author_facet Chen, Jian
Dai, An-Xiang
Tang, Hai-Liang
Lu, Chang-Hao
Liu, Hao-Xin
Hou, Ting
Lu, Zhi-Jie
Kong, Nan
Peng, Xin-Yuan
Lin, Kai-Xun
Zheng, Zi-Dong
Xu, Sheng-Liang
Ying, Xiao-Fang
Ji, Xiao-Yu
Pan, Hui
Wu, Jie
Zeng, Xin
Wei, Nai-Li
author_sort Chen, Jian
collection PubMed
description Cell adhesion molecules (CAM) are crucial in several pathological inflammation processes in Alzheimer’s disease (AD). However, their potential for clinical diagnostics remains unknown. The present investigation evaluated the clinical significance of ALCAM, VCAM-1, NCAM, and ICAM-1 levels in the plasma of participants with cognitive impairment (44 patients with mild cognitive impairment, 71 patients with Alzheimer’s dementia, and 18 patients with other dementia) and 28 controls with normal cognitive ability. We also detected plasma levels of multiple inflammatory factors (IFN-gamma, IL-18, IL-1beta, IL-13, IL-8, IL-7, CCL11, MCP-1, TSLP, IL-10, BDNF, IL-17, IL-5, TREM-1) using Multiplex liquid chip and plasma levels of Abeta1-42 and Abeta1-40 using liquid-phase flow cytometry (FCM). Our findings demonstrated a correlation of ALCAM and VCAM-1 with age, the severity of cognitive decline, and MTA, but no significant difference between groups for NCAM and ICAM-1. ALCAM and VCAM-1 both demonstrated a positive correlation with the degree of atrophy in the medial temporal lobe structure. Further analysis revealed no significant correlation in plasma between VCAM-1, ALCAM and Abeta1-40, Abeta1-42. Nevertheless, there was a significant correlation between VCAM-1, ALCAM and many inflammatory factors. Furthermore, the predictive value of ALCAM and VCAM-1 for AD was assessed using a multi-parameter regression model. ALCAM and VCAM-1 in combination with ApoE4, education, age, and MMSE could predict AD with high precision (AUC=0.891; AIC=146.9) without imaging diagnosis. ALCAM and VCAM-1 combination improved the predictive accuracy significantly. In a nutshell, these findings revealed ALCAM and VCAM-1 as reliable indicators of Alzheimer’s disease.
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spelling pubmed-98464832023-01-19 Increase of ALCAM and VCAM-1 in the plasma predicts the Alzheimer’s disease Chen, Jian Dai, An-Xiang Tang, Hai-Liang Lu, Chang-Hao Liu, Hao-Xin Hou, Ting Lu, Zhi-Jie Kong, Nan Peng, Xin-Yuan Lin, Kai-Xun Zheng, Zi-Dong Xu, Sheng-Liang Ying, Xiao-Fang Ji, Xiao-Yu Pan, Hui Wu, Jie Zeng, Xin Wei, Nai-Li Front Immunol Immunology Cell adhesion molecules (CAM) are crucial in several pathological inflammation processes in Alzheimer’s disease (AD). However, their potential for clinical diagnostics remains unknown. The present investigation evaluated the clinical significance of ALCAM, VCAM-1, NCAM, and ICAM-1 levels in the plasma of participants with cognitive impairment (44 patients with mild cognitive impairment, 71 patients with Alzheimer’s dementia, and 18 patients with other dementia) and 28 controls with normal cognitive ability. We also detected plasma levels of multiple inflammatory factors (IFN-gamma, IL-18, IL-1beta, IL-13, IL-8, IL-7, CCL11, MCP-1, TSLP, IL-10, BDNF, IL-17, IL-5, TREM-1) using Multiplex liquid chip and plasma levels of Abeta1-42 and Abeta1-40 using liquid-phase flow cytometry (FCM). Our findings demonstrated a correlation of ALCAM and VCAM-1 with age, the severity of cognitive decline, and MTA, but no significant difference between groups for NCAM and ICAM-1. ALCAM and VCAM-1 both demonstrated a positive correlation with the degree of atrophy in the medial temporal lobe structure. Further analysis revealed no significant correlation in plasma between VCAM-1, ALCAM and Abeta1-40, Abeta1-42. Nevertheless, there was a significant correlation between VCAM-1, ALCAM and many inflammatory factors. Furthermore, the predictive value of ALCAM and VCAM-1 for AD was assessed using a multi-parameter regression model. ALCAM and VCAM-1 in combination with ApoE4, education, age, and MMSE could predict AD with high precision (AUC=0.891; AIC=146.9) without imaging diagnosis. ALCAM and VCAM-1 combination improved the predictive accuracy significantly. In a nutshell, these findings revealed ALCAM and VCAM-1 as reliable indicators of Alzheimer’s disease. Frontiers Media S.A. 2023-01-04 /pmc/articles/PMC9846483/ /pubmed/36685605 http://dx.doi.org/10.3389/fimmu.2022.1097409 Text en Copyright © 2023 Chen, Dai, Tang, Lu, Liu, Hou, Lu, Kong, Peng, Lin, Zheng, Xu, Ying, Ji, Pan, Wu, Zeng and Wei https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Chen, Jian
Dai, An-Xiang
Tang, Hai-Liang
Lu, Chang-Hao
Liu, Hao-Xin
Hou, Ting
Lu, Zhi-Jie
Kong, Nan
Peng, Xin-Yuan
Lin, Kai-Xun
Zheng, Zi-Dong
Xu, Sheng-Liang
Ying, Xiao-Fang
Ji, Xiao-Yu
Pan, Hui
Wu, Jie
Zeng, Xin
Wei, Nai-Li
Increase of ALCAM and VCAM-1 in the plasma predicts the Alzheimer’s disease
title Increase of ALCAM and VCAM-1 in the plasma predicts the Alzheimer’s disease
title_full Increase of ALCAM and VCAM-1 in the plasma predicts the Alzheimer’s disease
title_fullStr Increase of ALCAM and VCAM-1 in the plasma predicts the Alzheimer’s disease
title_full_unstemmed Increase of ALCAM and VCAM-1 in the plasma predicts the Alzheimer’s disease
title_short Increase of ALCAM and VCAM-1 in the plasma predicts the Alzheimer’s disease
title_sort increase of alcam and vcam-1 in the plasma predicts the alzheimer’s disease
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846483/
https://www.ncbi.nlm.nih.gov/pubmed/36685605
http://dx.doi.org/10.3389/fimmu.2022.1097409
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