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Gender Differences in the Prevalence of Parkinson's Disease
BACKGROUND: Parkinson's disease (PD) affects males more than females. The reasons for the gender differences in PD prevalence remain unclear. OBJECTIVE: The objective of this systematic review and meta‐analysis was to update the overall male/female prevalence ratios (OPR). METHODS: We updated p...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847309/ https://www.ncbi.nlm.nih.gov/pubmed/36699001 http://dx.doi.org/10.1002/mdc3.13584 |
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author | Zirra, Alexandra Rao, Shilpa C. Bestwick, Jonathan Rajalingam, Rajasumi Marras, Connie Blauwendraat, Cornelis Mata, Ignacio F. Noyce, Alastair J. |
author_facet | Zirra, Alexandra Rao, Shilpa C. Bestwick, Jonathan Rajalingam, Rajasumi Marras, Connie Blauwendraat, Cornelis Mata, Ignacio F. Noyce, Alastair J. |
author_sort | Zirra, Alexandra |
collection | PubMed |
description | BACKGROUND: Parkinson's disease (PD) affects males more than females. The reasons for the gender differences in PD prevalence remain unclear. OBJECTIVE: The objective of this systematic review and meta‐analysis was to update the overall male/female prevalence ratios (OPR). METHODS: We updated previous work by searching MEDLINE, SCOPUS, and OVID for articles reporting PD prevalence for both genders between 2011 and 2021. We calculated OPRs and investigated heterogeneity in effect estimates. RESULTS: We included 19 new articles and 13 articles from a previously published meta‐analysis. The OPR was 1.18, 95% CI, [1.03, 1.36]. The OPR was lowest in Asia and appeared to be decreasing over time. Study design, national wealth, and participant age did not explain OPR heterogeneity. CONCLUSION: Gender differences in PD prevalence may not be as stark as previously thought. Studies are needed to understand the role of other determinants of gender differences in PD prevalence. |
format | Online Article Text |
id | pubmed-9847309 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98473092023-01-24 Gender Differences in the Prevalence of Parkinson's Disease Zirra, Alexandra Rao, Shilpa C. Bestwick, Jonathan Rajalingam, Rajasumi Marras, Connie Blauwendraat, Cornelis Mata, Ignacio F. Noyce, Alastair J. Mov Disord Clin Pract Brief Reports BACKGROUND: Parkinson's disease (PD) affects males more than females. The reasons for the gender differences in PD prevalence remain unclear. OBJECTIVE: The objective of this systematic review and meta‐analysis was to update the overall male/female prevalence ratios (OPR). METHODS: We updated previous work by searching MEDLINE, SCOPUS, and OVID for articles reporting PD prevalence for both genders between 2011 and 2021. We calculated OPRs and investigated heterogeneity in effect estimates. RESULTS: We included 19 new articles and 13 articles from a previously published meta‐analysis. The OPR was 1.18, 95% CI, [1.03, 1.36]. The OPR was lowest in Asia and appeared to be decreasing over time. Study design, national wealth, and participant age did not explain OPR heterogeneity. CONCLUSION: Gender differences in PD prevalence may not be as stark as previously thought. Studies are needed to understand the role of other determinants of gender differences in PD prevalence. John Wiley & Sons, Inc. 2022-11-14 /pmc/articles/PMC9847309/ /pubmed/36699001 http://dx.doi.org/10.1002/mdc3.13584 Text en © 2022 The Authors. Movement Disorders Clinical Practice published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Reports Zirra, Alexandra Rao, Shilpa C. Bestwick, Jonathan Rajalingam, Rajasumi Marras, Connie Blauwendraat, Cornelis Mata, Ignacio F. Noyce, Alastair J. Gender Differences in the Prevalence of Parkinson's Disease |
title | Gender Differences in the Prevalence of Parkinson's Disease |
title_full | Gender Differences in the Prevalence of Parkinson's Disease |
title_fullStr | Gender Differences in the Prevalence of Parkinson's Disease |
title_full_unstemmed | Gender Differences in the Prevalence of Parkinson's Disease |
title_short | Gender Differences in the Prevalence of Parkinson's Disease |
title_sort | gender differences in the prevalence of parkinson's disease |
topic | Brief Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847309/ https://www.ncbi.nlm.nih.gov/pubmed/36699001 http://dx.doi.org/10.1002/mdc3.13584 |
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