Fetal demise and SARS-CoV-2 infection during pregnancy: Histopathological and immunohistochemical findings of three cases referred to the Colombian National Institute of Health

Background: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection during pregnancy is related with adverse maternal, fetal, and neonatal outcomes. Placental SARS-CoV-2 involvement may include various degrees of inflammation and malperfusion leading to diverse pregnancy complica...

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Autores principales: Daza, Marcela, Corchuelo, Sheryll, Osorio, Johana, Alberto Gómez, Luis, Parra, Edgar, Alarcón, Ángela, Mercado, Marcela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of British Infection Association. 2023
Materias:
Case Reports and Series
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846883/
https://www.ncbi.nlm.nih.gov/pubmed/36687140
http://dx.doi.org/10.1016/j.clinpr.2023.100219
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author Daza, Marcela
Corchuelo, Sheryll
Osorio, Johana
Alberto Gómez, Luis
Parra, Edgar
Alarcón, Ángela
Mercado, Marcela
author_facet Daza, Marcela
Corchuelo, Sheryll
Osorio, Johana
Alberto Gómez, Luis
Parra, Edgar
Alarcón, Ángela
Mercado, Marcela
author_sort Daza, Marcela
collection PubMed
description Background: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection during pregnancy is related with adverse maternal, fetal, and neonatal outcomes. Placental SARS-CoV-2 involvement may include various degrees of inflammation and malperfusion leading to diverse pregnancy complications. Methods: Placental, fetal and umbilical cord samples of three fetal demise cases that occurred in the context of maternal SARS-CoV-2 infections were analyzed. Cases were notified to the Colombian SARS-CoV-2 National Surveillance System. RT-PCR and immunohistochemistry (IHC) analysis were employed to identify potential tissue viral involvement. Results: RT-PCR and IHC confirmed the presence of viral genomes and antigens in placental and umbilical cord tissues. Histopathological analysis revealed findings consistent with placental malperfusion and inflammation. Conclusions: SARS-CoV-2 infection during pregnancy can lead to placental dysfunction and damage compromising fetal survival. Many questions regarding SARS-CoV-2 dynamics during pregnancy including placental physiopathology and in utero transmission are still pending definitive answers.
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spelling pubmed-98468832023-01-18 Fetal demise and SARS-CoV-2 infection during pregnancy: Histopathological and immunohistochemical findings of three cases referred to the Colombian National Institute of Health Daza, Marcela Corchuelo, Sheryll Osorio, Johana Alberto Gómez, Luis Parra, Edgar Alarcón, Ángela Mercado, Marcela Clin Infect Pract Case Reports and Series Background: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection during pregnancy is related with adverse maternal, fetal, and neonatal outcomes. Placental SARS-CoV-2 involvement may include various degrees of inflammation and malperfusion leading to diverse pregnancy complications. Methods: Placental, fetal and umbilical cord samples of three fetal demise cases that occurred in the context of maternal SARS-CoV-2 infections were analyzed. Cases were notified to the Colombian SARS-CoV-2 National Surveillance System. RT-PCR and immunohistochemistry (IHC) analysis were employed to identify potential tissue viral involvement. Results: RT-PCR and IHC confirmed the presence of viral genomes and antigens in placental and umbilical cord tissues. Histopathological analysis revealed findings consistent with placental malperfusion and inflammation. Conclusions: SARS-CoV-2 infection during pregnancy can lead to placental dysfunction and damage compromising fetal survival. Many questions regarding SARS-CoV-2 dynamics during pregnancy including placental physiopathology and in utero transmission are still pending definitive answers. The Authors. Published by Elsevier Ltd on behalf of British Infection Association. 2023-01 2023-01-18 /pmc/articles/PMC9846883/ /pubmed/36687140 http://dx.doi.org/10.1016/j.clinpr.2023.100219 Text en © 2023 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Case Reports and Series
Daza, Marcela
Corchuelo, Sheryll
Osorio, Johana
Alberto Gómez, Luis
Parra, Edgar
Alarcón, Ángela
Mercado, Marcela
Fetal demise and SARS-CoV-2 infection during pregnancy: Histopathological and immunohistochemical findings of three cases referred to the Colombian National Institute of Health
title Fetal demise and SARS-CoV-2 infection during pregnancy: Histopathological and immunohistochemical findings of three cases referred to the Colombian National Institute of Health
title_full Fetal demise and SARS-CoV-2 infection during pregnancy: Histopathological and immunohistochemical findings of three cases referred to the Colombian National Institute of Health
title_fullStr Fetal demise and SARS-CoV-2 infection during pregnancy: Histopathological and immunohistochemical findings of three cases referred to the Colombian National Institute of Health
title_full_unstemmed Fetal demise and SARS-CoV-2 infection during pregnancy: Histopathological and immunohistochemical findings of three cases referred to the Colombian National Institute of Health
title_short Fetal demise and SARS-CoV-2 infection during pregnancy: Histopathological and immunohistochemical findings of three cases referred to the Colombian National Institute of Health
title_sort fetal demise and sars-cov-2 infection during pregnancy: histopathological and immunohistochemical findings of three cases referred to the colombian national institute of health
topic Case Reports and Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846883/
https://www.ncbi.nlm.nih.gov/pubmed/36687140
http://dx.doi.org/10.1016/j.clinpr.2023.100219
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