Receptor-binding domain of SARS-CoV-2 is a functional αv-integrin agonist

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Among the novel mutations distinguishing SARS-CoV-2 from similar coronaviruses is a K403R substitution in the receptor-binding domain (RBD) of the viral spike (S) protein within its S1 region. This amino acid substitution occurs near the angiotensin-converting enzyme 2–binding interface and gives ri...

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Detalles Bibliográficos
Autores principales: Norris, Emma G., Pan, Xuan Sabrina, Hocking, Denise C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846890/
https://www.ncbi.nlm.nih.gov/pubmed/36669646
http://dx.doi.org/10.1016/j.jbc.2023.102922

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