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Relationship between the image characteristics of artificial intelligence and EGFR gene mutation in lung adenocarcinoma

Lung Adenocarcinoma (LUAD) is a kind of Lung Cancer (LCA) with high incidence rate, which is very harmful to human body. It is hidden in the human body and is not easy to be discovered, so it brings great inconvenience to the treatment of LUAD. Artificial Intelligence (AI) technology provides techni...

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Autores principales: Zhou, Guoping, Xu, Shuhua, Liu, Xiaoli, Ge, Jingjun, He, Qiyu, Cao, Weikang, Ding, Junning, Kai, Xinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846484/
https://www.ncbi.nlm.nih.gov/pubmed/36685887
http://dx.doi.org/10.3389/fgene.2022.1090180
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author Zhou, Guoping
Xu, Shuhua
Liu, Xiaoli
Ge, Jingjun
He, Qiyu
Cao, Weikang
Ding, Junning
Kai, Xinghua
author_facet Zhou, Guoping
Xu, Shuhua
Liu, Xiaoli
Ge, Jingjun
He, Qiyu
Cao, Weikang
Ding, Junning
Kai, Xinghua
author_sort Zhou, Guoping
collection PubMed
description Lung Adenocarcinoma (LUAD) is a kind of Lung Cancer (LCA) with high incidence rate, which is very harmful to human body. It is hidden in the human body and is not easy to be discovered, so it brings great inconvenience to the treatment of LUAD. Artificial Intelligence (AI) technology provides technical support for the diagnosis and treatment of LUAD and has great application space in intelligent medicine. In this paper, 164 patients with primary LUAD who underwent surgery in Hospital A from January 2020 to December 2021 were selected as the study subjects, and the correlation between the imaging characteristics of LUAD and Epidermal Growth Factor Receptor (EGFR) gene mutation was analyzed. Finally, the conclusion was drawn. In terms of the study on the correlation between EGFR mutation of LUAD and the imaging characteristics of Computed Tomography (CT), it was concluded that there were significant differences between the patient’s sex, smoking history, pulmonary nodule morphology and the EGFR gene, and there was no significant difference between the patient’s tumor size and EGFR gene; in the study of the relationship between EGFR gene mutation and CT signs of LUAD lesions, it was found that there were significant differences between the symptoms of cavity sign, hair prick sign and chest depression sign and EGFR gene, but there was no significant difference between the symptoms of lobulation sign and EGFR gene; in the study of pathological subtype and EGFR gene mutation status of LUAD patients, it was concluded that the pathological subtype was mainly micropapillary. The mutation rate was 44.44%, which was the highest; in terms of CT manifestations of adjacent structures of lung cancer and the study of EGFR gene mutation status, it was found that there was a statistical difference between the tumor with vascular convergence sign and EGFR gene mutation, and pleural effusion, pericardial effusion, pleural thickening and other signs in tumor imaging were not significantly associated with EGFR gene mutation; in terms of the study of CT manifestations of adjacent structures of LCA and EGFR gene mutation status, it was concluded that pleural effusion, pericardial effusion, pleural thickening and other signs in tumor images were not significantly associated with EGFR gene mutation; in terms of analysis and cure of LUAD, it was concluded that the cure rate of patients was relatively high, and only a few people died of ineffective treatment. This paper provided a reference for the field of intelligent medicine and physical health.
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spelling pubmed-98464842023-01-19 Relationship between the image characteristics of artificial intelligence and EGFR gene mutation in lung adenocarcinoma Zhou, Guoping Xu, Shuhua Liu, Xiaoli Ge, Jingjun He, Qiyu Cao, Weikang Ding, Junning Kai, Xinghua Front Genet Genetics Lung Adenocarcinoma (LUAD) is a kind of Lung Cancer (LCA) with high incidence rate, which is very harmful to human body. It is hidden in the human body and is not easy to be discovered, so it brings great inconvenience to the treatment of LUAD. Artificial Intelligence (AI) technology provides technical support for the diagnosis and treatment of LUAD and has great application space in intelligent medicine. In this paper, 164 patients with primary LUAD who underwent surgery in Hospital A from January 2020 to December 2021 were selected as the study subjects, and the correlation between the imaging characteristics of LUAD and Epidermal Growth Factor Receptor (EGFR) gene mutation was analyzed. Finally, the conclusion was drawn. In terms of the study on the correlation between EGFR mutation of LUAD and the imaging characteristics of Computed Tomography (CT), it was concluded that there were significant differences between the patient’s sex, smoking history, pulmonary nodule morphology and the EGFR gene, and there was no significant difference between the patient’s tumor size and EGFR gene; in the study of the relationship between EGFR gene mutation and CT signs of LUAD lesions, it was found that there were significant differences between the symptoms of cavity sign, hair prick sign and chest depression sign and EGFR gene, but there was no significant difference between the symptoms of lobulation sign and EGFR gene; in the study of pathological subtype and EGFR gene mutation status of LUAD patients, it was concluded that the pathological subtype was mainly micropapillary. The mutation rate was 44.44%, which was the highest; in terms of CT manifestations of adjacent structures of lung cancer and the study of EGFR gene mutation status, it was found that there was a statistical difference between the tumor with vascular convergence sign and EGFR gene mutation, and pleural effusion, pericardial effusion, pleural thickening and other signs in tumor imaging were not significantly associated with EGFR gene mutation; in terms of the study of CT manifestations of adjacent structures of LCA and EGFR gene mutation status, it was concluded that pleural effusion, pericardial effusion, pleural thickening and other signs in tumor images were not significantly associated with EGFR gene mutation; in terms of analysis and cure of LUAD, it was concluded that the cure rate of patients was relatively high, and only a few people died of ineffective treatment. This paper provided a reference for the field of intelligent medicine and physical health. Frontiers Media S.A. 2023-01-04 /pmc/articles/PMC9846484/ /pubmed/36685887 http://dx.doi.org/10.3389/fgene.2022.1090180 Text en Copyright © 2023 Zhou, Xu, Liu, Ge, He, Cao, Ding and Kai. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Zhou, Guoping
Xu, Shuhua
Liu, Xiaoli
Ge, Jingjun
He, Qiyu
Cao, Weikang
Ding, Junning
Kai, Xinghua
Relationship between the image characteristics of artificial intelligence and EGFR gene mutation in lung adenocarcinoma
title Relationship between the image characteristics of artificial intelligence and EGFR gene mutation in lung adenocarcinoma
title_full Relationship between the image characteristics of artificial intelligence and EGFR gene mutation in lung adenocarcinoma
title_fullStr Relationship between the image characteristics of artificial intelligence and EGFR gene mutation in lung adenocarcinoma
title_full_unstemmed Relationship between the image characteristics of artificial intelligence and EGFR gene mutation in lung adenocarcinoma
title_short Relationship between the image characteristics of artificial intelligence and EGFR gene mutation in lung adenocarcinoma
title_sort relationship between the image characteristics of artificial intelligence and egfr gene mutation in lung adenocarcinoma
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846484/
https://www.ncbi.nlm.nih.gov/pubmed/36685887
http://dx.doi.org/10.3389/fgene.2022.1090180
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