Cargando…
Deployment of iron uptake machineries as targets against drug resistant strains of mycobacterium tuberculosis
Mycobacterium tuberculosis (MTB) requires a perpetual supply of iron for its sustenance. Iron scarcity and its limited availability in the host environment because of an encounter of various sites during the establishment of infection has led to the evolution of strategies for iron uptake, which inc...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846915/ https://www.ncbi.nlm.nih.gov/pubmed/36537405 http://dx.doi.org/10.4103/ijp.IJP_667_20 |
_version_ | 1784871307783962624 |
---|---|
author | Gokhale, Kunal Mohan Iyer, Aditya Manivannan |
author_facet | Gokhale, Kunal Mohan Iyer, Aditya Manivannan |
author_sort | Gokhale, Kunal Mohan |
collection | PubMed |
description | Mycobacterium tuberculosis (MTB) requires a perpetual supply of iron for its sustenance. Iron scarcity and its limited availability in the host environment because of an encounter of various sites during the establishment of infection has led to the evolution of strategies for iron uptake, which includes biosynthesis of iron-chelating molecules called siderophores, Heme uptake pathways, recently discovered host iron transport protein receptors like glyceraldehyde-3-phosphate dehydrogenase and the development of machinery for proper storage of the acquired iron and its regulation. The components of the iron uptake machineries are viable targets in multidrug-resistant tuberculosis, some of which include the MmpL3 heme transfer protein, MbtA enzyme, and the ESX-3 system, while employment of approaches like the synthesis of siderophore drug conjugates, heme analogs, xenosiderophores as drug delivery agents, and the blockade of siderophore recycling are encouraged too. Thus, the mentioned discoveries stand as promising targets against various strains of MTB. |
format | Online Article Text |
id | pubmed-9846915 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-98469152023-01-19 Deployment of iron uptake machineries as targets against drug resistant strains of mycobacterium tuberculosis Gokhale, Kunal Mohan Iyer, Aditya Manivannan Indian J Pharmacol Review Article Mycobacterium tuberculosis (MTB) requires a perpetual supply of iron for its sustenance. Iron scarcity and its limited availability in the host environment because of an encounter of various sites during the establishment of infection has led to the evolution of strategies for iron uptake, which includes biosynthesis of iron-chelating molecules called siderophores, Heme uptake pathways, recently discovered host iron transport protein receptors like glyceraldehyde-3-phosphate dehydrogenase and the development of machinery for proper storage of the acquired iron and its regulation. The components of the iron uptake machineries are viable targets in multidrug-resistant tuberculosis, some of which include the MmpL3 heme transfer protein, MbtA enzyme, and the ESX-3 system, while employment of approaches like the synthesis of siderophore drug conjugates, heme analogs, xenosiderophores as drug delivery agents, and the blockade of siderophore recycling are encouraged too. Thus, the mentioned discoveries stand as promising targets against various strains of MTB. Wolters Kluwer - Medknow 2022 2022-12-13 /pmc/articles/PMC9846915/ /pubmed/36537405 http://dx.doi.org/10.4103/ijp.IJP_667_20 Text en Copyright: © 2022 Indian Journal of Pharmacology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Gokhale, Kunal Mohan Iyer, Aditya Manivannan Deployment of iron uptake machineries as targets against drug resistant strains of mycobacterium tuberculosis |
title | Deployment of iron uptake machineries as targets against drug resistant strains of mycobacterium tuberculosis |
title_full | Deployment of iron uptake machineries as targets against drug resistant strains of mycobacterium tuberculosis |
title_fullStr | Deployment of iron uptake machineries as targets against drug resistant strains of mycobacterium tuberculosis |
title_full_unstemmed | Deployment of iron uptake machineries as targets against drug resistant strains of mycobacterium tuberculosis |
title_short | Deployment of iron uptake machineries as targets against drug resistant strains of mycobacterium tuberculosis |
title_sort | deployment of iron uptake machineries as targets against drug resistant strains of mycobacterium tuberculosis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846915/ https://www.ncbi.nlm.nih.gov/pubmed/36537405 http://dx.doi.org/10.4103/ijp.IJP_667_20 |
work_keys_str_mv | AT gokhalekunalmohan deploymentofironuptakemachineriesastargetsagainstdrugresistantstrainsofmycobacteriumtuberculosis AT iyeradityamanivannan deploymentofironuptakemachineriesastargetsagainstdrugresistantstrainsofmycobacteriumtuberculosis |