Cargando…

Gender Differences in the Prevalence of Parkinson's Disease

BACKGROUND: Parkinson's disease (PD) affects males more than females. The reasons for the gender differences in PD prevalence remain unclear. OBJECTIVE: The objective of this systematic review and meta‐analysis was to update the overall male/female prevalence ratios (OPR). METHODS: We updated p...

Descripción completa

Detalles Bibliográficos
Autores principales: Zirra, Alexandra, Rao, Shilpa C., Bestwick, Jonathan, Rajalingam, Rajasumi, Marras, Connie, Blauwendraat, Cornelis, Mata, Ignacio F., Noyce, Alastair J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847309/
https://www.ncbi.nlm.nih.gov/pubmed/36699001
http://dx.doi.org/10.1002/mdc3.13584
_version_ 1784871426004615168
author Zirra, Alexandra
Rao, Shilpa C.
Bestwick, Jonathan
Rajalingam, Rajasumi
Marras, Connie
Blauwendraat, Cornelis
Mata, Ignacio F.
Noyce, Alastair J.
author_facet Zirra, Alexandra
Rao, Shilpa C.
Bestwick, Jonathan
Rajalingam, Rajasumi
Marras, Connie
Blauwendraat, Cornelis
Mata, Ignacio F.
Noyce, Alastair J.
author_sort Zirra, Alexandra
collection PubMed
description BACKGROUND: Parkinson's disease (PD) affects males more than females. The reasons for the gender differences in PD prevalence remain unclear. OBJECTIVE: The objective of this systematic review and meta‐analysis was to update the overall male/female prevalence ratios (OPR). METHODS: We updated previous work by searching MEDLINE, SCOPUS, and OVID for articles reporting PD prevalence for both genders between 2011 and 2021. We calculated OPRs and investigated heterogeneity in effect estimates. RESULTS: We included 19 new articles and 13 articles from a previously published meta‐analysis. The OPR was 1.18, 95% CI, [1.03, 1.36]. The OPR was lowest in Asia and appeared to be decreasing over time. Study design, national wealth, and participant age did not explain OPR heterogeneity. CONCLUSION: Gender differences in PD prevalence may not be as stark as previously thought. Studies are needed to understand the role of other determinants of gender differences in PD prevalence.
format Online
Article
Text
id pubmed-9847309
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley & Sons, Inc.
record_format MEDLINE/PubMed
spelling pubmed-98473092023-01-24 Gender Differences in the Prevalence of Parkinson's Disease Zirra, Alexandra Rao, Shilpa C. Bestwick, Jonathan Rajalingam, Rajasumi Marras, Connie Blauwendraat, Cornelis Mata, Ignacio F. Noyce, Alastair J. Mov Disord Clin Pract Brief Reports BACKGROUND: Parkinson's disease (PD) affects males more than females. The reasons for the gender differences in PD prevalence remain unclear. OBJECTIVE: The objective of this systematic review and meta‐analysis was to update the overall male/female prevalence ratios (OPR). METHODS: We updated previous work by searching MEDLINE, SCOPUS, and OVID for articles reporting PD prevalence for both genders between 2011 and 2021. We calculated OPRs and investigated heterogeneity in effect estimates. RESULTS: We included 19 new articles and 13 articles from a previously published meta‐analysis. The OPR was 1.18, 95% CI, [1.03, 1.36]. The OPR was lowest in Asia and appeared to be decreasing over time. Study design, national wealth, and participant age did not explain OPR heterogeneity. CONCLUSION: Gender differences in PD prevalence may not be as stark as previously thought. Studies are needed to understand the role of other determinants of gender differences in PD prevalence. John Wiley & Sons, Inc. 2022-11-14 /pmc/articles/PMC9847309/ /pubmed/36699001 http://dx.doi.org/10.1002/mdc3.13584 Text en © 2022 The Authors. Movement Disorders Clinical Practice published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Reports
Zirra, Alexandra
Rao, Shilpa C.
Bestwick, Jonathan
Rajalingam, Rajasumi
Marras, Connie
Blauwendraat, Cornelis
Mata, Ignacio F.
Noyce, Alastair J.
Gender Differences in the Prevalence of Parkinson's Disease
title Gender Differences in the Prevalence of Parkinson's Disease
title_full Gender Differences in the Prevalence of Parkinson's Disease
title_fullStr Gender Differences in the Prevalence of Parkinson's Disease
title_full_unstemmed Gender Differences in the Prevalence of Parkinson's Disease
title_short Gender Differences in the Prevalence of Parkinson's Disease
title_sort gender differences in the prevalence of parkinson's disease
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847309/
https://www.ncbi.nlm.nih.gov/pubmed/36699001
http://dx.doi.org/10.1002/mdc3.13584
work_keys_str_mv AT zirraalexandra genderdifferencesintheprevalenceofparkinsonsdisease
AT raoshilpac genderdifferencesintheprevalenceofparkinsonsdisease
AT bestwickjonathan genderdifferencesintheprevalenceofparkinsonsdisease
AT rajalingamrajasumi genderdifferencesintheprevalenceofparkinsonsdisease
AT marrasconnie genderdifferencesintheprevalenceofparkinsonsdisease
AT blauwendraatcornelis genderdifferencesintheprevalenceofparkinsonsdisease
AT mataignaciof genderdifferencesintheprevalenceofparkinsonsdisease
AT noycealastairj genderdifferencesintheprevalenceofparkinsonsdisease