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Acute phase characteristics and long-term complications of pulmonary embolism in COVID-19 compared to non-COVID-19 cohort: a large single-centre study
BACKGROUND: To compare the severity of pulmonary embolism (PE) and the long-term complications between patients with and without COVID-19, and to investigate whether the tools for risk stratification of death are valid in this population. METHODS: We retrospectively included hospitalized patients wi...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846660/ https://www.ncbi.nlm.nih.gov/pubmed/36653788 http://dx.doi.org/10.1186/s12890-023-02323-9 |
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author | Franco-Moreno, A. Brown-Lavalle, D. Campos-Arenas, M. Rodríguez-Ramírez, N. Muñoz-Roldán, C. Rubio-Aguilera, A. I. Muñoz-Rivas, N. de Girón, J. Bascuñana-Morejón Fernández-Vidal, E. Palma-Huerta, E. Estévez-Alonso, S. Rodríguez-Gómez, B. Manzano-Valera, S. Pedrero-Tomé, R. Casado-Suela, M. Bibiano-Guillén, C. Mir-Montero, M. Torres-Macho, J. Bustamante-Fermosel, A. |
author_facet | Franco-Moreno, A. Brown-Lavalle, D. Campos-Arenas, M. Rodríguez-Ramírez, N. Muñoz-Roldán, C. Rubio-Aguilera, A. I. Muñoz-Rivas, N. de Girón, J. Bascuñana-Morejón Fernández-Vidal, E. Palma-Huerta, E. Estévez-Alonso, S. Rodríguez-Gómez, B. Manzano-Valera, S. Pedrero-Tomé, R. Casado-Suela, M. Bibiano-Guillén, C. Mir-Montero, M. Torres-Macho, J. Bustamante-Fermosel, A. |
author_sort | Franco-Moreno, A. |
collection | PubMed |
description | BACKGROUND: To compare the severity of pulmonary embolism (PE) and the long-term complications between patients with and without COVID-19, and to investigate whether the tools for risk stratification of death are valid in this population. METHODS: We retrospectively included hospitalized patients with PE from 1 January 2016 to 31 December 2022. Comparisons for acute episode characteristics, risk stratification of the PE, outcomes, and long-term complications were made between COVID and non-COVID patients. RESULTS: We analyzed 116 (27.5%) COVID patients and 305 (72.4%) non-COVID patients. In patients with COVID-19, the traditional risk factors for PE were absent, and the incidence of deep vein thrombosis was lower. COVID patients showed significantly higher lymphocyte count, lactate dehydrogenase, lactic acid, and D-dimer levels. COVID patients had PE of smaller size (12.3% vs. 25.5% main pulmonary artery, 29.8% vs. 37.1% lobar, 44.7% vs. 29.5% segmental and 13.2% vs. 7.9% subsegmental, respectively; p < 0.001), less right ventricular dysfunction (7.7% vs. 17.7%; p = 0.007) and higher sPESI score (1.66 vs. 1.11; p < 0.001). The need for mechanical ventilation was significantly higher in COVID patients (8.6% vs. 1.3%; p < 0.001); However, the in-hospital death was less (5.2% vs. 10.8%; p = 0.074). The incidence of long-term complications was lower in COVID cohort (p < 0.001). PE severity assessed by high sPESI and intermediate and high-risk categories were independently associated with in-hospital mortality in COVID patients. CONCLUSION: The risk of in-hospital mortality and the incidence of long-term complications were lower in COVID-19. The usual tools for risk stratification of PE are valid in COVID patients. |
format | Online Article Text |
