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Ochronotic arthropathy of bilateral hip joints: A case report

BACKGROUND: Ochronosis, also known as alkaptonuria, is a rare autosomal recessive self-metabolic disease arising from deficiency of homogentisate 1,2 dioxygenase enzyme. It affects several organs and muscoskeletal structures. We herein report a case of a patient who presented with severe hip arthrop...

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Autores principales: Yap San Min, Nicolas, Rafi, Urba, Wang, Juan, He, Bin, Fan, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846970/
https://www.ncbi.nlm.nih.gov/pubmed/36687193
http://dx.doi.org/10.12998/wjcc.v11.i1.210
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author Yap San Min, Nicolas
Rafi, Urba
Wang, Juan
He, Bin
Fan, Lei
author_facet Yap San Min, Nicolas
Rafi, Urba
Wang, Juan
He, Bin
Fan, Lei
author_sort Yap San Min, Nicolas
collection PubMed
description BACKGROUND: Ochronosis, also known as alkaptonuria, is a rare autosomal recessive self-metabolic disease arising from deficiency of homogentisate 1,2 dioxygenase enzyme. It affects several organs and muscoskeletal structures. We herein report a case of a patient who presented with severe hip arthropathy complicated with late stage ochronosis. CASE SUMMARY: A 56-year-old male patient was admitted in our department in 2019 with complaints of chronic low backache and left hip pain. After the required investigations were done, lumbar disc herniation and severe hip arthritis were the initial diagnosis. A total left hip arthroplasty was performed. Ochronotic osteoarthritis was only obtained post-surgery as confirmatory diagnosis. He was again admitted mid 2022 with the same complaints on the right hip. Subsequently, he underwent a total right hip arthroplasty. Post-operative recovery and follow-ups were deemed very satisfactory. CONCLUSION: Ochronosis is an unusual diagnosis for a patient who presents with typical hip arthritis. Thus, unless meticulous history taking and advanced laboratory tests, the diagnosis can easily be missed by surgeons.
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spelling pubmed-98469702023-01-19 Ochronotic arthropathy of bilateral hip joints: A case report Yap San Min, Nicolas Rafi, Urba Wang, Juan He, Bin Fan, Lei World J Clin Cases Case Report BACKGROUND: Ochronosis, also known as alkaptonuria, is a rare autosomal recessive self-metabolic disease arising from deficiency of homogentisate 1,2 dioxygenase enzyme. It affects several organs and muscoskeletal structures. We herein report a case of a patient who presented with severe hip arthropathy complicated with late stage ochronosis. CASE SUMMARY: A 56-year-old male patient was admitted in our department in 2019 with complaints of chronic low backache and left hip pain. After the required investigations were done, lumbar disc herniation and severe hip arthritis were the initial diagnosis. A total left hip arthroplasty was performed. Ochronotic osteoarthritis was only obtained post-surgery as confirmatory diagnosis. He was again admitted mid 2022 with the same complaints on the right hip. Subsequently, he underwent a total right hip arthroplasty. Post-operative recovery and follow-ups were deemed very satisfactory. CONCLUSION: Ochronosis is an unusual diagnosis for a patient who presents with typical hip arthritis. Thus, unless meticulous history taking and advanced laboratory tests, the diagnosis can easily be missed by surgeons. Baishideng Publishing Group Inc 2023-01-06 2023-01-06 /pmc/articles/PMC9846970/ /pubmed/36687193 http://dx.doi.org/10.12998/wjcc.v11.i1.210 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Case Report
Yap San Min, Nicolas
Rafi, Urba
Wang, Juan
He, Bin
Fan, Lei
Ochronotic arthropathy of bilateral hip joints: A case report
title Ochronotic arthropathy of bilateral hip joints: A case report
title_full Ochronotic arthropathy of bilateral hip joints: A case report
title_fullStr Ochronotic arthropathy of bilateral hip joints: A case report
title_full_unstemmed Ochronotic arthropathy of bilateral hip joints: A case report
title_short Ochronotic arthropathy of bilateral hip joints: A case report
title_sort ochronotic arthropathy of bilateral hip joints: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846970/
https://www.ncbi.nlm.nih.gov/pubmed/36687193
http://dx.doi.org/10.12998/wjcc.v11.i1.210
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