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Current opinion on the regulation of small intestinal magnesium absorption
Magnesium (Mg(2+)) has an important role in numerous biological functions, and Mg(2+) deficiency is associated with several diseases. Therefore, adequate intestinal absorption of Mg(2+) is vital for health. The small intestine was previously thought to absorb digested Mg(2+) exclusively through an u...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846944/ https://www.ncbi.nlm.nih.gov/pubmed/36687126 http://dx.doi.org/10.3748/wjg.v29.i2.332 |
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author | Chamniansawat, Siriporn Suksridechacin, Nasisorn Thongon, Narongrit |
author_facet | Chamniansawat, Siriporn Suksridechacin, Nasisorn Thongon, Narongrit |
author_sort | Chamniansawat, Siriporn |
collection | PubMed |
description | Magnesium (Mg(2+)) has an important role in numerous biological functions, and Mg(2+) deficiency is associated with several diseases. Therefore, adequate intestinal absorption of Mg(2+) is vital for health. The small intestine was previously thought to absorb digested Mg(2+) exclusively through an unregulated paracellular mechanism, which is responsible for approximately 90% of total Mg(2+) absorption. Recent studies, however, have revealed that the duodenum, jejunum, and ileum absorb Mg(2+) through both transcellular and paracellular routes. Several regulatory factors of small intestinal Mg(2+) uptake also have been explored, e.g., parathyroid hormone, fibroblast growth factor-23, apical acidity, proton pump inhibitor, and pH-sensing channel and receptors. The mechanistic factors underlying proton pump inhibitor suppression of small intestinal Mg(2+), such as magnesiotropic protein dysfunction, higher mucosal bicarbonate secretion, Paneth cell dysfunction, and intestinal inflammation, are currently being explored. The potential role of small intestinal microbiomes in Mg(2+) absorption has also been proposed. In this article, we reviewed the current knowledge on the mechanisms and regulatory factors of small intestinal Mg(2+) absorption. |
format | Online Article Text |
id | pubmed-9846944 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-98469442023-01-19 Current opinion on the regulation of small intestinal magnesium absorption Chamniansawat, Siriporn Suksridechacin, Nasisorn Thongon, Narongrit World J Gastroenterol Minireviews Magnesium (Mg(2+)) has an important role in numerous biological functions, and Mg(2+) deficiency is associated with several diseases. Therefore, adequate intestinal absorption of Mg(2+) is vital for health. The small intestine was previously thought to absorb digested Mg(2+) exclusively through an unregulated paracellular mechanism, which is responsible for approximately 90% of total Mg(2+) absorption. Recent studies, however, have revealed that the duodenum, jejunum, and ileum absorb Mg(2+) through both transcellular and paracellular routes. Several regulatory factors of small intestinal Mg(2+) uptake also have been explored, e.g., parathyroid hormone, fibroblast growth factor-23, apical acidity, proton pump inhibitor, and pH-sensing channel and receptors. The mechanistic factors underlying proton pump inhibitor suppression of small intestinal Mg(2+), such as magnesiotropic protein dysfunction, higher mucosal bicarbonate secretion, Paneth cell dysfunction, and intestinal inflammation, are currently being explored. The potential role of small intestinal microbiomes in Mg(2+) absorption has also been proposed. In this article, we reviewed the current knowledge on the mechanisms and regulatory factors of small intestinal Mg(2+) absorption. Baishideng Publishing Group Inc 2023-01-14 2023-01-14 /pmc/articles/PMC9846944/ /pubmed/36687126 http://dx.doi.org/10.3748/wjg.v29.i2.332 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Minireviews Chamniansawat, Siriporn Suksridechacin, Nasisorn Thongon, Narongrit Current opinion on the regulation of small intestinal magnesium absorption |
title | Current opinion on the regulation of small intestinal magnesium absorption |
title_full | Current opinion on the regulation of small intestinal magnesium absorption |
title_fullStr | Current opinion on the regulation of small intestinal magnesium absorption |
title_full_unstemmed | Current opinion on the regulation of small intestinal magnesium absorption |
title_short | Current opinion on the regulation of small intestinal magnesium absorption |
title_sort | current opinion on the regulation of small intestinal magnesium absorption |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846944/ https://www.ncbi.nlm.nih.gov/pubmed/36687126 http://dx.doi.org/10.3748/wjg.v29.i2.332 |
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