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Highlights of Pharmacist Roles in Hematopoietic Cell Transplantation and Cellular Therapy
Patients with hematological malignancies receiving hematopoietic stem cell transplantation (HSCT) or chimeric antigen receptor (CAR) T-cell therapy are known to have complex pharmacotherapy. To ensure safe and effective care in preventing and managing drug-related problems, pharmacists trained in HS...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Asia-Pacific Blood and Marrow Transplantation Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847305/ https://www.ncbi.nlm.nih.gov/pubmed/36713470 http://dx.doi.org/10.31547/bct-2021-016 |
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author | Shi, Ho Ying Tharnpanich, Trai Yu, Bo |
author_facet | Shi, Ho Ying Tharnpanich, Trai Yu, Bo |
author_sort | Shi, Ho Ying |
collection | PubMed |
description | Patients with hematological malignancies receiving hematopoietic stem cell transplantation (HSCT) or chimeric antigen receptor (CAR) T-cell therapy are known to have complex pharmacotherapy. To ensure safe and effective care in preventing and managing drug-related problems, pharmacists trained in HSCT and CAR T-cell therapy fulfill various roles in providing care for these patients. With polypharmacy and complex medication regimens, drug interactions are one of the major aspects that pharmacists review regularly to ensure the efficacy of treatment while minimizing toxicity. Pharmacists anticipate various complex drug interactions, understanding the possible mechanisms of drug interactions, and manage these complex drug regimens in patients undergoing HSCT and CAR T-cell therapy. In addition, antimicrobial prophylaxis is also important supportive care for immunocompromised patients. Pharmacists are capable of evaluating the risk of opportunistic infections, anticipating the type of antimicrobial prophylaxis required, and setting a policy with a robust antimicrobial regime. This can promote consistency in patient care and improve patient outcomes in terms of morbidity and mortality associated with opportunistic infections. Lastly, pharmacists are equipped with a skillset to ensure a seamless transition of care, provide education for patients and healthcare providers, promote medication adherence, and contribute to research and quality improvement. |
format | Online Article Text |
id | pubmed-9847305 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Asia-Pacific Blood and Marrow Transplantation Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-98473052023-01-27 Highlights of Pharmacist Roles in Hematopoietic Cell Transplantation and Cellular Therapy Shi, Ho Ying Tharnpanich, Trai Yu, Bo Blood Cell Ther State of the Art Patients with hematological malignancies receiving hematopoietic stem cell transplantation (HSCT) or chimeric antigen receptor (CAR) T-cell therapy are known to have complex pharmacotherapy. To ensure safe and effective care in preventing and managing drug-related problems, pharmacists trained in HSCT and CAR T-cell therapy fulfill various roles in providing care for these patients. With polypharmacy and complex medication regimens, drug interactions are one of the major aspects that pharmacists review regularly to ensure the efficacy of treatment while minimizing toxicity. Pharmacists anticipate various complex drug interactions, understanding the possible mechanisms of drug interactions, and manage these complex drug regimens in patients undergoing HSCT and CAR T-cell therapy. In addition, antimicrobial prophylaxis is also important supportive care for immunocompromised patients. Pharmacists are capable of evaluating the risk of opportunistic infections, anticipating the type of antimicrobial prophylaxis required, and setting a policy with a robust antimicrobial regime. This can promote consistency in patient care and improve patient outcomes in terms of morbidity and mortality associated with opportunistic infections. Lastly, pharmacists are equipped with a skillset to ensure a seamless transition of care, provide education for patients and healthcare providers, promote medication adherence, and contribute to research and quality improvement. Asia-Pacific Blood and Marrow Transplantation Group 2021-10-14 /pmc/articles/PMC9847305/ /pubmed/36713470 http://dx.doi.org/10.31547/bct-2021-016 Text en Copyright Ⓒ2021 Asia-Pacific Blood and Marrow Transplantation Group (APBMT). https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under CC BY-NC license (https://creativecommons.org/licenses/by-nc/4.0/). |
spellingShingle | State of the Art Shi, Ho Ying Tharnpanich, Trai Yu, Bo Highlights of Pharmacist Roles in Hematopoietic Cell Transplantation and Cellular Therapy |
title | Highlights of Pharmacist Roles in Hematopoietic Cell Transplantation and Cellular Therapy |
title_full | Highlights of Pharmacist Roles in Hematopoietic Cell Transplantation and Cellular Therapy |
title_fullStr | Highlights of Pharmacist Roles in Hematopoietic Cell Transplantation and Cellular Therapy |
title_full_unstemmed | Highlights of Pharmacist Roles in Hematopoietic Cell Transplantation and Cellular Therapy |
title_short | Highlights of Pharmacist Roles in Hematopoietic Cell Transplantation and Cellular Therapy |
title_sort | highlights of pharmacist roles in hematopoietic cell transplantation and cellular therapy |
topic | State of the Art |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847305/ https://www.ncbi.nlm.nih.gov/pubmed/36713470 http://dx.doi.org/10.31547/bct-2021-016 |
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