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A pH-responsive metal-organic framework for the co-delivery of HIF-2α siRNA and curcumin for enhanced therapy of osteoarthritis

The occurrence of osteoarthritis (OA) is highly correlated with the reduction of joint lubrication performance, in which persistent excessive inflammation and irreversible destruction of cartilage dominate the mechanism. The inadequate response to monotherapy methods, suboptimal efficacy caused by u...

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Detalles Bibliográficos
Autores principales:	Zhang, Zi-Jian, Hou, Ying-Ke, Chen, Ming-Wa, Yu, Xue-Zhao, Chen, Si-Yu, Yue, Ya-Ru, Guo, Xiong-Tian, Chen, Jin-Xiang, Zhou, Quan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847079/ https://www.ncbi.nlm.nih.gov/pubmed/36650517 http://dx.doi.org/10.1186/s12951-022-01758-2

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