Cisplatin Binding to Human Serum Transferrin: A Crystallographic Study

[Image: see text] The molecular mechanism of how human serum transferrin (hTF) recognizes cisplatin at the atomic level is still unclear. Here, we report the molecular structure of the adduct formed upon the reaction of hTF with cisplatin. Pt binds the side chain of Met256 (at the N-lobe), without a...

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Detalles Bibliográficos
Autores principales: Troisi, Romualdo, Galardo, Francesco, Ferraro, Giarita, Sica, Filomena, Merlino, Antonello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846693/
https://www.ncbi.nlm.nih.gov/pubmed/36602395
http://dx.doi.org/10.1021/acs.inorgchem.2c04206
Descripción
Sumario:[Image: see text] The molecular mechanism of how human serum transferrin (hTF) recognizes cisplatin at the atomic level is still unclear. Here, we report the molecular structure of the adduct formed upon the reaction of hTF with cisplatin. Pt binds the side chain of Met256 (at the N-lobe), without altering the protein overall conformation.

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