Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2

The 3C-like protease (3CL(pro)) is essential for the replication and transcription of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), making it a promising target for the treatment of corona virus disease 2019 (COVID-19). In this study, a series of 2,3,5-substituted [1,2,4]-thiadiazole...

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Detalles Bibliográficos
Autores principales: Ren, Pengxuan, Yu, Changyue, Zhang, Ruxue, Nie, Tianqing, Hu, Qiaoyu, Li, Hui, Zhang, Xianglei, Zhang, Xueyuan, Li, Shiwei, Liu, Lu, Dai, Wenhao, Li, Jian, Xu, Yechun, Su, Haixia, Zhang, Leike, Liu, Hong, Bai, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847367/
https://www.ncbi.nlm.nih.gov/pubmed/36702052
http://dx.doi.org/10.1016/j.ejmech.2023.115129

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