FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms

BACKGROUND: Astrocytes play a crucial, yet not fully elucidated role in the selective motor neuron pathology in amyotrophic lateral sclerosis (ALS). Among other responsibilities, astrocytes provide important neuronal homeostatic support, however this function is highly compromised in ALS. The establ...

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Detalles Bibliográficos
Autores principales: Stoklund Dittlau, Katarina, Terrie, Lisanne, Baatsen, Pieter, Kerstens, Axelle, De Swert, Lim, Janky, Rekin’s, Corthout, Nikky, Masrori, Pegah, Van Damme, Philip, Hyttel, Poul, Meyer, Morten, Thorrez, Lieven, Freude, Kristine, Van Den Bosch, Ludo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847053/
https://www.ncbi.nlm.nih.gov/pubmed/36653804
http://dx.doi.org/10.1186/s13024-022-00591-3

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