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A novel humanized Chi3l1 blocking antibody attenuates acetaminophen-induced liver injury in mice

Acetaminophen (APAP) overdose is a leading cause of acute liver injury in the USA. The chitinase 3-like-1 (Chi3l1) protein contributes to APAP-induced liver injury (AILI) by promoting hepatic platelet recruitment. Here, we report the development of a Chi3l1-targeting antibody as a potential therapy...

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Detalles Bibliográficos
Autores principales:	Li, Leike, Wen, Yankai, Wrapp, Daniel, Jeong, Jongmin, Zhao, Peng, Xiong, Wei, Atkins, Constance Lynn, Shan, Zhao, Hui, Deng, McLellan, Jason S, Zhang, Ningyan, Ju, Cynthia, An, Zhiqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847341/ https://www.ncbi.nlm.nih.gov/pubmed/36683763 http://dx.doi.org/10.1093/abt/tbac027

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