id | pubmed-9846660 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-98466602023-01-18 Acute phase characteristics and long-term complications of pulmonary embolism in COVID-19 compared to non-COVID-19 cohort: a large single-centre study Franco-Moreno, A. Brown-Lavalle, D. Campos-Arenas, M. Rodríguez-Ramírez, N. Muñoz-Roldán, C. Rubio-Aguilera, A. I. Muñoz-Rivas, N. de Girón, J. Bascuñana-Morejón Fernández-Vidal, E. Palma-Huerta, E. Estévez-Alonso, S. Rodríguez-Gómez, B. Manzano-Valera, S. Pedrero-Tomé, R. Casado-Suela, M. Bibiano-Guillén, C. Mir-Montero, M. Torres-Macho, J. Bustamante-Fermosel, A. BMC Pulm Med Research Article BACKGROUND: To compare the severity of pulmonary embolism (PE) and the long-term complications between patients with and without COVID-19, and to investigate whether the tools for risk stratification of death are valid in this population. METHODS: We retrospectively included hospitalized patients with PE from 1 January 2016 to 31 December 2022. Comparisons for acute episode characteristics, risk stratification of the PE, outcomes, and long-term complications were made between COVID and non-COVID patients. RESULTS: We analyzed 116 (27.5%) COVID patients and 305 (72.4%) non-COVID patients. In patients with COVID-19, the traditional risk factors for PE were absent, and the incidence of deep vein thrombosis was lower. COVID patients showed significantly higher lymphocyte count, lactate dehydrogenase, lactic acid, and D-dimer levels. COVID patients had PE of smaller size (12.3% vs. 25.5% main pulmonary artery, 29.8% vs. 37.1% lobar, 44.7% vs. 29.5% segmental and 13.2% vs. 7.9% subsegmental, respectively; p < 0.001), less right ventricular dysfunction (7.7% vs. 17.7%; p = 0.007) and higher sPESI score (1.66 vs. 1.11; p < 0.001). The need for mechanical ventilation was significantly higher in COVID patients (8.6% vs. 1.3%; p < 0.001); However, the in-hospital death was less (5.2% vs. 10.8%; p = 0.074). The incidence of long-term complications was lower in COVID cohort (p < 0.001). PE severity assessed by high sPESI and intermediate and high-risk categories were independently associated with in-hospital mortality in COVID patients. CONCLUSION: The risk of in-hospital mortality and the incidence of long-term complications were lower in COVID-19. The usual tools for risk stratification of PE are valid in COVID patients. BioMed Central 2023-01-18 /pmc/articles/PMC9846660/ /pubmed/36653788 http://dx.doi.org/10.1186/s12890-023-02323-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Franco-Moreno, A. Brown-Lavalle, D. Campos-Arenas, M. Rodríguez-Ramírez, N. Muñoz-Roldán, C. Rubio-Aguilera, A. I. Muñoz-Rivas, N. de Girón, J. Bascuñana-Morejón Fernández-Vidal, E. Palma-Huerta, E. Estévez-Alonso, S. Rodríguez-Gómez, B. Manzano-Valera, S. Pedrero-Tomé, R. Casado-Suela, M. Bibiano-Guillén, C. Mir-Montero, M. Torres-Macho, J. Bustamante-Fermosel, A. Acute phase characteristics and long-term complications of pulmonary embolism in COVID-19 compared to non-COVID-19 cohort: a large single-centre study |
title | Acute phase characteristics and long-term complications of pulmonary embolism in COVID-19 compared to non-COVID-19 cohort: a large single-centre study |
title_full | Acute phase characteristics and long-term complications of pulmonary embolism in COVID-19 compared to non-COVID-19 cohort: a large single-centre study |
title_fullStr | Acute phase characteristics and long-term complications of pulmonary embolism in COVID-19 compared to non-COVID-19 cohort: a large single-centre study |
title_full_unstemmed | Acute phase characteristics and long-term complications of pulmonary embolism in COVID-19 compared to non-COVID-19 cohort: a large single-centre study |
title_short | Acute phase characteristics and long-term complications of pulmonary embolism in COVID-19 compared to non-COVID-19 cohort: a large single-centre study |
title_sort | acute phase characteristics and long-term complications of pulmonary embolism in covid-19 compared to non-covid-19 cohort: a large single-centre study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846660/ https://www.ncbi.nlm.nih.gov/pubmed/36653788 http://dx.doi.org/10.1186/s12890-023-02323-9 |
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