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[(68)Ga]Ga-FAPI-04 PET MRI/CT in the evaluation of gastric carcinomas compared with [(18)F]-FDG PET MRI/CT: a meta-analysis
OBJECTIVES: To compare the detection rates of [(68)Ga]Ga-FAPI-04 PET MRI/CT vs. [(18)F]-FDG PET MRI/CT in gastric cancer. METHODS: An extensive librarian-led literature search of PubMed, Embase, Web of Science, the Cochrane Central Library, and ClinicalTrials.gov was performed. The primary outcomes...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847115/ https://www.ncbi.nlm.nih.gov/pubmed/36653862 http://dx.doi.org/10.1186/s40001-023-00997-9 |
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author | Wang, Yawen Luo, Wenhao Li, Ye |
author_facet | Wang, Yawen Luo, Wenhao Li, Ye |
author_sort | Wang, Yawen |
collection | PubMed |
description | OBJECTIVES: To compare the detection rates of [(68)Ga]Ga-FAPI-04 PET MRI/CT vs. [(18)F]-FDG PET MRI/CT in gastric cancer. METHODS: An extensive librarian-led literature search of PubMed, Embase, Web of Science, the Cochrane Central Library, and ClinicalTrials.gov was performed. The primary outcomes were sensitivity in patient-based evaluations, detection of lymph node metastases, and peritoneal involvement. RESULTS: Five studies, including 148 participants, were analyzed. [(68)Ga]Ga-FAPI-04 PET MRI/CT has a comparatively high sensitivity in patient-based evaluations compared with [(18)F]-FDG PET MRI/CT (risk difference = 0.16, 95% CI 0.09–0.22, P < 0.00001). The [(68)Ga]Ga-FAPI-04 PET MRI/CT group has a comparatively higher sensitivity in detecting lymph node metastases (RR = 0.15, 95% CI 0.01–0.29, P = 0.04), peritoneal involvement (RR = 0.55, 95% CI 0.38–0.72, P < 0.00001) in gastric cancer than [(18)F]-FDG PET MRI/CT group. CONCLUSIONS: This systematic review confirmed the advantage of [(68)Ga]Ga-FAPI-04 PET MRI/CT in gastric cancer. [(68)Ga]Ga-FAPI-04 PET MRI/CT was superior to [(18)F]-FDG PET MRI/CT in detecting the primary tumor, lymph node metastases, and peritoneal metastases. More studies are needed for the sensitivity and specificity of [(68)Ga]Ga-FAPI-04 PET MRI/CT in different pathological types of gastric cancer. |
format | Online Article Text |
id | pubmed-9847115 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-98471152023-01-19 [(68)Ga]Ga-FAPI-04 PET MRI/CT in the evaluation of gastric carcinomas compared with [(18)F]-FDG PET MRI/CT: a meta-analysis Wang, Yawen Luo, Wenhao Li, Ye Eur J Med Res Review OBJECTIVES: To compare the detection rates of [(68)Ga]Ga-FAPI-04 PET MRI/CT vs. [(18)F]-FDG PET MRI/CT in gastric cancer. METHODS: An extensive librarian-led literature search of PubMed, Embase, Web of Science, the Cochrane Central Library, and ClinicalTrials.gov was performed. The primary outcomes were sensitivity in patient-based evaluations, detection of lymph node metastases, and peritoneal involvement. RESULTS: Five studies, including 148 participants, were analyzed. [(68)Ga]Ga-FAPI-04 PET MRI/CT has a comparatively high sensitivity in patient-based evaluations compared with [(18)F]-FDG PET MRI/CT (risk difference = 0.16, 95% CI 0.09–0.22, P < 0.00001). The [(68)Ga]Ga-FAPI-04 PET MRI/CT group has a comparatively higher sensitivity in detecting lymph node metastases (RR = 0.15, 95% CI 0.01–0.29, P = 0.04), peritoneal involvement (RR = 0.55, 95% CI 0.38–0.72, P < 0.00001) in gastric cancer than [(18)F]-FDG PET MRI/CT group. CONCLUSIONS: This systematic review confirmed the advantage of [(68)Ga]Ga-FAPI-04 PET MRI/CT in gastric cancer. [(68)Ga]Ga-FAPI-04 PET MRI/CT was superior to [(18)F]-FDG PET MRI/CT in detecting the primary tumor, lymph node metastases, and peritoneal metastases. More studies are needed for the sensitivity and specificity of [(68)Ga]Ga-FAPI-04 PET MRI/CT in different pathological types of gastric cancer. BioMed Central 2023-01-18 /pmc/articles/PMC9847115/ /pubmed/36653862 http://dx.doi.org/10.1186/s40001-023-00997-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Wang, Yawen Luo, Wenhao Li, Ye [(68)Ga]Ga-FAPI-04 PET MRI/CT in the evaluation of gastric carcinomas compared with [(18)F]-FDG PET MRI/CT: a meta-analysis |
title | [(68)Ga]Ga-FAPI-04 PET MRI/CT in the evaluation of gastric carcinomas compared with [(18)F]-FDG PET MRI/CT: a meta-analysis |
title_full | [(68)Ga]Ga-FAPI-04 PET MRI/CT in the evaluation of gastric carcinomas compared with [(18)F]-FDG PET MRI/CT: a meta-analysis |
title_fullStr | [(68)Ga]Ga-FAPI-04 PET MRI/CT in the evaluation of gastric carcinomas compared with [(18)F]-FDG PET MRI/CT: a meta-analysis |
title_full_unstemmed | [(68)Ga]Ga-FAPI-04 PET MRI/CT in the evaluation of gastric carcinomas compared with [(18)F]-FDG PET MRI/CT: a meta-analysis |
title_short | [(68)Ga]Ga-FAPI-04 PET MRI/CT in the evaluation of gastric carcinomas compared with [(18)F]-FDG PET MRI/CT: a meta-analysis |
title_sort | [(68)ga]ga-fapi-04 pet mri/ct in the evaluation of gastric carcinomas compared with [(18)f]-fdg pet mri/ct: a meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847115/ https://www.ncbi.nlm.nih.gov/pubmed/36653862 http://dx.doi.org/10.1186/s40001-023-00997-9 |
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